Zobrazeno 1 - 10
of 20
pro vyhledávání: '"P J Call"'
Autor:
Xinyu Wu, Margareta Go, Julie V. Nguyen, Nathan W. Kuchel, Bernadine G. C. Lu, Kathleen Zeglinski, Kym N. Lowes, Dale J. Calleja, Jeffrey P. Mitchell, Guillaume Lessene, David Komander, Matthew E. Call, Melissa J. Call
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Papain-like protease (PLpro) is an attractive drug target for SARS-CoV-2 because it is essential for viral replication, cleaving viral poly-proteins pp1a and pp1ab, and has de-ubiquitylation and de-ISGylation activities, affecting innate imm
Externí odkaz:
https://doaj.org/article/f2aa5295a8ff4f9095605b082b38d19a
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
B cells surveil the body for foreign matter using their surface-expressed B cell antigen receptor (BCR), a tetrameric complex comprising a membrane-tethered antibody (mIg) that binds antigens and a signaling dimer (CD79AB) that conveys this interacti
Externí odkaz:
https://doaj.org/article/01e0ede57de04b9e9e729f528e89d11f
Autor:
Rebecca C Abbott, Melinda Iliopoulos, Katherine A Watson, Valeria Arcucci, Margareta Go, Hannah E Hughes‐Parry, Pete Smith, Melissa J Call, Ryan S Cross, Misty R Jenkins
Publikováno v:
Clinical & Translational Immunology, Vol 12, Iss 3, Pp n/a-n/a (2023)
Abstract Objectives Glioblastoma is a highly aggressive and fatal brain malignancy, and effective targeted therapies are required. The combination of standard treatments including surgery, chemotherapy and radiotherapy is not curative. Chimeric antig
Externí odkaz:
https://doaj.org/article/daa67b3f5e504aa1970ae6379d7e3fcb
Autor:
Anthony J. Zacharias MD, Cory J. Call BS, Samantha R. Prince BS, Elizabeth H. G. Turner MD, David C. Goodspeed MD, Andrea M. Spiker MD
Publikováno v:
Video Journal of Sports Medicine, Vol 3 (2023)
Background: Heterotopic ossification (HO), or the abnormal formation of bone in extra-skeletal tissue, is a well-known complication of orthopedic trauma, tendon avulsions, chronic injuries, spinal cord injuries, and soft tissue damage from surgery. H
Externí odkaz:
https://doaj.org/article/22e9f01438e841adadbf68271931c033
Autor:
Assaf Elazar, Nicholas J Chandler, Ashleigh S Davey, Jonathan Y Weinstein, Julie V Nguyen, Raphael Trenker, Ryan S Cross, Misty R Jenkins, Melissa J Call, Matthew E Call, Sarel J Fleishman
Publikováno v:
eLife, Vol 11 (2022)
De novo-designed receptor transmembrane domains (TMDs) present opportunities for precise control of cellular receptor functions. We developed a de novo design strategy for generating programmed membrane proteins (proMPs): single-pass α-helical TMDs
Externí odkaz:
https://doaj.org/article/4c88ae4a5ecb43b5a0ea6b73ec898c18
Autor:
Dale J. Calleja, Nathan Kuchel, Bernadine G. C. Lu, Richard W. Birkinshaw, Theresa Klemm, Marcel Doerflinger, James P. Cooney, Liana Mackiewicz, Amanda E. Au, Yu Q. Yap, Timothy R Blackmore, Kasiram Katneni, Elly Crighton, Janet Newman, Kate E. Jarman, Melissa J. Call, Bernhard C. Lechtenberg, Peter E. Czabotar, Marc Pellegrini, Susan A. Charman, Kym N. Lowes, Jeffrey P. Mitchell, Ueli Nachbur, Guillaume Lessene, David Komander
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
The COVID-19 pandemic continues unabated, emphasizing the need for additional antiviral treatment options to prevent hospitalization and death of patients infected with SARS-CoV-2. The papain-like protease (PLpro) domain is part of the SARS-CoV-2 non
Externí odkaz:
https://doaj.org/article/78066ca793204c13adcbf61221072dfc
Autor:
M. Golombek, N. Williams, N. H. Warner, T. Parker, M. G. Williams, I. Daubar, F. Calef, J. Grant, P. Bailey, H. Abarca, R. Deen, N. Ruoff, J. Maki, A. McEwen, N. Baugh, K. Block, L. Tamppari, J. Call, J. Ladewig, A. Stoltz, W. A. Weems, L. Mora‐Sotomayor, J. Torres, M. Johnson, T. Kennedy, E. Sklyanskiy
Publikováno v:
Earth and Space Science, Vol 7, Iss 10, Pp n/a-n/a (2020)
Abstract Knowing precisely where a spacecraft lands on Mars is important for understanding the regional and local context, setting, and the offset between the inertial and cartographic frames. For the InSight spacecraft, the payload of geophysical an
Externí odkaz:
https://doaj.org/article/609e894d439d48cf8f6d500561a121f6
Autor:
Konstantin Knoblich, Soohyung Park, Mariam Lutfi, Leonie van ’t Hag, Charlotte E. Conn, Shane A. Seabrook, Janet Newman, Peter E. Czabotar, Wonpil Im, Matthew E. Call, Melissa J. Call
Publikováno v:
Cell Reports, Vol 11, Iss 8, Pp 1184-1192 (2015)
The membrane-spanning α helices of single-pass receptors play crucial roles in stabilizing oligomeric structures and transducing biochemical signals across the membrane. Probing intermolecular transmembrane interactions in single-pass receptors pres
Externí odkaz:
https://doaj.org/article/81885ba55d8d4a6e93f0eff1f592297c
Autor:
Robin Wood, Carl Morrow, Clifton E Barry, Wayne A Bryden, Charles J Call, Anthony J Hickey, Charles E Rodes, Thomas J Scriba, Jonathan Blackburn, Chacha Issarow, Nicola Mulder, Jeremy Woodward, Atica Moosa, Vinayak Singh, Valerie Mizrahi, Digby F Warner
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0146658 (2016)
Knowledge of the airborne nature of respiratory disease transmission owes much to the pioneering experiments of Wells and Riley over half a century ago. However, the mechanical, physiological, and immunopathological processes which drive the producti
Externí odkaz:
https://doaj.org/article/ba37c8384a6e451186fb68a770292e02
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69228 (2013)
Peptide presentation by MHC class II is of critical importance to the function of CD4+ T cells. HLA-DM resides in the endosomal pathway and edits the peptide repertoire of newly synthesized MHC class II molecules before they are exported to the cell
Externí odkaz:
https://doaj.org/article/791696a3080d4792aa3a7062923dd3dc