Zobrazeno 1 - 10
of 29
pro vyhledávání: '"P J, O'Donovan"'
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
A new diagnosis of type 1 diabetes (T1D) may be accompanied by numerous lifelong financial, emotional, and physical challenges, thus advancements in therapies that can delay the onset of clinical disease are crucial. T1D is an autoimmune condition in
Externí odkaz:
https://doaj.org/article/d629ba11f459462fb968f0d028ac2baf
Autor:
Philip W. Brownjohn, Azedine Zoufir, Daniel J. O’Donovan, Saatviga Sudhahar, Alexander Syme, Rosemary Huckvale, John R. Porter, Hester Bange, Jane Brennan, Neil T. Thompson
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Autosomal dominant polycystic kidney disease (ADPKD) is a rare genetic disorder characterised by numerous renal cysts, the progressive expansion of which can impact kidney function and lead eventually to renal failure. Tolvaptan is the only disease-m
Externí odkaz:
https://doaj.org/article/f0f14632f7bf4fa7be3e8e7254e4258c
Autor:
Lauren N. Miterko, Joshua J. White, Tao Lin, Amanda M. Brown, Kevin J. O’Donovan, Roy V. Sillitoe
Publikováno v:
Neural Development, Vol 14, Iss 1, Pp 1-22 (2019)
Abstract Background Purkinje cells play a central role in establishing the cerebellar circuit. Accordingly, disrupting Purkinje cell development impairs cerebellar morphogenesis and motor function. In the Car8 wdl mouse model of hereditary ataxia, se
Externí odkaz:
https://doaj.org/article/6b974dde990a442abbe65e48ccf2eeb5
Autor:
Megan N. Houston, Kevin J. O'Donovan, Jesse R. Trump, Rachel M. Brodeur, Gerald T. McGinty, J. Kenneth Wickiser, Christopher J. D'Lauro, Jonathan C. Jackson, Steven J. Svoboda, Adam J. Susmarski, Steven P. Broglio, Thomas W. McAllister, Michael A. McCrea, Paul Pasquina, Kenneth L. Cameron
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Despite the significant impact that concussion has on military service members, significant gaps remain in our understanding of the optimal diagnostic, management, and return to activity/duty criteria to mitigate the consequences of concussion. In re
Externí odkaz:
https://doaj.org/article/fce042945aee484c8325fb108eda25e5
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
The most evident phenotype of degenerative motoneuron disease is the loss of motor function which accompanies motoneuron death. In both amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA), it is now clear that dysfunction is not res
Externí odkaz:
https://doaj.org/article/f08f3c648cc3415fa3b91af978d33aae
Autor:
D.P. Berry, A. O’Brien, J. O’Donovan, N. McHugh, E. Wall, S. Randles, K. McDermott, R.E. O’Connor, M.A. Patil, J. Ho, A. Kennedy, N. Byrne, D.C. Purfield
Publikováno v:
Animal, Vol 12, Iss 12, Pp 2462-2469 (2018)
Early detection of karyotype abnormalities, including aneuploidy, could aid producers in identifying animals which, for example, would not be suitable candidate parents. Genome-wide genetic marker data in the form of single nucleotide polymorphisms (
Externí odkaz:
https://doaj.org/article/030116ff6ccf418f94a85067f2674972
Publikováno v:
PLoS Biology, Vol 17, Iss 9, p e3000447 (2019)
In the mouse spinal cord, V1 interneurons are a heterogeneous population of inhibitory spinal interneurons that have been implicated in regulating the frequency of the locomotor rhythm and in organizing flexor and extensor alternation. By introducing
Externí odkaz:
https://doaj.org/article/1f3984184d3543eb88847c4b95edda66
Autor:
S.J., Leo J. O’Donovan
Publikováno v:
Journal of Jesuit Studies; January 2024, Vol. 11 Issue: 2 p357-360, 4p
Publikováno v:
eLife, Vol 6 (2017)
Motoneurons are traditionally viewed as the output of the spinal cord that do not influence locomotor rhythmogenesis. We assessed the role of motoneuron firing during ongoing locomotor-like activity in neonatal mice expressing archaerhopsin-3 (Arch),
Externí odkaz:
https://doaj.org/article/31316c11901a47438854f42db0fa15ae
Publikováno v:
eLife, Vol 6 (2017)
Physiological responses to nociceptive stimuli are initiated within tens of milliseconds, but the corresponding sub-second behavioral responses have not been adequately explored in awake, unrestrained animals. A detailed understanding of these respon
Externí odkaz:
https://doaj.org/article/0cbd03e19f5845b095e7c9283316b83f