Zobrazeno 1 - 10
of 22
pro vyhledávání: '"P J, Cheshire"'
Autor:
Beatrice De Lazzari, Massimo Capoccia, Nicholas J. Cheshire, Ulrich P. Rosendahl, Roberto Badagliacca, Claudio De Lazzari
Publikováno v:
Bioengineering, Vol 10, Iss 1, p 60 (2023)
Aortic disease has a significant impact on quality of life. The involvement of the aortic arch requires the preservation of blood supply to the brain during surgery. Deep hypothermic circulatory arrest is an established technique for this purpose, al
Externí odkaz:
https://doaj.org/article/90bbdc9ad8494415ad4db4d1e5f409a1
Autor:
Massimo Capoccia MD, MSc(Eng), Soumik Pal MRCS, Michael Murphy FRCS, Maziar Mireskandari FRCS, Andreas Hoschtitzky MSc, FRCSEd(CTh), Christoph A. Nienaber MD, PhD, FESC, FAHA, Nicholas J. Cheshire MD, FRCS, Ulrich P. Rosendahl MD, FETCS
Publikováno v:
Journal of Investigative Medicine High Impact Case Reports, Vol 9 (2021)
Traditionally, cardiac and vascular surgeons have been treating diseases of the aorta as individual specialists. Neither cardiac nor vascular surgeons have ever considered the aorta as a whole, which can be diseased throughout its length at the same
Externí odkaz:
https://doaj.org/article/4e71fef6087f46b8aae4e2d7827b3eb5
Autor:
Massimo Capoccia, Christoph A. Nienaber, Maziar Mireskandari, Michael Sabetai, Christopher Young, Nicholas J. Cheshire, Ulrich P. Rosendahl
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 8, Iss 8, p 86 (2021)
Total arch replacement remains a very demanding surgical procedure. It can be associated with reasonable long-term outcomes but carries serious perioperative complications. Aortic arch surgery has progressed in recent years to a wider adoption of rep
Externí odkaz:
https://doaj.org/article/c855da80b4ef4add8675490cb640a4d4
Biochemical correlates of mTOR inhibition by the rapamycin ester CCI-779 and tumor growth inhibition
Autor:
L, Dudkin, M B, Dilling, P J, Cheshire, F C, Harwood, M, Hollingshead, S G, Arbuck, R, Travis, E A, Sausville, P J, Houghton
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 7(6)
The rapamycin ester, CCI-779, potently inhibits cell growth in vitro, inhibits tumor growth in vivo, and is currently in Phase I clinical trials. To further understand the relationship between plasma systemic exposure and inhibition of the target Ser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::98f694105e4db7dee6f8ed9880fc1f72
https://pubmed.ncbi.nlm.nih.gov/11410517
https://pubmed.ncbi.nlm.nih.gov/11410517
Autor:
M N, Kirstein, P J, Houghton, P J, Cheshire, L B, Richmond, A K, Smith, S K, Hanna, C F, Stewart
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 7(2)
9-Aminocamptothecin (9-AC) is a topoisomerase I inhibitor with activity against xenografts from childhood solid tumors; however, clinical trials with this compound have been disappointing, resulting in discontinuation of further development. The obje
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::68117bdd129b64d0a56504e62e56d23c
https://pubmed.ncbi.nlm.nih.gov/11234873
https://pubmed.ncbi.nlm.nih.gov/11234873
Autor:
P J, Houghton, C F, Stewart, P J, Cheshire, L B, Richmond, M N, Kirstein, C A, Poquette, M, Tan, H S, Friedman, T P, Brent
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 6(10)
The activity of temozolomide combined with irinotecan (CPT-11) was evaluated against eight independent xenografts (four neuroblastomas, three rhabdomyosarcomas, and one glioblastoma). In all studies, temozolomide was administered p.o. daily for 5 con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5f6ffbf0fba12111a064c367aad4c994
https://pubmed.ncbi.nlm.nih.gov/11051264
https://pubmed.ncbi.nlm.nih.gov/11051264
Autor:
J, Thompson, E O, George, C A, Poquette, P J, Cheshire, L B, Richmond, S S, de Graaf, M, Ma, C F, Stewart, P J, Houghton
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 5(11)
Topotecan and vincristine were evaluated alone or in combination against 13 independent xenografts and 1 vincristine-resistant derivative, representing childhood neuroblastoma (n = 6), rhabdomyosarcoma (n = 5), or brain tumors (n = 3). Topotecan was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eecd1cb2e27ac9258cb329986486706c
https://pubmed.ncbi.nlm.nih.gov/10589779
https://pubmed.ncbi.nlm.nih.gov/10589779
Autor:
M K, Danks, C L, Morton, E J, Krull, P J, Cheshire, L B, Richmond, C W, Naeve, C A, Pawlik, P J, Houghton, P M, Potter
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 5(4)
Several recent studies have examined the possibility of producing tumor-specific cytotoxicity with various enzyme/ prodrug combinations. The enzymes are targeted to tumor cells either with antibodies (ADEPT, antibody directed enzyme prodrug therapy)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::87c95de52649066d15612b2bd95c483a
https://pubmed.ncbi.nlm.nih.gov/10213229
https://pubmed.ncbi.nlm.nih.gov/10213229
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 4(8)
The camptothecin derivative topotecan has been postulated to mediate its antitumor effect through a drug-induced increase in covalent topoisomerase I-DNA complexes. If this hypothesis is correct, then schedules of exposure to topotecan that maximize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::92d72aa17580fdb092142183b495abbc
https://pubmed.ncbi.nlm.nih.gov/9717830
https://pubmed.ncbi.nlm.nih.gov/9717830
Autor:
W C, Zamboni, P J, Houghton, J, Thompson, P J, Cheshire, S K, Hanna, L B, Richmond, X, Lou, C F, Stewart
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 4(2)
The antitumor activity of irinotecan in vitro primarily results from its hydrolysis by carboxylesterase to the active metabolite SN-38. The present study was conducted to evaluate the effect of human neuroblastoma xenografts on irinotecan and SN-38 d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::39f24002a9213262cbe42a471d117875
https://pubmed.ncbi.nlm.nih.gov/9516936
https://pubmed.ncbi.nlm.nih.gov/9516936