Zobrazeno 1 - 10
of 11
pro vyhledávání: '"P J D Delhanty"'
Autor:
Elpetra P. M. Timmermans, Joëlle Blankevoort, Guy C. M. Grinwis, Sietske J. Mesu, Ronette Gehring, Patric J. D. Delhanty, Peter E. M. Maas, Ger J. Strous, Jan A. Mol
Publikováno v:
Pharmaceuticals, Vol 17, Iss 10, p 1381 (2024)
Background: The activation of the growth hormone receptor (GHR) is a major determinant of body growth. Defective GHR signaling, as seen in human Laron dwarfism, resulted in low plasma IGF-1 concentrations and limited growth, but also marked absence i
Externí odkaz:
https://doaj.org/article/5b4489a9c71247ea899d31c04259ad42
Autor:
Behiye Özcan, Patric J. D. Delhanty, Martin Huisman, Jenny A. Visser, Sebastian J. Neggers, Aart Jan van der Lely
Publikováno v:
Diabetology & Metabolic Syndrome, Vol 13, Iss 1, Pp 1-7 (2021)
Abstract Background Several studies have demonstrated suppressed levels of acylated (AG) and unacylated ghrelin (UAG) in patients with type 2 diabetes. However, the role of these hormones in type 1 diabetes has not been extensively studied. This stud
Externí odkaz:
https://doaj.org/article/4a2f1cf6a22b4fc78f5d5f0ca9824136
Autor:
Lotte E. Vlug, Patric J. D. Delhanty, Esther G. Neelis, Martin Huisman, Jenny A. Visser, Edmond H. H. M. Rings, René M. H. Wijnen, Sjoerd C. J. Nagelkerke, Merit M. Tabbers, Jessie M. Hulst, Barbara A. E. de Koning
Publikováno v:
Frontiers in Nutrition, Vol 9 (2022)
BackgroundChildren with intestinal failure (IF) require parenteral nutrition (PN). Transition to oral and enteral nutrition (EN) can be difficult also due to abnormal gastrointestinal motility. The gut hormone ghrelin is increased in states of negati
Externí odkaz:
https://doaj.org/article/3084db30791b44a481ef4d22572d4282
Autor:
Behiye Özcan, Pieter J. M. Leenen, Patric J. D. Delhanty, Lucy Y. Baldéon-Rojas, Sebastian J. Neggers, Aart Jan van der Lely
Publikováno v:
Diabetology & Metabolic Syndrome, Vol 9, Iss 1, Pp 1-9 (2017)
Abstract Background Type 2 diabetes (T2D) is associated with reduced numbers and impaired function of circulating angiogenic cells (CAC) which contributes to the progression of atherosclerosis and microvascular disease. Previous studies suggest that
Externí odkaz:
https://doaj.org/article/4ca930cbad894b8daf33962ba2de46f8
Autor:
Roxanne C S van Adrichem, Aart Jan van der Lely, Martin Huisman, Richard A Feelders, Patric J D Delhanty, Wouter W de Herder, Piet Kramer
Publikováno v:
Endocrine Connections, Vol 5, Iss 4, Pp 143-151 (2016)
To date, the value of fasting plasma acylated ghrelin (AG) and unacylated ghrelin (UAG) as potential novel biomarkers in patients with neuroendocrine tumors (NETs) is unknown.The aims of this study are to (i) compare fasting AG and UAG levels between
Externí odkaz:
https://doaj.org/article/954857acb1824615afe1e80edf32fd7e
Autor:
Darko M Stevanovic, Aldo Grefhorst, Axel P N Themmen, Vera Popovic, Joan Holstege, Elize Haasdijk, Vladimir Trajkovic, Aart-Jan van der Lely, Patric J D Delhanty
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e98180 (2014)
Ghrelin, the endogenous growth hormone secretagogue, has an important role in metabolic homeostasis. It exists in two major molecular forms: acylated (AG) and unacylated (UAG). Many studies suggest different roles for these two forms of ghrelin in en
Externí odkaz:
https://doaj.org/article/f9a274f4f63845a2ae70b650233d90f0
Autor:
Karin Blijdorp, Marry M van den Heuvel-Eibrink, Rob Pieters, Annemieke M Boot, Patric J D Delhanty, Aart-Jan van der Lely, Sebastian J C M M Neggers
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43269 (2012)
OBJECTIVE: Obesity, represented by high body mass index (BMI), is a major complication after treatment for childhood cancer. However, it has been shown that high total fat percentage and low lean body mass are more reliable predictors of cardiovascul
Externí odkaz:
https://doaj.org/article/121ebcb4a7d14749969ae6900ee44ff7
Autor:
Patric J D Delhanty, Yuxiang Sun, Jenny A Visser, Anke van Kerkwijk, Martin Huisman, Wilfred F J van Ijcken, Sigrid Swagemakers, Roy G Smith, Axel P N Themmen, Aart-Jan van der Lely
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11749 (2010)
There is increasing evidence that unacylated ghrelin (UAG) improves insulin sensitivity and glucose homeostasis; however, the mechanism for this activity is not fully understood since a UAG receptor has not been discovered.To assess potential mechani
Externí odkaz:
https://doaj.org/article/5ce28b96fc8c4b23a3a76e22b5b88c60
Autor:
P. J. D. Delhanty, A. J. van der Lely
Obesity is an epidemic problem not limited to Western society, but also in emerging industrial nations with large populations, especially in Asia. The connection between the gut and the brain is probably one of the most promising therapeutic targets
Autor:
P. J. D. Delhanty, V. K. M. Han
Publikováno v:
Journal of molecular endocrinology. 9(1)
We have isolated an ovine insulin-like growth factor-binding protein-2 (IGFBP-2) cDNA from an adult sheep cDNA library, to determine the structure of ovine IGFBP-2 and to examine the pattern of IGFBP-2 gene expression in adult sheep tissues. This cDN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1faf3ac466cf8ff9e3a4a16c5b8f2cf4
https://pubmed.ncbi.nlm.nih.gov/1381182
https://pubmed.ncbi.nlm.nih.gov/1381182