Zobrazeno 1 - 10
of 144
pro vyhledávání: '"P J, Lyons"'
Autor:
Alan J. Keane, Clara Sanz-Nogués, Dulan Jayasooriya, Michael Creane, Xizhe Chen, Caomhán J. Lyons, Isha Sikri, Katarzyna Goljanek-Whysall, Timothy O’Brien
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Chronic limb-threatening ischaemia (CLTI), the most severe manifestation of peripheral arterial disease (PAD), is associated with a poor prognosis and high amputation rates. Despite novel therapeutic approaches being investigated, no signifi
Externí odkaz:
https://doaj.org/article/166524dc20094da3b7a8d6a8fafaef6e
Autor:
Andrzej S. Januszewski, Hayden K. Young, Kwok‐Leung Ong, Liping Li, Rachel L. O’Connell, Timothy J. Lyons, Clare Kelly, Dessi P. Zaharieva, David R. Sullivan, Russell S. Scott, Anthony C. Keech, Alicia J. Jenkins, the FIELD Study Investigators
Publikováno v:
Journal of Diabetes Investigation, Vol 15, Iss 11, Pp 1663-1668 (2024)
ABSTRACT Aims/Hypothesis In diabetes haptoglobin (Hp) 2 vs Hp 1 allelic product is associated with cardiac and renal complications. Few studies report both Hp phenotype and Hp levels. In a Fenofibrate Intervention and Event Lowering in Diabetes (FIEL
Externí odkaz:
https://doaj.org/article/27ffb399c2964632af611c4bfd112dcd
Autor:
Yi Lei, Qiangyun Liu, Binggui Chen, Fangfang Wu, Yiming Li, Xue Dong, Nina Ma, Ziru Wu, Yanfang Zhu, Lu Wang, Yuxin Fu, Yuming Liu, Yinting Song, Mei Du, Heng Zhang, Jidong Zhu, Timothy J. Lyons, Ting Wang, Junhao Hu, Heping Xu, Mei Chen, Hua Yan, Xiaohong Wang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)
Abstract Metabolic disorder significantly contributes to diabetic vascular complications, including diabetic retinopathy, the leading cause of blindness in the working-age population. However, the molecular mechanisms by which disturbed metabolic hom
Externí odkaz:
https://doaj.org/article/87d67773b7684dc4b79110b484e81aa2
Autor:
Shahzad Ahmad, Mohammad Aslam Imtiaz, Aniket Mishra, Ruiqi Wang, Marisol Herrera-Rivero, Joshua C. Bis, Myriam Fornage, Gennady Roshchupkin, Edith Hofer, Mark Logue, W. T. Longstreth, Rui Xia, Vincent Bouteloup, Thomas Mosley, Lenore J. Launer, Michael Khalil, Jens Kuhle, Robert A. Rissman, Genevieve Chene, Carole Dufouil, Luc Djoussé, Michael J. Lyons, Kenneth J. Mukamal, William S. Kremen, Carol E. Franz, Reinhold Schmidt, Stephanie Debette, Monique M. B. Breteler, Klaus Berger, Qiong Yang, Sudha Seshadri, N. Ahmad Aziz, Mohsen Ghanbari, M. Arfan Ikram
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract Neurofilament light chain (NfL) levels in circulation have been established as a sensitive biomarker of neuro-axonal damage across a range of neurodegenerative disorders. Elucidation of the genetic architecture of blood NfL levels could prov
Externí odkaz:
https://doaj.org/article/14e2c47872a446f281d0e204198d3b52
Autor:
Michael C. Robertson, Maria Chang Swartz, Karen M. Basen-Engquist, Yisheng Li, Kristofer Jennings, Debbe Thompson, Tom Baranowski, Elena Volpi, Elizabeth J. Lyons
Publikováno v:
BMC Public Health, Vol 24, Iss 1, Pp 1-15 (2024)
Abstract Background Older adult women often do not engage in sufficient physical activity (PA) and can encounter biological changes that exacerbate the negative effects of inadequate activity. Wearable activity monitors can facilitate PA initiation,
Externí odkaz:
https://doaj.org/article/e69da11084694703b2b5e0cb7e461d03
Autor:
Sissy Bassani, Jacqueline Chrast, Giovanna Ambrosini, Norine Voisin, Frédéric Schütz, Alfredo Brusco, Fabio Sirchia, Lydia Turban, Susanna Schubert, Rami Abou Jamra, Jan-Ulrich Schlump, Desiree DeMille, Pinar Bayrak-Toydemir, Gary Rex Nelson, Kristen Nicole Wong, Laura Duncan, Mackenzie Mosera, Christian Gilissen, Lisenka E. L. M. Vissers, Rolph Pfundt, Rogier Kersseboom, Hilde Yttervik, Geir Åsmund Myge Hansen, Marie Falkenberg Smeland, Kameryn M. Butler, Michael J. Lyons, Claudia M. B. Carvalho, Chaofan Zhang, James R. Lupski, Lorraine Potocki, Leticia Flores-Gallegos, Rodrigo Morales-Toquero, Florence Petit, Binnaz Yalcin, Annabelle Tuttle, Houda Zghal Elloumi, Lane McCormick, Mary Kukolich, Oliver Klaas, Judit Horvath, Marcello Scala, Michele Iacomino, Francesca Operto, Federico Zara, Karin Writzl, Aleš Maver, Maria K. Haanpää, Pia Pohjola, Harri Arikka, Anneke J. A. Kievit, Camilla Calandrini, Christian Iseli, Nicolas Guex, Alexandre Reymond
