Zobrazeno 1 - 10
of 15
pro vyhledávání: '"P J, Guelen"'
Autor:
T, Vink-van Wijngaarden, M E, Blom-Ross, D, Lansdorp, D M, Goedhart, J, Eelhart, P J, Guelen, D, de Vos
Publikováno v:
International journal of clinical pharmacology and therapeutics. 36(9)
The study was undertaken to compare the efficacy and safety of beclomethasone dipropionate inhalation powder inhaled by Rotahaler (Becotide Rotacaps, Glaxo Wellcome) and by Cyclohaler (Beclomethasone Cyclocaps, Pharmachemie). Both the Cyclohaler and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::18412730de6052299655e8bf7ba9b3dc
https://pubmed.ncbi.nlm.nih.gov/9760014
https://pubmed.ncbi.nlm.nih.gov/9760014
Publikováno v:
International journal of clinical pharmacology, therapy, and toxicology. 31(12)
We studied the effects of cimetidine, ranitidine and famotidine on the kinetics of naproxen. The mean t1/2 beta of naproxen in 6 subjects was 25.7 +/- 5.4 h (range 16 to 36). Naproxen acyl glucuronide accounts for 50.9 +/- 6.9% of the dose, its isome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dd4134602d1dbd9d0a656fbf2aa46a73
https://pubmed.ncbi.nlm.nih.gov/8314361
https://pubmed.ncbi.nlm.nih.gov/8314361
Autor:
S K, Bulstra, R, Kuijer, W A, Buurman, E, Terwindt-Rouwenhorst, P J, Guelen, A J, van der Linden
Publikováno v:
Clinical orthopaedics and related research. (277)
The effect of piroxicam on the metabolism of healthy and osteoarthrotic (OA) chondrocytes was studied in vitro. The chondrocytes were obtained from five healthy, five moderately OA, and four severely OA hips or knees. The chondrocytes were cultured i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bf1d6e804b638b7ebfb7aa6b66db0a69
https://pubmed.ncbi.nlm.nih.gov/1555353
https://pubmed.ncbi.nlm.nih.gov/1555353
Publikováno v:
Acta anaesthesiologica Belgica. 42(3)
This study investigated the pharmacokinetics of midazolam and its main metabolite, 1-hydroxymethylmidazolam glucoronide, during long-term i.v. infusion in 39 mechanically ventilated ICU patients of whom 6 were in acute renal failure (ARF). The mean i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9420ba118863d9c946b6803f892277f3
https://pubmed.ncbi.nlm.nih.gov/1767626
https://pubmed.ncbi.nlm.nih.gov/1767626
Publikováno v:
International journal of clinical pharmacology, therapy, and toxicology. 28(7)
Diclofenac 100 mg suppository is well absorbed from the gastrointestinal tract of six human volunteers. Plasma concentrations of 4'-hydroxydiclofenac and diclofenac could be measured; the concentrations of the three other metabolites were below the d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6794ccb5976d47118a80172ed04bbf28
https://pubmed.ncbi.nlm.nih.gov/2387653
https://pubmed.ncbi.nlm.nih.gov/2387653
Publikováno v:
The American journal of medicine. 87(6C)
In a three-week study, the metabolism of the bronchodilator theophylline and its major metabolites formed by C-8 oxidation (1,3-dimethyluric acid) and N-demethylation (3-methylxanthine and 1-methyluric acid) was investigated in two healthy volunteers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::58d202327c98bce6a697139649aa7fb9
https://pubmed.ncbi.nlm.nih.gov/2603893
https://pubmed.ncbi.nlm.nih.gov/2603893
Publikováno v:
International journal of clinical pharmacology, therapy, and toxicology. 26(4)
After a rectal dose of 500 mg in a suppository, naproxen is 6-O-demethylated (20%) and glucuronidated (40%), the metabolites are subsequently excreted renally. The elimination half-life is 15.2 +/- 2.6 h. Ten out of 22 subjects show biphasic eliminat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c6305d156f082b4290daf490331bf28d
https://pubmed.ncbi.nlm.nih.gov/3403096
https://pubmed.ncbi.nlm.nih.gov/3403096
Publikováno v:
Methods and findings in experimental and clinical pharmacology. 9(10)
Tamoxifen and N-desmethyltamoxifen plasma concentrations were determined in a single dose cross-over study with Tamoplex and Nolvadex at the dose height of 40 mg in 18 healthy male volunteers with a wash-out period of at least 140 days. ANOVA, power
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8b05222521843b1e7caea6f10888562d
https://pubmed.ncbi.nlm.nih.gov/3441162
https://pubmed.ncbi.nlm.nih.gov/3441162
Publikováno v:
Aktuelle Probleme in Chirurgie und Orthopadie. 31
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5db1c3a724d59eed7c0af6dcc43b54de
https://pubmed.ncbi.nlm.nih.gov/2888363
https://pubmed.ncbi.nlm.nih.gov/2888363
Publikováno v:
Methods and findings in experimental and clinical pharmacology. 8(8)
Tamoxifen and N-desmethyltamoxifen plasma concentrations were found to be similar after a first single dose and during two months therapy with Tamoplex or Nolvadex in groups of 6 and 8 patients, respectively. Single dose absorption results in 10 heal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9492af29a4e286d3844574bcffdb224f
https://pubmed.ncbi.nlm.nih.gov/3747644
https://pubmed.ncbi.nlm.nih.gov/3747644