Zobrazeno 1 - 10 of 72 pro vyhledávání: '"P J Pentikäinen"'
1
Main results of the losartan versus amlodipine (LOA) study on drug tolerability and psychological general well-being
Autor: Lars H Lindholm, Björn Dahlöf, Jan Östergren, P. J. Pentikäinen, Shane L. Carney
Publikováno v: Journal of Hypertension. 15:1327-1335
Objective To compare two losartan regimens (with and without hydrochlorothiazide) and amlodipine in treating mild-to-moderate hypertension regarding their blood-pressure-lowering effect, drug tolerability and quality of life. Design A 12-week, random
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dfd0cab207690a4f73811f4245b206fd
https://doi.org/10.1097/00004872-199715110-00018
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2
Comparative Pharmacokinetics of Lovastatin, Simvastatin and Pravastatin in Humans
Autor: P. J. Pentikäinen, Michael S. Schwartz, J. Douglas Rogers, Françoise. Brunner-Ferber, Raju D. Amin, Markku Saraheimo, Jules I. Schwartz
Publikováno v: The Journal of Clinical Pharmacology. 32:136-140
Twelve healthy male volunteers received single market-image 40-mg oral doses of lovastatin and simvastatin (both lactone prodrugs), or pravastatin (a beta-hydroxyacid) at 1 week intervals in a three-way crossover study to quantify HMG-CoA reductase i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0509cc7278adc6772fd7774673bb9369
https://doi.org/10.1002/j.1552-4604.1992.tb03818.x
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3
Laboratory tests as predictors of the antihypertensive effects of amlodipine, bisoprolol, hydrochlorothiazide and losartan in men: results from the randomized, double-blind, crossover GENRES Study
Autor: Timo Suonsyrjä, Reijo S. Tilvis, Timo P. Hiltunen, Timo E. Strandberg, Ilkka Tikkanen, Helena E. Miettinen, Tuula Hannila-Handelberg, P. J. Pentikäinen, Kristian J Paavonen, Kimmo Kontula, Kati Donner
Publikováno v: Journal of hypertension. 26(6)
Objective Individual blood pressure responses to antihypertensive therapy are difficult to predict. To improve optimization of antihypertensive therapy, we analyzed correlations of relevant laboratory tests with blood pressure responses to four antih
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1de4d58b81b138381d601dc6b712880
https://pubmed.ncbi.nlm.nih.gov/18475165
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4
Predictors of antihypertensive drug responses: initial data from a placebo-controlled, randomized, cross-over study with four antihypertensive drugs (The GENRES Study)
Autor: Timo Suonsyrjä, Timo P. Hiltunen, Helena E. Miettinen, Kimmo Kontula, Reijo S. Tilvis, Juha Virolainen, Timo E. Strandberg, Kristian J Paavonen, Ilkka Tikkanen, Tuula Hannila-Handelberg, P. J. Pentikäinen
Publikováno v: American journal of hypertension. 20(3)
Background Only a minority of hypertensive individuals is adequately controlled for their hypertension, partially because reliable predictors for efficient antihypertensive drug therapy are lacking. Methods In a prospective, randomized, double-blind,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::468d0638c876d24f4d1bf4d36889019f
https://pubmed.ncbi.nlm.nih.gov/30265281
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7
Main results of the losartan versus amlodipine (LOA) study on drug tolerability and psychological general well-being. LOA Study Group
Autor: B, Dahlöf, L H, Lindholm, S, Carney, P J, Pentikäinen, J, Ostergren
Publikováno v: Journal of hypertension. 15(11)
To compare two losartan regimens (with and without hydrochlorothiazide) and amlodipine in treating mild-to-moderate hypertension regarding their blood-pressure-lowering effect, drug tolerability and quality of life.A 12-week, randomized, double-blind
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::66633116b9d9e7f1a2af7b768713bbdf
https://pubmed.ncbi.nlm.nih.gov/9383183
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8
Inhibition of soluble catechol-O-methyltransferase and single-dose pharmacokinetics after oral and intravenous administration of entacapone
Autor: M Karlsson, P. J. Pentikäinen, L. Seppälä, H Rita, T Wikberg, Eija Schultz, A. Gordin, T. Keränen, K Korpela
Publikováno v: European Journal of Clinical Pharmacology. 46
The inhibition of soluble catechol-O-methyl-transferase (S-COMT) in red blood cells (RBCs) by entacapone, and the pharmacokinetics of entacapone after single oral (5-800 mg) and i.v. (25 mg) doses have been examined in an open study in 12 healthy you
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ca916dbf083c6152873d92a8cf0fbe7
https://doi.org/10.1007/bf00199880
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9
The effect of catechol-O-methyl transferase inhibition by entacapone on the pharmacokinetics and metabolism of levodopa in healthy volunteers
Autor: P. J. Pentikäinen, L. Seppälä, V P Harjola, H Rita, T Wikberg, T. Keränen, K Korpela, A. Gordin, M Karlsson
Publikováno v: Clinical neuropharmacology. 16(2)
We studied the effect of inhibiting the enzyme catechol-O-methyltransferase (COMT) by a novel COMT inhibitor, entacapone, on the pharmacokinetics and metabolism of levodopa in 12 healthy male volunteers. Single increasing oral doses of entacapone (50
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bca4077d356d8bc8fd7b0a67c1a7dcc7
https://pubmed.ncbi.nlm.nih.gov/8477410
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