Výsledky vyhledávání - "P J, O'Hanlon"

Akademický článek

A pharmacokinetic framework describing antibiotic adsorption to cardiopulmonary bypass devices

Autor: Conor J. O'Hanlon, Nick Holford, Brian J. Anderson, Mark Greaves, Lee Blackburn, Malcolm D. Tingle, Jacqueline A. Hannam

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 8, Pp 1409-1421 (2024)

Abstract Cardiopulmonary bypass (CPB) can alter pharmacokinetic (PK) parameters and the drug may adsorb to the CPB device, altering exposure. Cefazolin is a beta‐lactam antibiotic used for antimicrobial prophylaxis during cardiac surgery supported

Externí odkaz: https://doaj.org/article/63766ef6483f42269ec7f7107a9503ee

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Akademický článek

Consistent methods for fat‐free mass, creatinine clearance, and glomerular filtration rate to describe renal function from neonates to adults

Autor: Conor J. O'Hanlon, Nick Holford, Anita Sumpter, Hesham S. Al‐Sallami

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 3, Pp 401-412 (2023)

Abstract Quantifying the effect of kidney disease on glomerular filtration rate (GFR) is important when describing variability in the clearance of drugs eliminated by the kidney. We aimed to develop a continuous model for renal function (RF) from pre

Externí odkaz: https://doaj.org/article/9deeea5274c6469788251f724cfad0df

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Akademický článek

Habitat Selection and Specialisation of Herring Gulls During the Non-breeding Season

Autor: Nina J. O’Hanlon, Chris B. Thaxter, Niall H. K. Burton, Dave Grant, Nigel A. Clark, Gary D. Clewley, Greg J. Conway, Lee J. Barber, Rona A. R. McGill, Ruedi G. Nager

Publikováno v: Frontiers in Marine Science, Vol 9 (2022)

Understanding both the distribution and habitat use of populations through the annual cycle is vital to understanding how vulnerable species are to environmental change. However, distributions and habitat use can vary among individuals and population

Externí odkaz: https://doaj.org/article/031fb8d8312041f7b9649cf690bad60a

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Akademický článek

Chytridiomycosis Outbreak in a Chilean Giant Frog (Calyptocephalella gayi) Captive Breeding Program: Genomic Characterization and Pathological Findings

Autor: Mario Alvarado-Rybak, Paz Acuña, Alexandra Peñafiel-Ricaurte, Thomas R. Sewell, Simon J. O'Hanlon, Matthew C. Fisher, Andres Valenzuela-Sánchez, Andrew A. Cunningham, Claudio Azat

Publikováno v: Frontiers in Veterinary Science, Vol 8 (2021)

Emerging infectious diseases in wildlife are increasingly associated with animal mortality and species declines, but their source and genetic characterization often remains elusive. Amphibian chytridiomycosis, caused by the fungus Batrachochytrium de

Externí odkaz: https://doaj.org/article/a39fbb9635e24a59ac9aa758e1f4739a

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Akademický článek

Identifying co-endemic areas for major filarial infections in sub-Saharan Africa: seeking synergies and preventing severe adverse events during mass drug administration campaigns

Autor: Jorge Cano, Maria-Gloria Basáñez, Simon J. O’Hanlon, Afework H. Tekle, Samuel Wanji, Honorat G. Zouré, Maria P. Rebollo, Rachel L. Pullan

Publikováno v: Parasites & Vectors, Vol 11, Iss 1, Pp 1-11 (2018)

Abstract Background Onchocerciasis and lymphatic filariasis (LF) are major filarial infections targeted for elimination in most endemic sub-Saharan Africa (SSA) countries by 2020/2025. The current control strategies are built upon community-directed

Externí odkaz: https://doaj.org/article/f05db2660bd24021aac0325429e31dae

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Akademický článek

Feasibility of Using a Luminescence-Based Method to Determine Serum Bactericidal Activity against Neisseria gonorrhoeae

Autor: Fiona Clow, Conor J O’Hanlon, Myron Christodoulides, Fiona J Radcliff

Publikováno v: Vaccines, Vol 7, Iss 4, p 191 (2019)

Development of a vaccine to limit the impact of antibiotic resistant Neisseria gonorrhoeae is now a global priority. Serum bactericidal antibody (SBA) is a possible indicator of protective immunity to N. gonorrhoeae, but conventional assays measure c

Externí odkaz: https://doaj.org/article/e0a96a46339c44059c7b38c1baadf702

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Akademický článek

Model-Based Geostatistical Mapping of the Prevalence of Onchocerca volvulus in West Africa.

Autor: Simon J O'Hanlon, Hannah C Slater, Robert A Cheke, Boakye A Boatin, Luc E Coffeng, Sébastien D S Pion, Michel Boussinesq, Honorat G M Zouré, Wilma A Stolk, María-Gloria Basáñez

Publikováno v: PLoS Neglected Tropical Diseases, Vol 10, Iss 1, p e0004328 (2016)

BACKGROUND:The initial endemicity (pre-control prevalence) of onchocerciasis has been shown to be an important determinant of the feasibility of elimination by mass ivermectin distribution. We present the first geostatistical map of microfilarial pre

Externí odkaz: https://doaj.org/article/19d491ab45454e2d95c242a1b9d919b3

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Akademický článek

Genotypic Diversity Is Associated with Clinical Outcome and Phenotype in Cryptococcal Meningitis across Southern Africa.

Autor: Mathew A Beale, Wilber Sabiiti, Emma J Robertson, Karen M Fuentes-Cabrejo, Simon J O'Hanlon, Joseph N Jarvis, Angela Loyse, Graeme Meintjes, Thomas S Harrison, Robin C May, Matthew C Fisher, Tihana Bicanic

Publikováno v: PLoS Neglected Tropical Diseases, Vol 9, Iss 6, p e0003847 (2015)

Cryptococcal meningitis is a major cause of mortality throughout the developing world, yet little is known about the genetic markers underlying Cryptococcal virulence and patient outcome. We studied a cohort of 230 Cryptococcus neoformans (Cn) isolat

Externí odkaz: https://doaj.org/article/bb591a21a4604aa68a90a1be32b27ee8

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