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-18 (2024)
Abstract Background We previously described the KINSSHIP syndrome, an autosomal dominant disorder associated with intellectual disability (ID), mesomelic dysplasia and horseshoe kidney, caused by de novo variants in the degron of AFF3. Mouse knock-in
Externí odkaz:
https://doaj.org/article/0358fc56f6054b188a138c71c996e968
Autor:
Rongxiang Tang, Erik Buchholz, Anders M. Dale, Robert A. Rissman, Christine Fennema-Notestine, Nathan A. Gillespie, Donald J Hagler, Michael J. Lyons, Michael C. Neale, Matthew S. Panizzon, Olivia K. Puckett, Chandra A. Reynolds, Carol E. Franz, William S. Kremen, Jeremy A. Elman
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-11 (2024)
Abstract Background Plasma neurofilament light chain (NfL) is a promising biomarker of neurodegeneration with potential clinical utility in monitoring the progression of neurodegenerative diseases. However, the cross-sectional associations of plasma
Externí odkaz:
https://doaj.org/article/76973dd443624b90a1ebf2477b1724ec
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract Endothelial colony-forming cells (ECFCs) are progenitors of endothelial cells with significant proliferative and angiogenic ability. ECFCs are a promising treatment option for various diseases, such as ischemic heart disease and peripheral a
Externí odkaz:
https://doaj.org/article/c3d3f2cdd2be4a06a05aff43601d916a
Autor:
Aidan Anderson, Nada Alfahad, Dulani Wimalachandra, Kaouthar Bouzinab, Paula Rudzinska, Heather Wood, Isabel Fazey, Heping Xu, Timothy J. Lyons, Nicholas M. Barnes, Parth Narendran, Janet M. Lord, Saaeha Rauz, Ian G. Ganley, Tim M. Curtis, Graham R. Wallace, Jose R. Hombrebueno
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The recovery of mitochondrial quality control (MQC) may bring innovative solutions for neuroprotection, while imposing a significant challenge given the need of holistic approaches to restore mitochondrial dynamics (fusion/fission) and turno
Externí odkaz:
https://doaj.org/article/49bb462680fd472a9c0826d8dc86da53
Autor:
Brian Walitt, Komudi Singh, Samuel R. LaMunion, Mark Hallett, Steve Jacobson, Kong Chen, Yoshimi Enose-Akahata, Richard Apps, Jennifer J. Barb, Patrick Bedard, Robert J. Brychta, Ashura Williams Buckley, Peter D. Burbelo, Brice Calco, Brianna Cathay, Li Chen, Snigdha Chigurupati, Jinguo Chen, Foo Cheung, Lisa M. K. Chin, Benjamin W. Coleman, Amber B. Courville, Madeleine S. Deming, Bart Drinkard, Li Rebekah Feng, Luigi Ferrucci, Scott A. Gabel, Angelique Gavin, David S. Goldstein, Shahin Hassanzadeh, Sean C. Horan, Silvina G. Horovitz, Kory R. Johnson, Anita Jones Govan, Kristine M. Knutson, Joy D. Kreskow, Mark Levin, Jonathan J. Lyons, Nicholas Madian, Nasir Malik, Andrew L. Mammen, John A. McCulloch, Patrick M. McGurrin, Joshua D. Milner, Ruin Moaddel, Geoffrey A. Mueller, Amrita Mukherjee, Sandra Muñoz-Braceras, Gina Norato, Katherine Pak, Iago Pinal-Fernandez, Traian Popa, Lauren B. Reoma, Michael N. Sack, Farinaz Safavi, Leorey N. Saligan, Brian A. Sellers, Stephen Sinclair, Bryan Smith, Joseph Snow, Stacey Solin, Barbara J. Stussman, Giorgio Trinchieri, Sara A. Turner, C. Stephenie Vetter, Felipe Vial, Carlotta Vizioli, Ashley Williams, Shanna B. Yang, Center for Human Immunology, Autoimmunity, and Inflammation (CHI) Consortium, Avindra Nath
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-29 (2024)
Abstract Post-infectious myalgic encephalomyelitis/chronic fatigue syndrome (PI-ME/CFS) is a disabling disorder, yet the clinical phenotype is poorly defined, the pathophysiology is unknown, and no disease-modifying treatments are available. We used
Externí odkaz:
https://doaj.org/article/a14b918b7de649e6975c4ac14fdd7aa8