Zobrazeno 1 - 10
of 41
pro vyhledávání: '"P J, Steinbach"'
Autor:
Chu-Yu Lee, Daniel R. Thedens, Olivia Lullmann, Emily J. Steinbach, Michelle R. Tamplin, Michael S. Petronek, Isabella M. Grumbach, Bryan G. Allen, Lyndsay A. Harshman, Vincent A. Magnotta
Publikováno v:
Tomography, Vol 10, Iss 7, Pp 1074-1088 (2024)
The MR transverse relaxation rate, R2*, has been widely used to detect iron and myelin content in tissue. However, it is also sensitive to macroscopic B0 inhomogeneities. One approach to correct for the B0 effect is to fit gradient-echo signals with
Externí odkaz:
https://doaj.org/article/6da44ec3a8c1419c9d350f4b81318e7f
Autor:
Adam J. Rauckhorst, Gabriela Vasquez Martinez, Gabriel Mayoral Andrade, Hsiang Wen, Ji Young Kim, Aaron Simoni, Claudia Robles-Planells, Kranti A. Mapuskar, Prerna Rastogi, Emily J. Steinbach, Michael L. McCormick, Bryan G. Allen, Navjot S. Pabla, Ashley R. Jackson, Mitchell C. Coleman, Douglas R. Spitz, Eric B. Taylor, Diana Zepeda-Orozco
Publikováno v:
Molecular Metabolism, Vol 79, Iss , Pp 101849- (2024)
Objective: Energy-intensive kidney reabsorption processes essential for normal whole-body function are maintained by tubular epithelial cell metabolism. Although tubular metabolism changes markedly following acute kidney injury (AKI), it remains uncl
Externí odkaz:
https://doaj.org/article/3fd3e25948fb47dd89066773a4e94c07
Autor:
Andrea Mussini, Pietro Delcanale, Melissa Berni, Stefano Pongolini, Mireia Jordà-Redondo, Montserrat Agut, Peter J. Steinbach, Santi Nonell, Stefania Abbruzzetti, Cristiano Viappiani
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 5751 (2024)
Modular supramolecular complexes, where different proteins are assembled to gather targeting capability and photofunctional properties within the same structures, are of special interest for bacterial photodynamic inactivation, given their inherent b
Externí odkaz:
https://doaj.org/article/a3e9fb8854e242eebae7e744c3afca4d
Autor:
Angela Rivera, Won Young Lim, Eunchong Park, Patrick A. Dome, Michael J. Hoy, Ivan Spasojevic, Sheng Sun, Anna Floyd Averette, Sergio Pina-Oviedo, Praveen R. Juvvadi, William J. Steinbach, Maria Ciofani, Jiyong Hong, Joseph Heitman
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT Fungal infections are of mounting global concern, and the current limited treatment arsenal poses challenges when treating such infections. In particular, infections by Cryptococcus neoformans are associated with high mortality, emphasizing
Externí odkaz:
https://doaj.org/article/ce0b324bccb346759ee1b133f5211833
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
Chronic kidney disease (CKD) affects more than 37 million American adults. Adult-onset CKD is typically attributed to acquired comorbidities such as aging, type II diabetes, and cardiovascular disease. Conversely, congenital abnormalities of the kidn
Externí odkaz:
https://doaj.org/article/60309c39d2984c5db06c68541e5d5286
Autor:
Sophie M.-C. Gobeil, Benjamin G. Bobay, Praveen R. Juvvadi, D. Christopher Cole, Joseph Heitman, William J. Steinbach, Ronald A. Venters, Leonard D. Spicer
Publikováno v:
mBio, Vol 12, Iss 6 (2021)
ABSTRACT Calcineurin is a critical enzyme in fungal pathogenesis and antifungal drug tolerance and, therefore, an attractive antifungal target. Current clinically accessible calcineurin inhibitors, such as FK506, are immunosuppressive to humans, so e
Externí odkaz:
https://doaj.org/article/0963e345cfb74f47bf957fdadaef28c6
Publikováno v:
Journal of Fungi, Vol 8, Iss 12, p 1281 (2022)
Calcineurin (CN) is an attractive antifungal target as it is critical for growth, stress response, drug resistance, and virulence in fungal pathogens. The immunosuppressive drugs, tacrolimus (FK506) and cyclosporin A (CsA), are fungistatic and specif
Externí odkaz:
https://doaj.org/article/6872ee6340a742b0881e3265c8ffab07
Autor:
Praveen R. Juvvadi, David Fox, Benjamin G. Bobay, Michael J. Hoy, Sophie M. C. Gobeil, Ronald A. Venters, Zanetta Chang, Jackie J. Lin, Anna Floyd Averette, D. Christopher Cole, Blake C. Barrington, Joshua D. Wheaton, Maria Ciofani, Michael Trzoss, Xiaoming Li, Soo Chan Lee, Ying-Lien Chen, Mitchell Mutz, Leonard D. Spicer, Maria A. Schumacher, Joseph Heitman, William J. Steinbach
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
FK506 is a potential antifungal compound that inhibits calcineurin, but it also has immunosuppressive activity. Here, Juvvadi et al. report the structure of FK506 in complex with the FK506-binding protein FKPB12 and calcineurin, and design a less imm
Externí odkaz:
https://doaj.org/article/4b8d65315776423982c1bea6612cead9
Autor:
E. Keats Shwab, Praveen R. Juvvadi, Greg Waitt, Shareef Shaheen, John Allen, Erik J. Soderblom, Benjamin G. Bobay, Yohannes G. Asfaw, M. Arthur Moseley, William J. Steinbach
Publikováno v:
mBio, Vol 11, Iss 6 (2020)
ABSTRACT Protein kinase A (PKA) signaling plays a critical role in the growth and development of all eukaryotic microbes. However, few direct targets have been characterized in any organism. The fungus Aspergillus fumigatus is a leading infectious ca
Externí odkaz:
https://doaj.org/article/3ece9604418c42c0a8b4f8936774ea35
Autor:
E. Keats Shwab, Praveen R. Juvvadi, Shareef K. Shaheen, John Allen, Greg Waitt, Erik J. Soderblom, Yohannes G. Asfaw, M. Arthur Moseley, William J. Steinbach
Publikováno v:
Journal of Fungi, Vol 8, Iss 4, p 354 (2022)
Cellular recycling via autophagy-associated proteins is a key catabolic pathway critical to invasive fungal pathogen growth and virulence in the nutrient-limited host environment. Protein kinase A (PKA) is vital for the growth and virulence of numero
Externí odkaz:
https://doaj.org/article/5d1e3deab50c4838b224a9b4d520e93f