Zobrazeno 1 - 10
of 80
pro vyhledávání: '"P J, Fink"'
Autor:
James J. Fink, Nathaniel Delaney-Busch, Ryan Dawes, Evanthia Nanou, Christopher Folts, Karthiayani Harikrishnan, Chris Hempel, Hansini Upadhyay, Trinh Nguyen, Himali Shroff, David Stoppel, Steven J. Ryan, Jane Jacques, Jennifer Grooms, Elizabeth Berry-Kravis, Mark F. Bear, Luis A. Williams, David Gerber, Mark Bunnage, Brinley Furey, Graham T. Dempsey
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)
Abstract Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by hypermethylation of expanded CGG repeats (>200) in the FMR1 gene leading to gene silencing and loss of Fragile X Messenger Ribonucleoprotein (FMRP) expression. FMRP plays im
Externí odkaz:
https://doaj.org/article/4c3520c6a9254e29bb6412e3a3c39efa
Autor:
Jan Henrik Terheyden, David J. Fink, Karl Mercieca, Maximilian W. M. Wintergerst, Frank G. Holz, Robert P. Finger
Publikováno v:
BMC Public Health, Vol 24, Iss 1, Pp 1-9 (2024)
Abstract Background With a rising prevalence of age-related eye diseases, prevention and early diagnosis of these conditions are key goals of public eye health. Disease-related knowledge in the general public supports these goals but there is little
Externí odkaz:
https://doaj.org/article/79df10f293554c51b69469550b80f712
Impact of electron correlations on two-particle charge response in electron- and hole-doped cuprates
Autor:
Abhishek Nag, Luciano Zinni, Jaewon Choi, J. Li, Sijia Tu, A. C. Walters, S. Agrestini, S. M. Hayden, Matías Bejas, Zefeng Lin, H. Yamase, Kui Jin, M. García-Fernández, J. Fink, Andrés Greco, Ke-Jin Zhou
Publikováno v:
Physical Review Research, Vol 6, Iss 4, p 043184 (2024)
Estimating many-body effects that deviate from an independent particle approach has long been a key research interest in condensed matter physics. Layered cuprates are prototypical systems, where electron-electron interactions are found to strongly a
Externí odkaz:
https://doaj.org/article/ca1d33a230cf4f17b9a908f4f759257e
Autor:
Deike J. Omnus, Matthias J. Fink, Aswathy Kallazhi, Maria Xandri Zaragoza, Axel Leppert, Michael Landreh, Kristina Jonas
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract The Lon protease is a highly conserved protein degradation machine that has critical regulatory and protein quality control functions in cells from the three domains of life. Here, we report the discovery of a α-proteobacterial heat shock p
Externí odkaz:
https://doaj.org/article/ea609c52cbc74129b4fbaf0ca4afffde
Autor:
J. J. Lancaster, A. Grijalva, J. Fink, J. Ref, S. Daugherty, S. Whitman, K. Fox, G. Gorman, L. D. Lancaster, R. Avery, T. Acharya, A. McArthur, J. Strom, M. K. Pierce, T. Moukabary, M. Borgstrom, D. Benson, M. Mangiola, A. C. Pandey, M. R. Zile, A. Bradshaw, J. W. Koevary, S. Goldman
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Abstract There are nearly 65 million people with chronic heart failure (CHF) globally, with no treatment directed at the pathologic cause of the disease, the loss of functioning cardiomyocytes. We have an allogeneic cardiac patch comprised of cardiom
Externí odkaz:
https://doaj.org/article/fa79a0230faf4eef89464cb617bedea6
Autor:
Jian-Ping Yang, Rachel Toughiri, Anshu P Gounder, Dan Scheibe, Matt Petrus, Sarah J Fink, Sebastien Vallee, Jon Kenniston, Nikolaos Papaioannou, Steve Langston, Narender R Gavva, Shane R Horman
Publikováno v:
PLoS ONE, Vol 19, Iss 11, p e0307049 (2024)
Induction of fetal hemoglobin (HbF) has been shown to be a viable therapeutic approach to treating sickle cell disease and potentially other β-hemoglobinopathies. To identify targets and target-modulating small molecules that enhance HbF expression,
Externí odkaz:
https://doaj.org/article/8f230a19fa88408da5af340d0b8fa670
Autor:
Jing Li, Xiangdong Zhu, Matt T. Oberdier, Chunpei Lee, Shaoxia Lin, Sarah J. Fink, Cody N. Justice, Kevin Qin, Andrew W. Begeman, Frederick C. Damen, Hajwa Kim, Jiwang Chen, Kejia Cai, Henry R. Halperin, Terry L. Vanden Hoek
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 9 (2023)
Out-of-hospital cardiac arrest is a leading cause of death in the US, with a mortality rate over 90%. Preclinical studies demonstrate that cooling during cardiopulmonary resuscitation (CPR) is highly beneficial, but can be challenging to implement cl
Externí odkaz:
https://doaj.org/article/21e1ed80f0e04c6797c226e941845f6f
Publikováno v:
Advances in Geosciences, Vol 56, Pp 45-56 (2021)
Space heating is a major contributor to the average energy consumption of private households, where the energy standard of a building is a controlling parameter for its heating energy demand. Vertical Ground Source Heat Pumps (vGSHP) present one poss
Externí odkaz:
https://doaj.org/article/156f607cbbb44e95bb65624035a13bd3
Autor:
Amit A. Nagarkar, Samuel E. Root, Michael J. Fink, Alexei S. Ten, Brian J. Cafferty, Douglas S. Richardson, Milan Mrksich, George M. Whitesides
Publikováno v:
ACS Central Science, Vol 7, Iss 10, Pp 1728-1735 (2021)
Externí odkaz:
https://doaj.org/article/ac5296e972a44ad79f5ebb12737812e0
Autor:
Stephanie A. Zlatic, Duc Duong, Kamal K.E. Gadalla, Brenda Murage, Lingyan Ping, Ruth Shah, James J. Fink, Omar Khwaja, Lindsay C. Swanson, Mustafa Sahin, Sruti Rayaprolu, Prateek Kumar, Srikant Rangaraju, Adrian Bird, Daniel Tarquinio, Randall Carpenter, Stuart Cobb, Victor Faundez
Publikováno v:
iScience, Vol 25, Iss 9, Pp 104966- (2022)
Summary: MECP2 loss-of-function mutations cause Rett syndrome, a neurodevelopmental disorder resulting from a disrupted brain transcriptome. How these transcriptional defects are decoded into a disease proteome remains unknown. We studied the proteom
Externí odkaz:
https://doaj.org/article/3dab4af82ddd47d782dbe33e5cc615d1