Zobrazeno 1 - 10
of 43
pro vyhledávání: '"P J, HODES"'
Publikováno v:
PLoS ONE, Vol 19, Iss 12, p e0312864 (2024)
Mice deficient in the ataxia telangiectasia mutated (ATM) kinase have impaired responses to genotoxic and oxidative stressors, predisposing them to develop thymic T-cell lymphoblastic lymphomas (T-LBL) resembling human T-cell acute lymphoblastic leuk
Externí odkaz:
https://doaj.org/article/8f00f2e247a34f24ac6d3e204cdfa22f
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
B7-CD28 co-stimulation is important for T cell activation and clonal expansion in the periphery. Here the authors show that, in mouse thymus, B7-CD28 differentially controls thymocyte clonal deletion and Treg induction, with distinct CD28 signaling d
Externí odkaz:
https://doaj.org/article/2b526663f7e1461c91c46d55318b2189
Autor:
Marian J E Mourits, Barbara C van Munster, Gyorgy B Halmos, Gera A Welker, Hester J van der Zaag-Loonen, Emoke Racz, Famke M van Erkel, Myrthe J Pet, Elles HM Bossink, Cathy F M van de Graaf, Marije T J Hodes, Sonja N van Ogtrop, Barbara van Leeuwen, Anna K L Reyners
Publikováno v:
BMJ Open, Vol 12, Iss 3 (2022)
Objective To evaluate the perceived quality of follow-up telephone consultations (TCs) from the perspective of patients and healthcare professionals (HCPs) of multiple medical disciplines during the COVID-19 pandemic.Design A qualitative study using
Externí odkaz:
https://doaj.org/article/ccfa6a0e49c64ce19296018f2ffc64b0
Autor:
Ana Lustig, Hans B. Liu, E. Jeffrey Metter, Yang An, Melissa A. Swaby, Palchamy Elango, Luigi Ferrucci, Richard J. Hodes, Nan-ping Weng
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
A number of biological parameters have been cited as hallmarks of immune aging. However, it is not clear whether these multiple biological changes are the result of common underlying aging processes and follow correlated trajectories, or whether the
Externí odkaz:
https://doaj.org/article/6c3ac904bf1e4849a73ca0c2daf17584
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e62188 (2013)
Generation and resolution of DNA double-strand breaks is required to assemble antigen-specific receptors from the genes encoding V, D, and J gene segments during recombination. The present report investigates the requirement for ataxia telangiectasia
Externí odkaz:
https://doaj.org/article/c7d208ce07ad44aab3dc31af1d57855e
Autor:
Y Jeffrey Chiang, Michael J Difilippantonio, Lino Tessarollo, Herbert C Morse, Richard J Hodes
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49305 (2012)
p53 is a tumor suppressor gene mutated in >50% of human cancers, while p53 deficiency in mice results in cancers and accelerated mortality. Thymic T cell lymphoma is the most common malignancy in p53-deficient mice, making it difficult to study the r
Externí odkaz:
https://doaj.org/article/c7738db43856491da3e0532b56fe3dcf
Autor:
Jeffrey Chiang, Richard J Hodes
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18542 (2011)
Extensive studies of pre-TCR- and TCR-dependent signaling have led to characterization of a pathway deemed essential for efficient T cell development, and comprised of a cascade of sequential events involving phosphorylation of Lck and ZAP-70, follow
Externí odkaz:
https://doaj.org/article/18dcf4a5077f4beb8345324b9651308e
Autor:
Karen S Hathcock, Lila Farrington, Irina Ivanova, Ferenc Livak, Roza Selimyan, Ranjan Sen, Joy Williams, Xuguang Tai, Richard J Hodes
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20639 (2011)
T cell development occurs in the thymus and is critically dependent on productive TCRβ rearrangement and pre-TCR expression in DN3 cells. The requirement for pre-TCR expression results in the arrest of thymocytes at the DN3 stage (β checkpoint), wh
Externí odkaz:
https://doaj.org/article/249b9fedd00d485e85240b65e0a4f66b
Autor:
Y Jeffrey Chiang, Susan J Hsiao, Dena Yver, Samuel W Cushman, Lino Tessarollo, Susan Smith, Richard J Hodes
Publikováno v:
PLoS ONE, Vol 3, Iss 7, p e2639 (2008)
Tankyrases are proteins with poly(ADP-ribose) polymerase activity. Human tankyrases post-translationally modify multiple proteins involved in processes including maintenance of telomere length, sister telomere association, and trafficking of glut4-co
Externí odkaz:
https://doaj.org/article/270737a246404ee5b2b4592fe4e8bc65
Autor:
Alexei A Sharov, Yulan Piao, Ryo Matoba, Dawood B Dudekula, Yong Qian, Vincent VanBuren, Geppino Falco, Patrick R Martin, Carole A Stagg, Uwem C Bassey, Yuxia Wang, Mark G Carter, Toshio Hamatani, Kazuhiro Aiba, Hidenori Akutsu, Lioudmila Sharova, Tetsuya S Tanaka, Wendy L Kimber, Toshiyuki Yoshikawa, Saied A Jaradat, Serafino Pantano, Ramaiah Nagaraja, Kenneth R Boheler, Dennis Taub, Richard J Hodes, Dan L Longo, David Schlessinger, Jonathan Keller, Emily Klotz, Garnett Kelsoe, Akihiro Umezawa, Angelo L Vescovi, Janet Rossant, Tilo Kunath, Brigid L M Hogan, Anna Curci, Michele D'Urso, Janet Kelso, Winston Hide, Minoru S H Ko
Publikováno v:
PLoS Biology, Vol 1, Iss 3, p E74 (2003)
Understanding and harnessing cellular potency are fundamental in biology and are also critical to the future therapeutic use of stem cells. Transcriptome analysis of these pluripotent cells is a first step towards such goals. Starting with sources th
Externí odkaz:
https://doaj.org/article/1708d315f6714b659334ba91f551e95e