Paraxanthine provides greater improvement in cognitive function than caffeine after performing a 10-km run

Autor: Choongsung Yoo, Dante Xing, Drew E. Gonzalez, Victoria Jenkins, Kay Nottingham, Broderick Dickerson, Megan Leonard, Joungbo Ko, Megan H. Lewis, Mark Faries, Wesley Kephart, Martin Purpura, Ralf Jäger, Shawn D. Wells, Kylin Liao, Ryan Sowinski, Christopher J. Rasmussen, Richard B. Kreider

Publikováno v: Journal of the International Society of Sports Nutrition, Vol 21, Iss 1 (2024)

ABSTRACTRationale Intense exercise promotes fatigue and can impair cognitive function, particularly toward the end of competition when decision-making is often critical for success. For this reason, athletes often ingest caffeinated energy drinks pri

Externí odkaz: https://doaj.org/article/2bcae71d7049400a9a67651d8aab64ca

A conceptual framework for landscape-based environmental risk assessment (ERA) of pesticides

Autor: Jose V. Tarazona, Mercedes de Alba-Gonzalez, Carole Bedos, Pierre Benoit, Colette Bertrand, Olivier Crouzet, Cécile Dagès, Jean-Lou CM Dorne, Ana Fernandez-Agudo, Andreas Focks, Maria del Carmen Gonzalez-Caballero, Alexandra Kroll, Matthias Liess, Susana Loureiro, Manuel E. Ortiz-Santaliestra, Jes J. Rasmussen, Raphaël Royauté, Maj Rundlöf, Ralf B. Schäfer, Stephen Short, Ayesha Siddique, José Paulo Sousa, Dave Spurgeon, Pierre-François Staub, Chris J. Topping, Marc Voltz, Johan Axelman, Annette Aldrich, Sabine Duquesne, Vanessa Mazerolles, Yann Devos

Publikováno v: Environment International, Vol 191, Iss , Pp 108999- (2024)

While pesticide use is subject to strict regulatory oversight worldwide, it remains a main concern for environmental protection, including biodiversity conservation. This is partly due to the current regulatory approach that relies on separate assess

Externí odkaz: https://doaj.org/article/764f87173c94442eaf833e411f4595cd

The DNA repair enzyme, aprataxin, plays a role in innate immune signaling

Autor: Helena B. Madsen, Louise I. Pease, Rebekah-Louise Scanlan, Mansour Akbari, Lene J. Rasmussen, Daryl P. Shanley, Vilhelm A. Bohr

Publikováno v: Frontiers in Aging Neuroscience, Vol 15 (2023)

Ataxia with oculomotor apraxia type 1 (AOA1) is a progressive neurodegenerative disorder characterized by a gradual loss of coordination of hand movements, speech, and eye movements. AOA1 is caused by an inactivation mutation in the APTX gene. APTX r

Externí odkaz: https://doaj.org/article/a6596f6c18f54f9cb2dd3ab9d8bb0b99

Secretory leukocyte protease inhibitor and risk of heart failure in the Multi-Ethnic Study of Atherosclerosis

Autor: Konrad Teodor Sawicki, Drew R. Nannini, Suzette J. Bielinski, Nicholas B. Larson, Donald M. Lloyd-Jones, Bruce Psaty, Kent D. Taylor, Sanjiv J. Shah, Laura J. Rasmussen-Torvik, John T. Wilkins, Elizabeth M. McNally, Ravi B. Patel

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)

Abstract Circulating protease inhibitors are important regulators of inflammation that are implicated in the pathophysiology of heart failure (HF). Secretory leukocyte protease inhibitor (SLPI) is a serine protease inhibitor which protects pulmonary

Externí odkaz: https://doaj.org/article/aa784adc542245dba4ab31c8f58a617e

Colorectal cancer incidences in Lynch syndrome: a comparison of results from the prospective lynch syndrome database and the international mismatch repair consortium

