Výsledky vyhledávání - "P H Kazanjian"

5-Lipoxygenase metabolism in alveolar macrophages from subjects infected with the human immunodeficiency virus

Autor: M J Coffey, S M Phare, P H Kazanjian, M Peters-Golden

Publikováno v: The Journal of Immunology. 157:393-399

Pulmonary infection represents a major source of morbidity and mortality in AIDS. One important component of pulmonary host defense is the elaboration by resident alveolar macrophages (AM) of proinflammatory leukotrienes (LT) and other 5-lipoxygenase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::91fef7e104f02e197399c14c2d951e00
https://doi.org/10.4049/jimmunol.157.1.393

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Pharmacokinetics and bioavailability of fluconazole in patients with AIDS

Autor: Alan Forrest, L G Cohen, Joseph M. Scavone, P H Kazanjian, Josiah D. Rich, D DeMuria

Publikováno v: Antimicrobial Agents and Chemotherapy. 37:2187-2192

Fluconazole pharmacokinetics were evaluated for 10 volunteers with AIDS who had no clinical evidence of gastroenteritis. Single 100-mg intravenous (i.v.) and oral (p.o.) doses were administered in a randomized, crossover design. i.v. doses were deliv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7629c39148589a797ea8813592d63351
https://doi.org/10.1128/aac.37.10.2187

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Granulocyte-macrophage colony-stimulating factor upregulates reduced 5-lipoxygenase metabolism in peripheral blood monocytes and neutrophils in acquired immunodeficiency syndrome

Autor: M J, Coffey, S M, Phare, S, Cinti, M, Peters-Golden, P H, Kazanjian

Publikováno v: Blood. 94(11)

Leukotrienes (LT) are mediators derived from the 5-lipoxygenase (5-LO) pathway, which play a role in host defense, and are synthesized by both monocytes (peripheral blood monocyte [PBM]) and neutrophils (PMN). Because 5-LO metabolism is reduced in al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2ab739a5b610044766b6d0a68fd37b2c
https://pubmed.ncbi.nlm.nih.gov/10572106

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Spinal cord infection: myelitis and abscess formation

Autor: K J, Murphy, J A, Brunberg, D J, Quint, P H, Kazanjian

Publikováno v: AJNR Am J Neuroradiol

PURPOSE: Our purpose was to describe the MR findings and evolution of spinal cord abscess and to define those MR features that allow differentiation of cord infection from other intramedullary abnormalities. METHODS: We retrospectively reviewed the M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::22df3aa8b94fbf16cdb24cde4bbdcfa4
https://europepmc.org/articles/PMC8338200/

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5-Lipoxygenase metabolism in alveolar macrophages from subjects infected with the human immunodeficiency virus

Autor: M J, Coffey, S M, Phare, P H, Kazanjian, M, Peters-Golden

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 157(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::11b553fd8f937b48b4c6385cd0a74683
https://pubmed.ncbi.nlm.nih.gov/8683143

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Verapamil impairs human neutrophil chemotaxis by a non-calcium-mediated mechanism

Autor: J E, Pennington, B, Kemmerich, P H, Kazanjian, J D, Marsh, L W, Boerth

Publikováno v: The Journal of laboratory and clinical medicine. 108(1)

The in vitro effect of pharmacologic concentrations (10(-8) to 10(-6) mol/L) of verapamil on human neutrophil migration and response to chemotactic signals was examined. Human neutrophils were preincubated (15 minutes) in verapamil and then assayed f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6178f9cbd1200bcf6f92d3b75e7863e5
https://pubmed.ncbi.nlm.nih.gov/3711725

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