Výsledky vyhledávání - "P J, Giardina"

Akademický článek

The endocytosis gene END3 is essential for the glucose-induced rapid decline of small vesicles in the extracellular fraction in Saccharomyces cerevisiae

Autor: Bennett J. Giardina, Kathryn Stein, Hui-Ling Chiang

Publikováno v: Journal of Extracellular Vesicles, Vol 3, Iss 0, Pp 1-11 (2014)

Background: Protein secretion is a fundamental process in all living cells. Gluconeogenic enzymes are secreted when Saccharomyces cerevisiae are grown in media containing low glucose. However, when cells are transferred to media containing high gluco

Externí odkaz: https://doaj.org/article/e365ba42eace4a4082cee32c7cf66bd4

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Akademický článek

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Akademický článek

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Akademický článek

Toward optimizing the use of deferasirox: potential benefits of combined use with deferoxamine

Autor: Robert W. Grady, Renzo Galanello, Rachel E. Randolph, Dorothy A. Kleinert, Carlo Dessi, Patricia J. Giardina

Publikováno v: Haematologica, Vol 98, Iss 1 (2013)

Patients with β-thalassemia require iron chelation therapy to protect against progressive iron overload and non-transferrin-bound iron. Some patients fail to respond adequately to deferoxamine and deferasirox monotherapy while others have side effec

Externí odkaz: https://doaj.org/article/b74d058b039c474ba9fc9bedc9e56537

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Akademický článek

Candidate sequence variants and fetal hemoglobin in children with sickle cell disease treated with hydroxyurea.

Autor: Nancy S Green, Katherine L Ender, Farzana Pashankar, Catherine Driscoll, Patricia J Giardina, Craig A Mullen, Lorraine N Clark, Deepa Manwani, Jennifer Crotty, Sergey Kisselev, Kathleen A Neville, Carolyn Hoppe, Sandra Barral

Publikováno v: PLoS ONE, Vol 8, Iss 2, p e55709 (2013)

Fetal hemoglobin level is a heritable complex trait that strongly correlates swith the clinical severity of sickle cell disease. Only few genetic loci have been identified as robustly associated with fetal hemoglobin in patients with sickle cell dise

Externí odkaz: https://doaj.org/article/b92ea4c772dc4035bd0462f3b0f400f6

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Akademický článek

Therapeutic hemoglobin levels after gene transfer in β-thalassemia mice and in hematopoietic cells of β-thalassemia and sickle cells disease patients.

Autor: Laura Breda, Carla Casu, Sara Gardenghi, Nicoletta Bianchi, Luca Cartegni, Mohandas Narla, Karina Yazdanbakhsh, Marco Musso, Deepa Manwani, Jane Little, Lawrence B Gardner, Dorothy A Kleinert, Eugenia Prus, Eitan Fibach, Robert W Grady, Patricia J Giardina, Roberto Gambari, Stefano Rivella

Publikováno v: PLoS ONE, Vol 7, Iss 3, p e32345 (2012)

Preclinical and clinical studies demonstrate the feasibility of treating β-thalassemia and Sickle Cell Disease (SCD) by lentiviral-mediated transfer of the human β-globin gene. However, previous studies have not addressed whether the ability of len

Externí odkaz: https://doaj.org/article/472254d68557495b9619e90809e22289

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Akademický článek

Safety and efficacy of pegylated interferon α-2a and ribavirin for the treatment of hepatitis C in patients with thalassemia

Autor: Paul Harmatz, Maureen M. Jonas, Janet L. Kwiatkowski, Elizabeth C. Wright, Roland Fischer, Elliott Vichinsky, Patricia J. Giardina, Ellis J. Neufeld, John Porter, Nancy Olivieri

Publikováno v: Haematologica, Vol 93, Iss 8 (2008)

Antiviral treatment of hepatitis C virus in thalassemia has raised concerns of ribavirin-induced hemolysis and increased iron loading. This study examined the change in liver iron concentration, transfusion requirement, virological response, and iron

Externí odkaz: https://doaj.org/article/107e5d20a0ad40a488f863f632b915e6

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Akademický článek

Inflammation and oxidant-stress in β-thalassemia patients treated with iron chelators deferasirox (ICL670) or deferoxamine: an ancillary study of the Novartis CICL670A0107 trial

Autor: Patrick B. Walter, Eric A. Macklin, John Porter, Patricia Evans, Janet L. Kwiatkowski, Ellis J. Neufeld, Thomas Coates, Patricia J. Giardina, Elliott Vichinsky, Nancy Olivieri, Daniele Alberti, Jaymes Holland, Paul Harmatz

Publikováno v: Haematologica, Vol 93, Iss 6 (2008)

Background We assessed whether oxidant-stress and inflammation in β-thalassemia could be controlled by the novel oral iron chelator deferasirox as effectively as by deferoxamine.Design and Methods Forty-nine subjects were enrolled from seven sites a

Externí odkaz: https://doaj.org/article/041e9a68c80445619fe8ac633d561d52

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Akademický článek

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The significance of a positive DAT in thalassemia patients

Autor: S A, Arinsburg, D L, Skerrett, D, Kleinert, P J, Giardina, M M, Cushing

Publikováno v: Immunohematology. 26(3)

The DAT is performed for the detection of antibody or complement on the surface of RBCs. Our institution previously performed DATs on all chronically transfused thalassemia patients before each transfusion episode to detect early alloimmunization. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::279359bc69062de6158cdffb53982fd9
https://pubmed.ncbi.nlm.nih.gov/21214294

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