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Akademický článek

Thrombolysis Outcomes in Acute Ischaemic Stroke Patients with Pre-Existing Cognitive Impairment

Autor: Isabela V. P. Ramnarine, Omar W. Rasheed, Peter J. Laud, Arshad Majid, Kirsty A. Harkness, Simon M. Bell

Publikováno v: Life, Vol 13, Iss 4, p 1055 (2023)

Background: Thrombolysis treatment for ischaemic stroke in patients with pre-existing disabilities, including cognitive impairment, remains controversial. Previous studies have suggested functional outcomes post-thrombolysis are worse in patients wit

Externí odkaz: https://doaj.org/article/bc0b5fae0b0b4859b944780ed111a28d

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Akademický článek

Effect of repeated in vivo microCT imaging on the properties of the mouse tibia.

Autor: Sara Oliviero, Mario Giorgi, Peter J Laud, Enrico Dall'Ara

Publikováno v: PLoS ONE, Vol 14, Iss 11, p e0225127 (2019)

In longitudinal studies, in vivo micro-Computed Tomography (microCT) imaging is used to investigate bone changes over time due to interventions in mice. However, ionising radiation can provoke significant variations in bone morphometric parameters. I

Externí odkaz: https://doaj.org/article/d5e8a35f3f9249ba9e96deb70272f514

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Autologous haematopoietic stem cell transplantation as a first-line disease-modifying therapy in patients with 'aggressive' multiple sclerosis

Autor: Basil Sharrack, S Mistry, P J Laud, Harold L. Atkins, Joachim Burman, Richard K. Burt, Marjorie Bowman, Mark S. Freedman, C Innocenti, J Das, John A. Snowden, Riccardo Saccardi, Helen Jessop

Publikováno v: Multiple Sclerosis (Houndmills, Basingstoke, England)

Background: Autologous haematopoietic stem cell transplantation (AHSCT) is an effective treatment for patients with multiple sclerosis (MS) who have highly active disease, despite the use of standard disease-modifying therapies (DMTs). However, the o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e221980aaeda251cb24ffca106701cbc
https://pubmed.ncbi.nlm.nih.gov/33565902

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Assessing proliferation, cell-cycle arrest and apoptotic end points in human buccal punch biopsies for use as pharmacodynamic biomarkers in drug development

Autor: D R Camidge, P J Laud, D Johnstone, A. Hughes, Jim Growcott, John R. Foster, K J Randall, Mike Pemberton

Publikováno v: British Journal of Cancer

Easily accessible normal tissues expressing the same molecular site(s) of drug action as malignant tissue offer an enhanced potential for early proof of anticancer drug mechanism and estimation of the biologically effective dose. Studies were underta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c48a403803166c3e4d15d6127ec9b9b2
http://europepmc.org/articles/PMC2361555

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Plucked human hair as a tissue in which to assess pharmacodynamic end points during drug development studies

Autor: A R Soames, D R Camidge, P J Laud, A. Hughes, C J Sadler, K R Randall, Jayne Wright, Paul D. Smith, John R. Foster

Publikováno v: British Journal of Cancer

We have demonstrated the feasibility of detecting and quantifying six cell-cycle-related nuclear markers (Ki67, pRb, p27, phospho-p27 (phosphorylated p27), phospho-pRb (phosphorylated pRb), phospho-HH3 (phosphorylated histone H3)) in plucked human sc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fb468b24f8d837c9d2d0a112e1b5069
https://doi.org/10.1038/sj.bjc.6602558

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Factors determining the optimal body site and method for obtaining punch biopsies of human skin as a tissue in which to assess pharmacodynamic and pharmacokinetic endpoints in drug development studies

Autor: M. Cockerill, Paul D. Smith, P J Laud, Anna L. Marshall, D R Camidge, M. J. Davies, A. Hughes

Publikováno v: Scopus-Elsevier

There are potential advantages to detecting pharmacodynamic (PD) and pharmacokinetic (PK) endpoints in a tissue-based compartment such as the skin during the development of molecularly targeted drugs. We explored regional differences between inner ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24cc51e486ecad9ad9367cfc227ed4e2
https://pubmed.ncbi.nlm.nih.gov/16032432

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Akademický článek

EMERGENCE OF MULTIDRUG RESISTANT BACTERIA AMONG PATIENTS WITH RESPIRATORY TRACT INFECTIONS.

Autor: Al-Qaissy, Omaima S.¹ omayma.ibraheem1202@sc.uobaghdad.edu.iq, Al-Khafaji, Ahmed S. K.² khafaji@sc.uobaghdad.edu.iq

Publikováno v: Iraqi Journal of Agricultural Sciences. 2023, Vol. 54 Issue 6, p1594-1602. 9p.

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