Autor: Pål Møller, Toni Seppälä, James G. Dowty, Saskia Haupt, Mev Dominguez-Valentin, Lone Sunde, Inge Bernstein, Christoph Engel, Stefan Aretz, Maartje Nielsen, Gabriel Capella, Dafydd Gareth Evans, John Burn, Elke Holinski-Feder, Lucio Bertario, Bernardo Bonanni, Annika Lindblom, Zohar Levi, Finlay Macrae, Ingrid Winship, John-Paul Plazzer, Rolf Sijmons, Luigi Laghi, Adriana Della Valle, Karl Heinimann, Elizabeth Half, Francisco Lopez-Koestner, Karin Alvarez-Valenzuela, Rodney J. Scott, Lior Katz, Ido Laish, Elez Vainer, Carlos Alberto Vaccaro, Dirce Maria Carraro, Nathan Gluck, Naim Abu-Freha, Aine Stakelum, Rory Kennelly, Des Winter, Benedito Mauro Rossi, Marc Greenblatt, Mabel Bohorquez, Harsh Sheth, Maria Grazia Tibiletti, Leonardo S. Lino-Silva, Karoline Horisberger, Carmen Portenkirchner, Ivana Nascimento, Norma Teresa Rossi, Leandro Apolinário da Silva, Huw Thomas, Attila Zaránd, Jukka-Pekka Mecklin, Kirsi Pylvänäinen, Laura Renkonen-Sinisalo, Anna Lepisto, Päivi Peltomäki, Christina Therkildsen, Lars Joachim Lindberg, Ole Thorlacius-Ussing, Magnus von Knebel Doeberitz, Markus Loeffler, Nils Rahner, Verena Steinke-Lange, Wolff Schmiegel, Deepak Vangala, Claudia Perne, Robert Hüneburg, Aída Falcón de Vargas, Andrew Latchford, Anne-Marie Gerdes, Ann-Sofie Backman, Carmen Guillén-Ponce, Carrie Snyder, Charlotte K. Lautrup, David Amor, Edenir Palmero, Elena Stoffel, Floor Duijkers, Michael J. Hall, Heather Hampel, Heinric Williams, Henrik Okkels, Jan Lubiński, Jeanette Reece, Joanne Ngeow, Jose G. Guillem, Julie Arnold, Karin Wadt, Kevin Monahan, Leigha Senter, Lene J. Rasmussen, Liselotte P. van Hest, Luigi Ricciardiello, Maija R. J. Kohonen-Corish, Marjolijn J. L. Ligtenberg, Melissa Southey, Melyssa Aronson, Mohd N. Zahary, N. Jewel Samadder, Nicola Poplawski, Nicoline Hoogerbrugge, Patrick J. Morrison, Paul James, Grant Lee, Rakefet Chen-Shtoyerman, Ravindran Ankathil, Rish Pai, Robyn Ward, Susan Parry, Tadeusz Dębniak, Thomas John, Thomas van Overeem Hansen, Trinidad Caldés, Tatsuro Yamaguchi, Verónica Barca-Tierno, Pilar Garre, Giulia Martina Cavestro, Jürgen Weitz, Silke Redler, Reinhard Büttner, Vincent Heuveline, John L. Hopper, Aung Ko Win, Noralane Lindor, Steven Gallinger, Loïc Le Marchand, Polly A. Newcomb, Jane Figueiredo, Daniel D. Buchanan, Stephen N. Thibodeau, Sanne W. ten Broeke, Eivind Hovig, Sigve Nakken, Marta Pineda, Nuria Dueñas, Joan Brunet, Kate Green, Fiona Lalloo, Katie Newton, Emma J. Crosbie, Miriam Mints, Douglas Tjandra, Florencia Neffa, Patricia Esperon, Revital Kariv, Guy Rosner, Walter Hernán Pavicic, Pablo Kalfayan, Giovana Tardin Torrezan, Thiago Bassaneze, Claudia Martin, Gabriela Moslein, Aysel Ahadova, Matthias Kloor, Julian R. Sampson, Mark A. Jenkins, The European Hereditary Tumour Group (EHTG) and the International Mismatch Repair Consortium (IMRC)

Publikováno v: Hereditary Cancer in Clinical Practice, Vol 20, Iss 1, Pp 1-11 (2022)

Abstract Objective To compare colorectal cancer (CRC) incidences in carriers of pathogenic variants of the MMR genes in the PLSD and IMRC cohorts, of which only the former included mandatory colonoscopy surveillance for all participants. Methods CRC

Externí odkaz: https://doaj.org/article/b931c1477d4f40ef8fbc4e978abfdf69