Výsledky vyhledávání - "P J, van Bladeren"

Akademický článek

Exploitation of carbon surface functionality toward additive‐free formation of gold nanocuboids suitable for sensitive assay of N‐acetylcysteine in pharmaceutical formulations.

Autor: Murphy, Eoghain¹ (AUTHOR), Guin, Saurav K.¹ (AUTHOR), Lapiy, Alexandra¹ (AUTHOR), Camisasca, Adalberto² (AUTHOR), Giordani, Silvia² (AUTHOR), Dempsey, Eithne¹ (AUTHOR) eithne.dempsey@mu.ie

Publikováno v: Electrochemical Science Advances. Dec2024, Vol. 4 Issue 6, p1-13. 13p.

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Glutathione-dependent biotransformation of the alkylating drug thiotepa and transport of its metabolite monoglutathionylthiotepa in human MCF-7 breast cancer cells

Autor: N H, Cnubben, A J, Rommens, M J, Oudshoorn, P J, Van Bladeren

Publikováno v: Cancer research. 58(20)

In this study, the role of glutathione S-transferase (GST) P1-1, the cellular reduced glutathione (GSH) status, and ATP-dependent efflux pumps in the cellular glutathione-dependent biotransformation of thiotepa and transport of the main metabolite mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a32559573266bfb311355e096e895e38
https://pubmed.ncbi.nlm.nih.gov/9788613

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Disposition of 1,2-[14C]Dibromoethane in male Wistar rats

Autor: L W, Wormhoudt, A M, Hissink, J N, Commandeur, P J, van Bladeren, N P, Vermeulen

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 26(5)

In this study the disposition of 1,2-[14C]dibromoethane (1, 2-[14C]DBE) was investigated in male Wistar rats. 1,2-DBE is a cytotoxic and carcinogenic compound that has been used as an additive in leaded gasoline and as a fumigant. 1,2-[14C]DBE was ad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::01e8eb001ce8167ff9cd4e692cf5fce2
https://pubmed.ncbi.nlm.nih.gov/9571225

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Exposure of humans to complex chemical mixtures: hazard identification and risk assessment

Autor: V J, Feron, J P, Groten, P J, van Bladeren

Publikováno v: Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement. 20

A complex chemical mixture is defined as a mixture that consists of tens, hundreds or thousands of chemicals, and of which the composition is qualitatively and quantitatively not fully known. In contrast, a simple mixture consists of a relatively sma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::91b1a9285e4bdcd4edfa55867924f568
https://pubmed.ncbi.nlm.nih.gov/9442308

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Inhibition of glutathione conjugation by glutathione analogues in the perfused rat liver. Effect of esterification on the potency of gamma-L-glutamyl-alpha-(D-2-aminoadipyl)-N-2-heptylamine

Autor: S, Ouwerkerk-Mahadevan, R G, Tirona, R A, Ripping, J H, Ploemen, P J, van Bladeren, K S, Pang, J H, van Boom, G J, Mulder

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 25(10)

To assess the role of GST's (glutathione S-transferases) in the (de)toxification of their substrates, an in vivo active inhibitor based on the structure of glutathione (GSH), gamma-L-glutamyl-alpha-(D-2-aminoadipyl)-N-2-heptylamine monoethyl ester (E

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c67a7bf7d730589303d1fd525025e374
https://pubmed.ncbi.nlm.nih.gov/9321516

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Urinary thiodiacetic acid. A selective biomarker for the cytochrome P450-catalyzed oxidation of 1,2-dibromoethane in the rat

Autor: L W, Wormhoudt, J N, Commandeur, J H, Ploemen, R S, Abdoelgafoer, A, Makansi, P J, Van Bladeren, N P, Vermeulen

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 25(4)

1,2-Dibromoethane (1,2-DBE) is a carcinogenic compound that is metabolized both by cytochrome P450 (P450) and glutathione S-transferase (GST) enzymes, and that has been used by us as a model compound to study interindividual variability in biotransfo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::aaaa1e23f2446feaa34e690ff5c0dec5
https://pubmed.ncbi.nlm.nih.gov/9107551

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Identification of multiple target sites for a glutathione conjugate on glutathione-S-transferase by matrix-assisted laser desorption/ionization mass spectrometry

Autor: S, Jespersen, J H, Ploemen, P J, van Bladeren, W M, Niessen, U R, Tjaden, J, van der Greef

Publikováno v: Journal of mass spectrometry : JMS. 31(1)

A mass spectrometric method providing qualitative site-specific information regarding covalent modification of proteins is described. The method involves comparison of unmodified and modified proteins by matrix-assisted laser desorption/ionization ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a18e843b315f1d09d63f011bbf25c0d6
https://pubmed.ncbi.nlm.nih.gov/8925505

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