Zobrazeno 1 - 10
of 469
pro vyhledávání: '"P J, van Diest"'
Autor:
Marc Aubreville, Frauke Wilm, Nikolas Stathonikos, Katharina Breininger, Taryn A. Donovan, Samir Jabari, Mitko Veta, Jonathan Ganz, Jonas Ammeling, Paul J. van Diest, Robert Klopfleisch, Christof A. Bertram
Publikováno v:
Scientific Data, Vol 11, Iss 1, Pp 1-3 (2024)
Externí odkaz:
https://doaj.org/article/79e04115ad314378bf65aa84a519e65d
Autor:
Antoine A. Khalil, Daan Smits, Peter D. Haughton, Thijs Koorman, Karin A. Jansen, Mathijs P. Verhagen, Mirjam van der Net, Kitty van Zwieten, Lotte Enserink, Lisa Jansen, Abdelrahman G. El-Gammal, Daan Visser, Milena Pasolli, Max Tak, Denise Westland, Paul J. van Diest, Cathy B. Moelans, M. Guy Roukens, Sandra Tavares, Anne-Marie Fortier, Morag Park, Riccardo Fodde, Martijn Gloerich, Fried. J. T. Zwartkruis, Patrick WB. Derksen, Johan de Rooij
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Dense and aligned Collagen I fibers are associated with collective cancer invasion led by protrusive tumor cells, leader cells. In some breast tumors, a population of cancer cells (basal-like cells) maintain several epithelial characteristic
Externí odkaz:
https://doaj.org/article/50e49d8f27e74b6aa43d0874b11c6389
Autor:
L. M. Janssen, M. H. A. Janse, B. B. L. Penning de Vries, B. H. M. van der Velden, E. J. M. Wolters-van der Ben, S. M. van den Bosch, A. Sartori, C. Jovelet, M. J. Agterof, D. Ten Bokkel Huinink, E. W. Bouman-Wammes, P. J. van Diest, E. van der Wall, S. G. Elias, K. G. A. Gilhuijs
Publikováno v:
npj Breast Cancer, Vol 10, Iss 1, Pp 1-10 (2024)
Abstract Accurate prediction of response to neoadjuvant chemotherapy (NAC) can help tailor treatment to individual patients’ needs. Little is known about the combination of liquid biopsies and computer extracted features from multiparametric magnet
Externí odkaz:
https://doaj.org/article/a5a415b482d0434db9b31cb080411cde
Autor:
Yuwei Wang, Gwen M. H. E. Dackus, Efraim H. Rosenberg, Sten Cornelissen, Leonora W. de Boo, Annegien Broeks, Wim Brugman, Terry W. S. Chan, Paul J. van Diest, Michael Hauptmann, Natalie D. ter Hoeve, Olga I. Isaeva, Vincent M. T. de Jong, Katarzyna Jóźwiak, Roelof J. C. Kluin, Marleen Kok, Esther Koop, Petra M. Nederlof, Mark Opdam, Philip C. Schouten, Sabine Siesling, Charlaine van Steenis, Adri C. Voogd, Willem Vreuls, Roberto F. Salgado, Sabine C. Linn, Marjanka K. Schmidt
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Background Due to the abundant usage of chemotherapy in young triple-negative breast cancer (TNBC) patients, the unbiased prognostic value of BRCA1-related biomarkers in this population remains unclear. In addition, whether BRCA1-related bio
Externí odkaz:
https://doaj.org/article/ddff242b9c864f39864f3885aee7bad4
Autor:
Matthew E. Randolph, Marwa Afifi, Aparna Gorthi, Rachel Weil, Breelyn A. Wilky, Joshua Weinreb, Paul Ciero, Natalie ter Hoeve, Paul J. van Diest, Venu Raman, Alexander J.R. Bishop, David M. Loeb
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108925- (2024)
Summary: We previously demonstrated that RNA helicase DDX3X (DDX3) can be a therapeutic target in Ewing sarcoma (EWS), but its role in EWS biology remains unclear. The present work demonstrates that DDX3 plays a unique role in DNA damage repair (DDR)
Externí odkaz:
https://doaj.org/article/feee3811ebda42bda24ca7644f0ec5fe
Autor:
Marc Aubreville, Frauke Wilm, Nikolas Stathonikos, Katharina Breininger, Taryn A. Donovan, Samir Jabari, Mitko Veta, Jonathan Ganz, Jonas Ammeling, Paul J. van Diest, Robert Klopfleisch, Christof A. Bertram
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-12 (2023)
Abstract The prognostic value of mitotic figures in tumor tissue is well-established for many tumor types and automating this task is of high research interest. However, especially deep learning-based methods face performance deterioration in the pre
Externí odkaz:
https://doaj.org/article/83c2fd0cf0ca41988f96b88f3255e1a0
Autor:
Iman J. Schultz, Yvette Zimmerman, Cathy B. Moelans, Marcin Chrusciel, Jan Krijgh, Paul J. van Diest, Ilpo T. Huhtaniemi, Herjan J. T. Coelingh Bennink
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
BackgroundExpression of Zona Pellucida glycoprotein 3 (ZP3) in healthy tissue is restricted to the extracellular Zona Pellucida layer surrounding oocytes of ovarian follicles and to specific cells of the spermatogenic lineage. Ectopic expression of Z
Externí odkaz:
https://doaj.org/article/8ee16e995e5c4eb683f816de22705973
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 3, p 1812 (2024)
Patients with pathological nipple discharge (PND) often undergo local surgical procedures because standard radiologic imaging fails to identify the underlying cause. MicroRNA (MiRNA) expression analysis of nipple fluid holds potential for distinguish
Externí odkaz:
https://doaj.org/article/b575a479712847fdab0eb0adb614103f
Autor:
L. M. Janssen, B. M. den Dekker, K. G. A. Gilhuijs, P. J. van Diest, E. van der Wall, S. G. Elias
Publikováno v:
npj Breast Cancer, Vol 8, Iss 1, Pp 1-7 (2022)
Abstract This meta-analysis aimed to estimate and compare sensitivity, specificity, positive- (PPV) and negative predictive value (NPV) of magnetic resonance imaging (MRI) for predicting pathological complete remission (pCR) after neoadjuvant chemoth
Externí odkaz:
https://doaj.org/article/af750050f9b648d6856c3557a9eda8c7
Deep learning-based breast cancer grading and survival analysis on whole-slide histopathology images
Autor:
Suzanne C. Wetstein, Vincent M. T. de Jong, Nikolas Stathonikos, Mark Opdam, Gwen M. H. E. Dackus, Josien P. W. Pluim, Paul J. van Diest, Mitko Veta
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Breast cancer tumor grade is strongly associated with patient survival. In current clinical practice, pathologists assign tumor grade after visual analysis of tissue specimens. However, different studies show significant inter-observer varia
Externí odkaz:
https://doaj.org/article/b59fee3b27c34ccfb9661b4cad529743