Zobrazeno 1 - 7
of 7
pro vyhledávání: '"P J Lennox Holt"'
Autor:
D. Black, P J Lennox Holt, Barbara Tomenson, Elaine M Hay, Francis Creed, A. Huddy, Robert M. Bernstein, P. Mbaya
Publikováno v:
Annals of the Rheumatic Diseases. 53:298-303
OBJECTIVES--To investigate change in psychiatric disorder and change in cognitive function in patients with systemic lupus erythematosus (SLE) assessed on two occasions two years apart. METHODS--A prospective cohort study of 49 patients with SLE usin
Publikováno v:
British journal of rheumatology. 29(4)
Antibodies to denatured type II collagen were detected in the sera of a group of patients with rheumatoid arthritis by ELISA and by immunoblotting. The antibodies were further examined by immunoblotting against cyanogen-bromide derived peptides of ty
Publikováno v:
Annals of the Rheumatic Diseases. 42:331-337
The relationship between cell mediated immunity to collagen and arthritis was studied with lymphocytes from arthritic and nonarthritic rats after immunisation with native bovine type II collagen. With the in-vivo radiometric ear assay arthritic rats
Publikováno v:
Journal of Immunological Methods. 27:31-41
A solid-phase radioimmunoassay has been developed using polystyrene tubes for the detection of class-specific antibodies to collagen. The optimal conditions for the adsorption of collagen onto the tubes, followed by incubation with the antisera and f
Autor:
Stephen A. Firth, Roy B. Clague, Mary J. Shaw, Trevor M. Twose, P. J. Lennox Holt, Keith Morgan
Publikováno v:
Arthritis & Rheumatism. 24:1356-1362
Antibodies to native bovine type II collagen may be important in initiating arthritis in rats immunized with this antigen. The cross-reactivity of these antibodies with native rat type II collagen was higher in rats that developed arthritis than in t
Autor:
Jacqueline B. Weiss, H.B. Evans, Kevin Morgan, M N Smith, P J Lennox Holt, Shirley Ayad, Stephen A. Firth
Publikováno v:
Annals of the Rheumatic Diseases. 42:680-683
Native 1 alpha 2 alpha 3 alpha collagen (500 micrograms per rat) was both immunogenic and arthritogenic in Alderley Park rats (46% developed arthritis) but only immunogenic in Sprague-Dawley rats. Conversely, native type II collagen (500 micrograms p
Publikováno v:
Arthritis & Rheumatism. 32:139-145
Antibodies to native and denatured collagens (types I, II, IX, and XI) were measured in sequential serum samples collected over 1.5-8.7 years (median 4.3) from 15 patients with rheumatoid arthritis. Eleven patients were seropositive and 4 were serone