Zobrazeno 1 - 10
of 35
pro vyhledávání: '"P J Bugelski"'
Publikováno v:
Diabetes, Obesity and Metabolism. 3:163-170
Rosiglitazone (BRL-49653-C), a thiazolidinedione, is a potent agonist for the nuclear hormone receptor peroxisome proliferator-activated receptor gamma (PPARgamma). Thiazolidinediones have been reported to induce adipocyte differentiation in vitro an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32604caa5cfa0e2e1acb5134a546230f
https://doi.org/10.1046/j.1463-1326.2001.00117.x
https://doi.org/10.1046/j.1463-1326.2001.00117.x
Autor:
P J Vance, Beth S. Haggarty, Celia C. LaBranche, T K Hart, M M Sauter, P J Bugelski, J Romano, Mark Marsh, James A. Hoxie
Publikováno v:
Journal of Virology. 69:5217-5227
We have described a virus termed CP-MAC, derived from the BK28 molecular clone of simian immunodeficiency virus, that was remarkable for its ability to infect Sup-T1 cells with rapid kinetics, cell fusion, and CD4 down-modulation (C. C. LaBranche, M.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6953150cad9394d3e27c21446bae0c7d
https://doi.org/10.1128/jvi.69.9.5217-5227.1995
https://doi.org/10.1128/jvi.69.9.5217-5227.1995
Publikováno v:
Toxicology in Vitro. 13:567-569
Alamar Blue (AB) reduction is a promising new in vitro assay which is simple to conduct and amenable to repeated measurements and high-throughput screening; however, evaluation with hepatocytes has not been reported. Accordingly, we compared AB reduc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a24daca0d33aee6c73fafbb0c72766d
https://doi.org/10.1016/s0887-2333(99)00037-5
https://doi.org/10.1016/s0887-2333(99)00037-5
Autor:
K. A. Rudnick, A. Volk, R. Tawadros, P. J. Bugelski, S. H. Tam, J. Yang, G. M. Anderson, L. A. Snyder
Publikováno v:
Journal of thrombosis and haemostasis : JTH. 6(2)
Summary. Background: Tissue factor (TF) is expressed widely at the subluminal surface of blood vessels and serves as the primary cellular initiator of the extrinsic pathway of blood coagulation. Lack of TF in mice resulted in lethality in utero, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dff43f375d53db64fec99231ccb1a1d
https://pubmed.ncbi.nlm.nih.gov/18088348
https://pubmed.ncbi.nlm.nih.gov/18088348
Publikováno v:
Humanexperimental toxicology. 21(9-10)
Keliximab is a human-cynomolgus monkey chimeric (Primatized) monoclonal antibody with specificity for human and chimpanzee CD4. As the preclinical safety assessment of biopharmaceuticals requires evaluation in pharmacologically responsive species, co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::952e24828245d9f43fdc9cd821aec404
https://pubmed.ncbi.nlm.nih.gov/12458908
https://pubmed.ncbi.nlm.nih.gov/12458908
Publikováno v:
Diabetes, obesitymetabolism. 3(3)
Rosiglitazone (BRL-49653-C), a thiazolidinedione, is a potent agonist for the nuclear hormone receptor peroxisome proliferator-activated receptor gamma (PPARgamma). Thiazolidinediones have been reported to induce adipocyte differentiation in vitro an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ee160b3f1d2d449cd5f5bbf8eabfdbe3
https://pubmed.ncbi.nlm.nih.gov/11412280
https://pubmed.ncbi.nlm.nih.gov/11412280
Publikováno v:
Pharmaceutical research. 17(10)
Recent advances in combinatorial chemistry and high throughput screens for pharmacologic activity have created an increasing demand for in vitro high throughput screens for toxicological evaluation in the early phases of drug discovery.To develop a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::961ce777839c68b4faba4b84d5a27d9b
https://pubmed.ncbi.nlm.nih.gov/11145233
https://pubmed.ncbi.nlm.nih.gov/11145233
Autor:
F Elcock, J M Birmingham, Peter J. O'Brien, P J Bugelski, A Swain, Mark R Slaughter, R W Greenhill
Publikováno v:
Humanexperimental toxicology. 19(5)
Repeated dosing of acetaminophen (paracetamol) to rats is reported to decrease their sensitivity to its hepatotoxic effects, which are associated with oxidative stress and glutathione depletion. We determined if repeated acetaminophen dosing produced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b43404f067e5363b3b78f5caf0b55b4
https://pubmed.ncbi.nlm.nih.gov/10918522
https://pubmed.ncbi.nlm.nih.gov/10918522
Autor:
P J Bugelski, D M Williams, T K Hart, Danuta J. Herzyk, S Rehm, Richard A. Macia, Allen G. Harmsen, A. Truneh, D G Morgan, E V Gore, A M Badger, B E Maleeff, Patrick J. Wier, S R O'Brien
Publikováno v:
Humanexperimental toxicology. 19(4)
The preclinical safety assessment of biopharmaceuticals necessitates that studies be conducted in species in which the products are pharmacologically active. Monoclonal anti-bodies are a promising class ofbiopharmaceuticals for many disease indicatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b90da81dcf18ff3742a8a0ebf5ef0b14
https://pubmed.ncbi.nlm.nih.gov/10918514
https://pubmed.ncbi.nlm.nih.gov/10918514
Autor:
T W, Hepburn, C B, Davis, J J, Urbanski, B R, Smith, W H, Schaefer, M A, Carbonaro, P J, Bugelski
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 23(10)
Recombinant soluble CD4 (sT4; mol. wt. 45,000) has been studied extensively in Sprague-Dawley rats, and substantial renal processing has been indicated. In rats and monkeys, renal filtration and precipitation of sT4 in the distal nephron caused tubul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5e7c46cc9621c9ea1a5dcbc791e5f164
https://pubmed.ncbi.nlm.nih.gov/8654191
https://pubmed.ncbi.nlm.nih.gov/8654191