Zobrazeno 1 - 5
of 5
pro vyhledávání: '"P J, Schreur"'
Autor:
C H, Lin, S R, Haadsma-Svensson, R A, Lahti, R B, McCall, M F, Piercey, P J, Schreur, P F, Von Voigtlander, M W, Smith, C G, Chidester
Publikováno v:
Journal of Medicinal Chemistry. 36:1053-1068
The synthesis and structure-activity relationships (SAR) of 2,3,3a,4,5,9b-hexahydro-1H-benz[e]indole derivatives (3) are described. These compounds are conformationally restricted, angular tricyclic analogs of 2-aminotetralin. The synthesis was achie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::915eed22f4246a6b69375ea3c44c52a9
https://doi.org/10.1021/jm00060a014
https://doi.org/10.1021/jm00060a014
Autor:
K M, Merchant, G S, Gill, D W, Harris, R M, Huff, M J, Eaton, K, Lookingland, B S, Lutzke, R B, Mccall, M F, Piercey, P J, Schreur, V H, Sethy, M W, Smith, K A, Svensson, A H, Tang, P F, Vonvoigtlander, R E, Tenbrink
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 279(3)
Dopamine D2-like receptors play an important role in the pharmacotherapy of psychotic disorders. Molecular and cellular techniques have identified distinct gene products (D2-long, D2-short, D3 and D4) displaying the D2 receptor pharmacology. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::259d6fa65fe3dc2859628be188e3cc22
https://pubmed.ncbi.nlm.nih.gov/8968364
https://pubmed.ncbi.nlm.nih.gov/8968364
Autor:
R B, McCall, A G, Romero, M J, Bienkowski, D W, Harris, J C, McGuire, M F, Piercey, M E, Shuck, M W, Smith, K A, Svensson, P J, Schreur
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 271(2)
The purpose of the present study was to characterize U-92016A [(+)-R)-2-cyano-N,N-dipropyl-8-amino-6,7,8,9-tetrahydro-3H-benz[e] indole] as a 5-hydroxytryptamine (5-HT)1A receptor agonist and to compare its activity with that of standard 5-HT1A recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ce0e1872980bb499ace2f04a9d431c0d
https://pubmed.ncbi.nlm.nih.gov/7965808
https://pubmed.ncbi.nlm.nih.gov/7965808
Autor:
M F, Piercey, A H, Tang, R A, Lahti, P F, VonVoigtlander, P J, Schreur, R B, McCall, J T, Lum-Ragan, W E, Hoffmann, S R, Franklin, R A, Code
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 268(3)
U-67413B (4-hydroxydipropylaminodihydrophenalene) bound with high affinity to both 5-hydroxytryptamine (HT)1A and D2-dopamine (DA) receptor sites. U-67413B depressed 5-HT and DA cell firing rates and depressed synthesis of both neurotransmitters. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4f2db64e33d1b463083a75390ed65e81
https://pubmed.ncbi.nlm.nih.gov/7908053
https://pubmed.ncbi.nlm.nih.gov/7908053
Autor:
J P, McGovren, M G, Williams, A H, Tang, P F, VonVoigtlander, M F, Piercey, F J, Einspahr, P J, Schreur
Publikováno v:
Research communications in chemical pathology and pharmacology. 63(2)
The investigational amino acid antitumor agent, acivicin, has been reported to cause dose-related and reversible CNS toxicity in humans characterized by sedation, ataxia, hallucinations, personality changes, and other symptoms. In a series of studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9d94826bb738e4a0683c6618a38acd5d
https://pubmed.ncbi.nlm.nih.gov/2711026
https://pubmed.ncbi.nlm.nih.gov/2711026