Zobrazeno 1 - 10
of 22
pro vyhledávání: '"P J, Giardina"'
Publikováno v:
Journal of Extracellular Vesicles, Vol 3, Iss 0, Pp 1-11 (2014)
Background: Protein secretion is a fundamental process in all living cells. Gluconeogenic enzymes are secreted when Saccharomyces cerevisiae are grown in media containing low glucose. However, when cells are transferred to media containing high gluco
Externí odkaz:
https://doaj.org/article/e365ba42eace4a4082cee32c7cf66bd4
Autor:
Robert W. Grady, Renzo Galanello, Rachel E. Randolph, Dorothy A. Kleinert, Carlo Dessi, Patricia J. Giardina
Publikováno v:
Haematologica, Vol 98, Iss 1 (2013)
Patients with β-thalassemia require iron chelation therapy to protect against progressive iron overload and non-transferrin-bound iron. Some patients fail to respond adequately to deferoxamine and deferasirox monotherapy while others have side effec
Externí odkaz:
https://doaj.org/article/b74d058b039c474ba9fc9bedc9e56537
Autor:
Nancy S Green, Katherine L Ender, Farzana Pashankar, Catherine Driscoll, Patricia J Giardina, Craig A Mullen, Lorraine N Clark, Deepa Manwani, Jennifer Crotty, Sergey Kisselev, Kathleen A Neville, Carolyn Hoppe, Sandra Barral
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e55709 (2013)
Fetal hemoglobin level is a heritable complex trait that strongly correlates swith the clinical severity of sickle cell disease. Only few genetic loci have been identified as robustly associated with fetal hemoglobin in patients with sickle cell dise
Externí odkaz:
https://doaj.org/article/b92ea4c772dc4035bd0462f3b0f400f6
Autor:
Laura Breda, Carla Casu, Sara Gardenghi, Nicoletta Bianchi, Luca Cartegni, Mohandas Narla, Karina Yazdanbakhsh, Marco Musso, Deepa Manwani, Jane Little, Lawrence B Gardner, Dorothy A Kleinert, Eugenia Prus, Eitan Fibach, Robert W Grady, Patricia J Giardina, Roberto Gambari, Stefano Rivella
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e32345 (2012)
Preclinical and clinical studies demonstrate the feasibility of treating β-thalassemia and Sickle Cell Disease (SCD) by lentiviral-mediated transfer of the human β-globin gene. However, previous studies have not addressed whether the ability of len
Externí odkaz:
https://doaj.org/article/472254d68557495b9619e90809e22289
Autor:
Paul Harmatz, Maureen M. Jonas, Janet L. Kwiatkowski, Elizabeth C. Wright, Roland Fischer, Elliott Vichinsky, Patricia J. Giardina, Ellis J. Neufeld, John Porter, Nancy Olivieri
Publikováno v:
Haematologica, Vol 93, Iss 8 (2008)
Antiviral treatment of hepatitis C virus in thalassemia has raised concerns of ribavirin-induced hemolysis and increased iron loading. This study examined the change in liver iron concentration, transfusion requirement, virological response, and iron
Externí odkaz:
https://doaj.org/article/107e5d20a0ad40a488f863f632b915e6
Autor:
Patrick B. Walter, Eric A. Macklin, John Porter, Patricia Evans, Janet L. Kwiatkowski, Ellis J. Neufeld, Thomas Coates, Patricia J. Giardina, Elliott Vichinsky, Nancy Olivieri, Daniele Alberti, Jaymes Holland, Paul Harmatz
Publikováno v:
Haematologica, Vol 93, Iss 6 (2008)
Background We assessed whether oxidant-stress and inflammation in β-thalassemia could be controlled by the novel oral iron chelator deferasirox as effectively as by deferoxamine.Design and Methods Forty-nine subjects were enrolled from seven sites a
Externí odkaz:
https://doaj.org/article/041e9a68c80445619fe8ac633d561d52
Publikováno v:
Immunohematology. 26(3)
The DAT is performed for the detection of antibody or complement on the surface of RBCs. Our institution previously performed DATs on all chronically transfused thalassemia patients before each transfusion episode to detect early alloimmunization. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::279359bc69062de6158cdffb53982fd9
https://pubmed.ncbi.nlm.nih.gov/21214294
https://pubmed.ncbi.nlm.nih.gov/21214294
Autor:
A, Sobota, R, Yamashita, Y, Xu, F, Trachtenberg, P, Kohlbry, D A, Kleinert, P J, Giardina, J L, Kwiatkowski, D, Foote, V, Thayalasuthan, J B, Porter, A A, Thompson, L, Schilling, C T, Quinn, E J, Neufeld, Felicia, Trachtenberg
Publikováno v:
American journal of hematology. 86(1)
Thalassemia is a chronic, inherited blood disorder, which, in its most severe form, causes life-threatening anemia. Advances in treatment have led to increased life expectancy however the need for chronic blood transfusions and chelation therapy rema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3a3f51fe9dda8ef173bec26d138214d
https://pubmed.ncbi.nlm.nih.gov/21061309
https://pubmed.ncbi.nlm.nih.gov/21061309
Autor:
P. J. Giardina, M. W. Hilgartner
Publikováno v:
Pediatrics In Review. 13:55-62
Many advances in the understanding and management of the thalassmia syndromes have been made during the past several years. Our knowledge of normal globin gene function and of the consequences of specific mutations has been advanced by identification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::153cce3c083456dda13e3ca347b28bcf
https://doi.org/10.1542/pir.13.2.55
https://doi.org/10.1542/pir.13.2.55
Publikováno v:
American journal of medical genetics. 62(1)
Thalassemias occur in individuals of all ethnic backgrounds and are among the most common genetic diseases worldwide. The diagnosis of thalassemia can easily be part of primary medical practice. Here we outline a practical approach to the detection o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::54cd629326dc9a2ddbc20af93a9e05f0
https://pubmed.ncbi.nlm.nih.gov/8779321
https://pubmed.ncbi.nlm.nih.gov/8779321