Výsledky vyhledávání

Akademický článek

Sequestration of histidine kinases by non-cognate response regulators establishes a threshold level of stimulation for bacterial two-component signaling

Autor: Gaurav D. Sankhe, Rubesh Raja, Devendra Pratap Singh, Sneha Bheemireddy, Subinoy Rana, P. J. Athira, Narendra M. Dixit, Deepak Kumar Saini

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)

Abstract Bacterial two-component systems (TCSs) consist of a sensor histidine kinase (HK) that perceives a specific signal, and a cognate response regulator (RR) that modulates the expression of target genes. Positive autoregulation improves TCS sens

Externí odkaz: https://doaj.org/article/f062305b2f704090bd0e7053941ff8d8

Zobrazit plný text záznamu

Akademický článek

Acetylation of Response Regulator Protein MtrA in M. tuberculosis Regulates Its Repressor Activity

Autor: Krishna Kumar Singh, P. J. Athira, Neerupma Bhardwaj, Devendra Pratap Singh, Uchenna Watson, Deepak Kumar Saini

Publikováno v: Frontiers in Microbiology, Vol 11 (2021)

MtrA is an essential response regulator (RR) protein in M. tuberculosis, and its activity is modulated after phosphorylation from its sensor kinase MtrB. Interestingly, many regulatory effects of MtrA have been reported to be independent of its phosp

Externí odkaz: https://doaj.org/article/ad5590ed29c34094a991bf486dc3da8f

Zobrazit plný text záznamu

Akademický článek

A high-frequency single nucleotide polymorphism in the MtrB sensor kinase in clinical strains of Mycobacterium tuberculosis alters its biochemical and physiological properties.

Autor: Waturuocha, Uchenna Watson^1,2 (AUTHOR), P. J., Athira² (AUTHOR), Singh, Krishna Kumar² (AUTHOR), Malhotra, Vandana³ (AUTHOR), Krishna, M. S.¹ (AUTHOR), Saini, Deepak Kumar^2,4 (AUTHOR) deepaksaini@iisc.ac.in

Publikováno v: PLoS ONE. 9/16/2021, Vol. 16 Issue 9, p1-18. 18p.

Zobrazit plný text záznamu

A high-frequency single nucleotide polymorphism in the MtrB sensor kinase in clinical strains of Mycobacterium tuberculosis alters its biochemical and physiological properties

Autor: Krishna Kumar Singh, M. S. Krishna, Vandana Malhotra, Uchenna Watson Waturuocha, Deepak Kumar Saini, P J Athira

Publikováno v: PLoS ONE
PLoS ONE, Vol 16, Iss 9, p e0256664 (2021)

The DNA polymorphisms found in clinical strains ofMycobacterium tuberculosisdrive altered physiology, virulence, and pathogenesis in them. Although the lineages of these clinical strains can be traced back to common ancestor/s, there exists a plethor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88c1ef2dda44a00621e90a0a0cd19f7d
https://doi.org/10.1371/journal.pone.0256664

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání