Zobrazeno 1 - 10
of 22
pro vyhledávání: '"P J, Voshol"'
Autor:
Benoit Bilanges, Samira Alliouachene, Wayne Pearce, Daniele Morelli, Gyorgy Szabadkai, Yuen-Li Chung, Gaëtan Chicanne, Colin Valet, Julia M. Hill, Peter J. Voshol, Lucy Collinson, Christopher Peddie, Khaled Ali, Essam Ghazaly, Vinothini Rajeeve, Georgios Trichas, Shankar Srinivas, Claire Chaussade, Rachel S. Salamon, Jonathan M. Backer, Cheryl L. Scudamore, Maria A. Whitehead, Erin P. Keaney, Leon O. Murphy, Robert K. Semple, Bernard Payrastre, Sharon A. Tooze, Bart Vanhaesebroeck
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Vps34 is a lipid kinase conserved from yeast to humans and involved in in intracellular vesicular trafficking and autophagy. Here Bilanges et al. show that inhibition of this kinase in mice improves glucose tolerance and diet-induced steatosis by mod
Externí odkaz:
https://doaj.org/article/555f2b0adcb149a18a070a3da3035320
Autor:
Mark A. Smith, Loukia Katsouri, Elaine E. Irvine, Mohammed K. Hankir, Silvia M.A. Pedroni, Peter J. Voshol, Matthew W. Gordon, Agharul I. Choudhury, Angela Woods, Antonio Vidal-Puig, David Carling, Dominic J. Withers
Publikováno v:
Cell Reports, Vol 11, Iss 3, Pp 335-343 (2015)
Hypothalamic ribosomal S6K1 has been suggested as a point of convergence for hormonal and nutrient signals in the regulation of feeding behavior, bodyweight, and glucose metabolism. However, the long-term effects of manipulating hypothalamic S6K1 sig
Externí odkaz:
https://doaj.org/article/4a2236d9eaa5490ca1c6f7a34e0b6d8e
Autor:
Caterina Constantinou, Diogenis Mpatsoulis, Anastasios Natsos, Peristera-Ioanna Petropoulou, Evangelia Zvintzou, Abdulmaged M. Traish, Peter J. Voshol, Iordanes Karagiannides, Kyriakos E. Kypreos
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 7, Pp 1434-1447 (2014)
Here, we investigated how LDL receptor deficiency (Ldlr−/−) modulates the effects of testosterone on obesity and related metabolic dysfunctions. Though sham-operated Ldlr−/− mice fed Western-type diet for 12 weeks became obese and showed dist
Externí odkaz:
https://doaj.org/article/23eccf5986c14aadb10bc36147997ff5
Autor:
Claudia P. Coomans, Janine J. Geerling, Bruno Guigas, Anita M. van den Hoek, Edwin T. Parlevliet, D. Margriet Ouwens, Hanno Pijl, Peter J. Voshol, Patrick C.N. Rensen, Louis M. Havekes, Johannes A. Romijn
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 9, Pp 1712-1722 (2011)
Insulin signaling in the central nervous system (CNS) is required for the inhibitory effect of insulin on glucose production. Our aim was to determine whether the CNS is also involved in the stimulatory effect of circulating insulin on the tissue-spe
Externí odkaz:
https://doaj.org/article/e28774ae54384d0baefe6731789094a9
Autor:
Janna A. van Diepen, Man C. Wong, Bruno Guigas, Jasper Bos, Rinke Stienstra, Leanne Hodson, Steven E. Shoelson, Jimmy F.P. Berbée, Patrick C.N. Rensen, Johannes A. Romijn, Louis M. Havekes, Peter J. Voshol
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 5, Pp 942-950 (2011)
Low-grade inflammation in different tissues, including activation of the nuclear factor κB pathway in liver, is involved in metabolic disorders such as type 2 diabetes and cardiovascular diseases (CVDs). In this study, we investigated the relation b
Externí odkaz:
https://doaj.org/article/ea0280a294cd4217a1ff5480e6afc299
Autor:
Silvia Bijland, Sjoerd A.A van den Berg, Peter J. Voshol, Anita M. van den Hoek, Hans M.G Princen, Louis M. Havekes, Patrick C.N Rensen, Ko Willems van Dijk
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 1, Pp 97-102 (2010)
The cholesteryl ester transfer protein (CETP) facilitates the bidirectional transfer of cholesteryl esters and triglycerides (TG) between HDL and (V)LDL. By shifting cholesterol in plasma from HDL to (V)LDL in exchange for VLDL-TG, CETP aggravates at
Externí odkaz:
https://doaj.org/article/ffb3f129e2e14e0d904151c32f1103eb
Autor:
Gery Gerritsen, Caroline C. van der Hoogt, Frank G. Schaap, Peter J. Voshol, Kyriakos E. Kypreos, Nobuyo Maeda, Albert K. Groen, Louis M. Havekes, Patrick C.N. Rensen, Ko Willems van Dijk
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 5, Pp 1048-1055 (2008)
Apolipoprotein E2 (apoE2)-associated hyperlipidemia is characterized by a disturbed clearance of apoE2-enriched VLDL remnants. Because excess apoE2 inhibits LPL-mediated triglyceride (TG) hydrolysis in vitro, we investigated whether direct or indirec
Externí odkaz:
https://doaj.org/article/639562903e8f4acdaf8cfbef49ef64d8
Autor:
Corina J.A. Moen, Aart P. Tholens, Peter J. Voshol, Willeke de Haan, Louis M. Havekes, Peter Gargalovic, Aldons J. Lusis, Ko Willems van Dȳk, Rune R. Frants, Marten H. Hofker, Patrick C.N. Rensen
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 10, Pp 2182-2192 (2007)
The Hyplip2 congenic mouse strain contains part of chromosome 15 from MRL/MpJ on the BALB/cJ background. Hyplip2 mice show increased plasma levels of cholesterol and predominantly triglycerides (TGs) and are susceptible to diet-induced atherosclerosi
Externí odkaz:
https://doaj.org/article/0b85f06617064831b97c73353612aa91
Autor:
Audrey C A Cleuren, Vicky T Blankevoort, Janna A van Diepen, Daniël Verhoef, Peter J Voshol, Pieter H Reitsma, Bart J M van Vlijmen
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0131859 (2015)
Obesity is associated with a hypercoagulable state and increased risk for thrombotic cardiovascular events.Establish the onset and reversibility of the hypercoagulable state during the development and regression of nutritionally-induced obesity in mi
Externí odkaz:
https://doaj.org/article/a06c9576e6704ba9ba6a1579c9ac5cc9
Autor:
Jeltje R. Goudriaan, Marion A.M. den Boer, Patrick C.N. Rensen, Maria Febbraio, Folkert Kuipers, Johannes A. Romijn, Louis M. Havekes, Peter J. Voshol
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 10, Pp 2175-2181 (2005)
CD36 is involved in high-affinity peripheral FFA uptake. CD36-deficient (cd36−/−) mice exhibit increased plasma FFA and triglyceride (TG) levels. The aim of the present study was to elucidate the cause of the increased plasma TG levels in cd36−
Externí odkaz:
https://doaj.org/article/5052ddc6249c4f08a0b2434d719c69b0