Zobrazeno 1 - 10
of 10
pro vyhledávání: '"P J, Pfaffinger"'
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0248688 (2021)
Voltage-gated potassium (Kv) channels regulate the membrane potential and conductance of excitable cells to control the firing rate and waveform of action potentials. Even though Kv channels have been intensely studied for over 70 year, surprisingly
Externí odkaz:
https://doaj.org/article/24679e5e892048c9a150ee57a209f85c
Modulatory mechanisms and multiple functions of somatodendritic A-type K+ channel auxiliary subunits
Autor:
Henry Hungtao Jerng, Paul J Pfaffinger
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 8 (2014)
Auxiliary subunits are non-conducting, modulatory components of the multi-protein ion channel complexes that underlie normal neuronal signaling. They interact with the pore-forming α-subunits to modulate surface distribution, ion conductance, and ch
Externí odkaz:
https://doaj.org/article/176ed7f2bc0b4911af0624da01d57bfa
Autor:
Henry H Jerng, Paul J Pfaffinger
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e93315 (2014)
Reactive oxygen species (ROS) regulate ion channels, modulate neuronal excitability, and contribute to the etiology of neurodegenerative disorders. ROS differentially suppress fast "ball-and-chain" N-type inactivation of cloned Kv1 and Kv3 potassium
Externí odkaz:
https://doaj.org/article/ec2e6036a4ce4c06aee6797faea09645
Autor:
Brian M Nadin, Paul J Pfaffinger
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60831 (2013)
Dipeptidyl Peptidase-like Protein 6 (DPP6) is widely expressed in the brain where it co-assembles with Kv4 channels and KChIP auxiliary subunits to regulate the amplitude and functional properties of the somatodendritic A-current, ISA. Here we show t
Externí odkaz:
https://doaj.org/article/bb329690424b44268b09fc0757ef3a6d
Autor:
Alison Prince, Paul J Pfaffinger
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e62695 (2013)
N-type inactivation is produced by the binding of a potassium channel's N-terminus within the open pore, blocking conductance. Previous studies have found that introduction of negative charges into N-terminal inactivation domains disrupts inactivatio
Externí odkaz:
https://doaj.org/article/655ddc1bd27044119abd48a3bbdada27
Autor:
Paul J Pfaffinger
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79891 (2013)
N-type inactivation occurs when the N-terminus of a potassium channel binds into the open pore of the channel. This study examined the relationship between activation and steady state inactivation for mutations affecting the N-type inactivation prope
Externí odkaz:
https://doaj.org/article/2b446c37e1614056b9a1d64d4aa90e9c
Autor:
Henry H Jerng, Paul J Pfaffinger
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38205 (2012)
Dipeptidyl peptidase-like protein 6 (DPP6) proteins co-assemble with Kv4 channel α-subunits and Kv channel-interacting proteins (KChIPs) to form channel protein complexes underlying neuronal somatodendritic A-type potassium current (I(SA)). DPP6 pro
Externí odkaz:
https://doaj.org/article/b30d0bc97e0347d484d44bd210c965b1
Publikováno v:
Nature structural biology. 7(5)
The T1 domain, a highly conserved cytoplasmic portion at the N-terminus of the voltage-dependent K+ channel (Kv) alpha-subunit, is responsible for driving and regulating the tetramerization of the alpha-subunits. Here we report the identification of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4040f0fca708e2bee188227a97dcb708
https://pubmed.ncbi.nlm.nih.gov/10802739
https://pubmed.ncbi.nlm.nih.gov/10802739
Publikováno v:
Nature structural biology. 6(1)
The N-terminal, cytoplasmic tetramerization domain (T1) of voltage-gated K+ channels encodes molecular determinants for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. Crystal structures of T1 tetramers from Shaw an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a09ac1bc8a5049073698ecabd66669a5
https://pubmed.ncbi.nlm.nih.gov/9886290
https://pubmed.ncbi.nlm.nih.gov/9886290
Publikováno v:
Society of General Physiologists series. 45
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::48ec4bdae16fd632f87f45770abd734e
https://pubmed.ncbi.nlm.nih.gov/2165636
https://pubmed.ncbi.nlm.nih.gov/2165636