Zobrazeno 1 - 10
of 402
pro vyhledávání: '"P J Pagano"'
Autor:
Christopher M. Dustin, Sruti S. Shiva, Alberto Vazquez, Anum Saeed, Tharick Pascoal, Eugenia Cifuentes-Pagano, Patrick J. Pagano
Publikováno v:
Redox Biology, Vol 78, Iss , Pp 103433- (2024)
Alzheimer's Disease (AD), and related dementias, represent a growing concern for the worldwide population given the increased numbers of people of advanced age. Marked by significant degradation of neurological tissues and critical processes, in addi
Externí odkaz:
https://doaj.org/article/22148d7ff69948fbba041522342a4993
Publikováno v:
Biology, Vol 13, Iss 6, p 434 (2024)
The growing obesity epidemic necessitates increased research on adipocyte and adipose tissue function and disease mechanisms that progress obesity. Historically, adipocytes were viewed simply as storage for excess energy. However, recent studies have
Externí odkaz:
https://doaj.org/article/40fface4c3954b57bd8184d2c652c9ab
Publikováno v:
Eletrônica de Potência, Vol 28, Iss 4 (2023)
As is well known in practice, conventional transformerless inverters may suffer the risk of high-frequency leakage currents between the photovoltaic (PV) array or battery energy storage systems (BESS) and the ground due to the stray capacitances. Thi
Externí odkaz:
https://doaj.org/article/43b4c177bee04ecba899740271f15cbe
Autor:
Matthew T. Keeney, Eric K. Hoffman, Kyle Farmer, Christopher R. Bodle, Marco Fazzari, Alevtina Zharikov, Sandra L. Castro, Xiaoping Hu, Amanda Mortimer, Julia K. Kofler, Eugenia Cifuentes-Pagano, Patrick J. Pagano, Edward A. Burton, Teresa G. Hastings, J. Timothy Greenamyre, Roberto Di Maio
Publikováno v:
Neurobiology of Disease, Vol 170, Iss , Pp 105754- (2022)
Mitochondrial dysfunction and oxidative stress are strongly implicated in Parkinson's disease (PD) pathogenesis and there is evidence that mitochondrially-generated superoxide can activate NADPH oxidase 2 (NOX2). Although NOX2 has been examined in th
Externí odkaz:
https://doaj.org/article/95c583e7c1c84f7fafa51c450059efc9
Autor:
Lingyu Xu, Joseph J. Pagano, Mark J. Haykowksy, Justin A. Ezekowitz, Gavin Y. Oudit, Yoko Mikami, Andrew Howarth, James A. White, Jason R. B. Dyck, Todd Anderson, D. Ian Paterson, Richard B. Thompson, for the AB HEART Investigators
Publikováno v:
Journal of Cardiovascular Magnetic Resonance, Vol 22, Iss 1, Pp 1-16 (2020)
Abstract Background Global longitudinal strain (GLS), most commonly measured at the endocardium, has been shown to be superior to left ventricular (LV) ejection fraction (LVEF) for the identification of systolic dysfunction and prediction of outcomes
Externí odkaz:
https://doaj.org/article/612b80b2bf574b15aa4b98f715a3d8d1
Autor:
Shuai Yuan, Scott A. Hahn, Megan P. Miller, Subramaniam Sanker, Michael J. Calderon, Mara Sullivan, Atinuke M. Dosunmu-Ogunbi, Marco Fazzari, Yao Li, Michael Reynolds, Katherine C. Wood, Claudette M. St Croix, Donna Stolz, Eugenia Cifuentes-Pagano, Placido Navas, Sruti Shiva, Francisco J. Schopfer, Patrick J. Pagano, Adam C. Straub
Publikováno v:
Redox Biology, Vol 47, Iss , Pp 102166- (2021)
NADPH oxidase 4 (NOX4) regulates endothelial inflammation by producing hydrogen peroxide (H2O2) and to a lesser extent O2•-. The ratio of NOX4-derived H2O2 and O2•- can be altered by coenzyme Q (CoQ) mimics. Therefore, we hypothesize that cytochr
Externí odkaz:
https://doaj.org/article/8dc1b93959bb456aae238a06ad89c79a
Publikováno v:
Antioxidants, Vol 12, Iss 1, p 70 (2022)
Since their discovery in the vasculature, different NADPH oxidase (NOX) isoforms have been associated with numerous complex vascular processes such as endothelial dysfunction, vascular inflammation, arterial remodeling, and dyslipidemia. In turn, the
Externí odkaz:
https://doaj.org/article/8e5e0f73c4be4990adf8cf9a138bc2df
Autor:
Evan R. DeVallance, Christopher M. Dustin, Daniel Simoes de Jesus, Imad Al Ghouleh, John C. Sembrat, Eugenia Cifuentes-Pagano, Patrick J. Pagano
Publikováno v:
Antioxidants, Vol 12, Iss 1, p 71 (2022)
Pulmonary arterial hypertension (PAH) is a rare yet devastating and incurable disease with few treatment options. The underlying mechanisms of PAH appear to involve substantial cellular proliferation and vascular remodeling, causing right ventricular
Externí odkaz:
https://doaj.org/article/635c07f3c54844fa969104d819b7bff9
Autor:
Richard B. Thompson, Kelvin Chow, Joseph J. Pagano, Viktor Sekowski, Evangelos D. Michelakis, Wayne Tymchak, Mark J. Haykowsky, Justin A. Ezekowitz, Gavin Y. Oudit, Jason R. B. Dyck, Padma Kaul, Anamaria Savu, D. Ian Paterson
Publikováno v:
Journal of Cardiovascular Magnetic Resonance, Vol 21, Iss 1, Pp 1-11 (2019)
Abstract Background Pulmonary edema is a cardinal feature of heart failure but no quantitative tests are available in clinical practice. The goals of this study were to develop a simple cardiovascular magnetic resonance (CMR) approach for lung water
Externí odkaz:
https://doaj.org/article/4e483f14b8c0421b8b502ba55ced1f90
Autor:
Charlotte de Lange, Marjolein J. E. Reichert, Joseph J. Pagano, Mike Seed, Shi-Joon Yoo, Craig S. Broberg, Christopher Z. Lam, Lars Grosse-Wortmann
Publikováno v:
Journal of Cardiovascular Magnetic Resonance, Vol 21, Iss 1, Pp 1-10 (2019)
Abstract Background Patients with single ventricle physiology are at increased risk for developing liver fibrosis. Its extent and prevalence in children with bidirectional cavopulmonary connection (BCPC) and Fontan circulation are unclear. Extracellu
Externí odkaz:
https://doaj.org/article/22946dbf11a846859339bd5670243740