Zobrazeno 1 - 10
of 114
pro vyhledávání: '"P H Krammer"'
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-14 (2022)
Abstract Background Uptake of apoptotic cells induces a tolerogenic phenotype in phagocytes and promotes peripheral tolerance. The highly conserved Annexin core domain, present in all members of the Annexin family, becomes exposed on the apoptotic ce
Externí odkaz:
https://doaj.org/article/de913e4683014135a2e3a6212974b092
Autor:
Julia Sieber‐Frank, Hans‐Jürgen Stark, Simon Kalteis, Elena‐Sophie Prigge, Richard Köhler, Carolin Andresen, Thomas Henkel, Georg Casari, Tobias Schubert, Wolfgang Fischl, Min Li‐Weber, Peter H. Krammer, Magnus vonKnebel Doeberitz, Jürgen Kopitz, Matthias Kloor, Aysel Ahadova
Publikováno v:
Cancer Medicine, Vol 10, Iss 19, Pp 6807-6822 (2021)
Abstract Rocaglates are natural compounds that have been extensively studied for their ability to inhibit translation initiation. Rocaglates represent promising drug candidates for tumor treatment due to their growth‐inhibitory effects on neoplasti
Externí odkaz:
https://doaj.org/article/c86b61b3c2344cd3b3e599e1e49f65ee
Publikováno v:
Autoimmunity, Vol 53, Iss 2, Pp 86-94 (2020)
Apoptotic cells mediate the development of tolerogenic dendritic cells (DC) and thus facilitate induction and maintenance of peripheral tolerance. Following the identification of the evolutionary conserved annexin core domain (Anx) as a specific sign
Externí odkaz:
https://doaj.org/article/9e9e6b883e174f1ca37b6f96f497ed74
Autor:
Kevin Bode, Fatmire Bujupi, Corinna Link, Tobias Hein, Stephanie Zimmermann, Diluka Peiris, Vincent Jaquet, Bernd Lepenies, Heiko Weyd, Peter H. Krammer
Publikováno v:
Cell Reports, Vol 29, Iss 13, Pp 4435-4446.e9 (2019)
Summary: Uptake of apoptotic cells (ACs) by dendritic cells (DCs) and induction of a tolerogenic DC phenotype is an important mechanism for establishing peripheral tolerance to self-antigens. The receptors involved and underlying signaling pathways a
Externí odkaz:
https://doaj.org/article/31132c112ccb4eda9e7c9bb04dcb514c
Autor:
Claudia Dürr, Bola S. Hanna, Angela Schulz, Fabienne Lucas, Manuela Zucknick, Axel Benner, Andrew Clear, Sibylle Ohl, Selcen Öztürk, Thorsten Zenz, Stephan Stilgenbauer, Min Li-Weber, Peter H. Krammer, John G. Gribben, Peter Lichter, Martina Seiffert
Publikováno v:
Haematologica, Vol 103, Iss 4 (2018)
Chronic lymphocytic leukemia is a malignancy of mature B cells that strongly depend on microenvironmental factors, and their deprivation has been identified as a promising treatment approach for this incurable disease. Cytokine array screening of 247
Externí odkaz:
https://doaj.org/article/7461f3c60f52471c8775596f026ea1d3
Autor:
Marcin M. Kamiński, Sven W. Sauer, Marian Kamiński, Silvana Opp, Thorsten Ruppert, Paulius Grigaravičius, Przemysław Grudnik, Hermann-Josef Gröne, Peter H. Krammer, Karsten Gülow
Publikováno v:
Cell Reports, Vol 2, Iss 5, Pp 1300-1315 (2012)
Mitochondria-originating reactive oxygen species (ROS) control T cell receptor (TCR)-induced gene expression. Here, we show that TCR-triggered activation of ADP-dependent glucokinase (ADPGK), an alternative, glycolytic enzyme typical for Archaea, med
Externí odkaz:
https://doaj.org/article/96ce577eec5b4fd6998e231b2ec9cac5
Autor:
Leo Neumann, Carina Pforr, Joel Beaudouin, Alexander Pappa, Nicolai Fricker, Peter H Krammer, Inna N Lavrik, Roland Eils
Publikováno v:
Molecular Systems Biology, Vol 6, Iss 1, Pp 1-17 (2010)
Abstract This study explores the dilemma in cellular signaling that triggering of CD95 (Fas/APO‐1) in some situations results in cell death and in others leads to the activation of NF‐κB. We established an integrated kinetic mathematical model f
Externí odkaz:
https://doaj.org/article/fb9c1a0332e54025bdad0fa858e65f10
Autor:
Heiko Weyd, Lucie Abeler-Dörner, Björn Linke, Andrea Mahr, Veronika Jahndel, Sandra Pfrang, Martina Schnölzer, Christine S Falk, Peter H Krammer
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e62449 (2013)
Prevention of an immune response against self-antigens derived from apoptotic cells is essential to preclude autoimmune and chronic inflammatory diseases. Here, we describe apoptosis induced externalization of endogenous cytosolic annexin 1 initiatin
Externí odkaz:
https://doaj.org/article/f103116bf0934379a50d1ab2f22e896f
Publikováno v:
Frontiers in Immunology, Vol 3 (2012)
CD4+CD25highFoxp3+ regulatory T cells (Tregs) can suppress other immune cells and, thus, are critical mediators of peripheral self-tolerance. On the one hand, Tregs prevent autoimmune disease and allergies. On the other hand, Tregs can avert immune r
Externí odkaz:
https://doaj.org/article/82599f0661e04c8d934f4b02c7b45f0e
Autor:
Kathrin Schuldt, Cosima C Kretz, Christian Timmann, Jürgen Sievertsen, Christa Ehmen, Claudia Esser, Wibke Loag, Daniel Ansong, Carmen Dering, Jennifer Evans, Andreas Ziegler, Jürgen May, Peter H Krammer, Tsiri Agbenyega, Rolf D Horstmann
Publikováno v:
PLoS Genetics, Vol 7, Iss 5, p e1002066 (2011)
Human genetics and immune responses are considered to critically influence the outcome of malaria infections including life-threatening syndromes caused by Plasmodium falciparum. An important role in immune regulation is assigned to the apoptosis-sig
Externí odkaz:
https://doaj.org/article/abb074d2235a42f384577f00bcbbcbe7