Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis.

Autor: Rosendahl J; Department of Internal Medicine I, Martin Luther University, Halle, Germany.; Department of Internal Medicine, Neurology and Dermatology, Division of Gastroenterology, University of Leipzig, Leipzig, Germany., Kirsten H; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.; LIFE- Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.; Department of Cell Therapy, Fraunhofer Institute for Cell Therapy and Immunology (IZI), Leipzig, Germany., Hegyi E; Department of Molecular and Cell Biology, Center for Exocrine Disorders, Boston University Henry M. Goldman School of Dental Medicine, Boston, Massachusetts, USA., Kovacs P; Leipzig University Medical Center, IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany., Weiss FU; Department of Internal Medicine A, Ernst-Moritz-Arndt University, Greifswald, Germany., Laumen H; Else Kröner-Fresenius-Zentrum für Ernährungsmedizin (EKFZ), Paediatric Nutritional Medicine, Technische Universität München (TUM), Freising, Germany., Lichtner P; Institute of Human Genetics, Helmholtz Centre Munich, German Research Centre for Environmental Health, Neuherberg, Germany., Ruffert C; Department of Internal Medicine I, Martin Luther University, Halle, Germany., Chen JM; Institut National de la Santé et de la Recherche Médicale (INSERM) U1078; Etablissement Français du Sang (EFS) - Bretagne; Faculté de Médecine et des Sciences de la Santé, Université de Bretagne Occidentale; Laboratoire de Génétique Moléculaire et d'Histocompatibilité, Centre Hospitalier Régional Universitaire (CHRU) Brest, Hôpital Morvan, Brest, France., Masson E; Institut National de la Santé et de la Recherche Médicale (INSERM) U1078; Etablissement Français du Sang (EFS) - Bretagne; Faculté de Médecine et des Sciences de la Santé, Université de Bretagne Occidentale; Laboratoire de Génétique Moléculaire et d'Histocompatibilité, Centre Hospitalier Régional Universitaire (CHRU) Brest, Hôpital Morvan, Brest, France., Beer S; Department of Internal Medicine, Neurology and Dermatology, Division of Gastroenterology, University of Leipzig, Leipzig, Germany., Zimmer C; Department of Internal Medicine, Neurology and Dermatology, Division of Gastroenterology, University of Leipzig, Leipzig, Germany., Seltsam K; Department of Internal Medicine, Neurology and Dermatology, Division of Gastroenterology, University of Leipzig, Leipzig, Germany., Algül H; Department of Gastroenterology, Technische Universität München (TUM), Munich, Germany., Bühler F; Else Kröner-Fresenius-Zentrum für Ernährungsmedizin (EKFZ), Paediatric Nutritional Medicine, Technische Universität München (TUM), Freising, Germany., Bruno MJ; Department of Gastroenterology & Hepatology, Erasmus Medical Centre, University Medical Centre Rotterdam, Rotterdam, The Netherlands., Bugert P; Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, German Red Cross Blood Service of Baden-Württemberg, Mannheim, Germany., Burkhardt R; LIFE- Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany., Cavestro GM; Division of Gastroenterology and Gastrointestinal Endoscopy, Vita Salute San Raffaele University - San Raffaele Scientific Institute, Milan, Italy., Cichoz-Lach H; Department of Gastroenterology, Medical University of Lublin, Lublin, Poland., Farré A; Department of Gastroenterology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain., Frank J; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany., Gambaro G; Division of Nephrology and Dialysis, Institute of Internal Medicine, Renal Program, Columbus-Gemelli University Hospital, Catholic University, Rome, Italy., Gimpfl S; Else Kröner-Fresenius-Zentrum für Ernährungsmedizin (EKFZ), Paediatric Nutritional Medicine, Technische Universität München (TUM), Freising, Germany., Grallert H; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany., Griesmann H; Department of Internal Medicine I, Martin Luther University, Halle, Germany., Grützmann R; Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Chirurgische Klinik, Erlangen, Germany., Hellerbrand C; Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany., Hegyi P; Institute for Translational Medicine and First Department of Internal Medicine, University of Pécs, Pécs, Hungary.; HAS-SZTE, Momentum Gastroenterology Multidisciplinary Research Group, Szeged, Hungary., Hollenbach M; Department of Internal Medicine I, Martin Luther University, Halle, Germany., Iordache S; Department of Internal Medicine and Gastroenterology, University of Medicine and Pharmacy, Craiova, Romania., Jurkowska G; Department of Gastroenterology and Internal Medicine, Medical University Bialystok, Bialystok, Poland., Keim V; Department of Internal Medicine, Neurology and Dermatology, Division of Gastroenterology, University of Leipzig, Leipzig, Germany., Kiefer F; Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany., Krug S; Department of Internal Medicine I, Martin Luther University, Halle, Germany., Landt O; TIB MOLBIOL, Berlin, Germany., Leo MD; Division of Gastroenterology and Gastrointestinal Endoscopy, Vita Salute San Raffaele University - San Raffaele Scientific Institute, Milan, Italy., Lerch MM; Department of Internal Medicine A, Ernst-Moritz-Arndt University, Greifswald, Germany., Lévy P; Pôle des Maladies de l'Appareil Digestif, Service de Gastroentérologie-Pancréatologie, Hôpital Beaujon, AP-HP, Clichy, France., Löffler M; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.; LIFE- Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany., Löhr M; Gastrocentrum, Karolinska Institutet CLINTEC, Stockholm, Sweden., Ludwig M; Else Kröner-Fresenius-Zentrum für Ernährungsmedizin (EKFZ), Paediatric Nutritional Medicine, Technische Universität München (TUM), Freising, Germany., Macek M; Department of Biology and Medical Genetics, University Hospital Motol and 2nd Faculty of Medicine, Charles University, Prague, Czech Republic., Malats N; Grupo de Epidemiología Genética y Molecular Programa de Genética del Cáncer Humano Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain.; CIBERONC, Spain., Malecka-Panas E; Department of Digestive Tract Diseases, Medical University of Łódź, Łódź, Poland., Malerba G; Biology and Genetics, Department of Life and Reproduction Sciences, University of Verona, Verona, Italy., Mann K; Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany., Mayerle J; Department of Medicine II, University Hospital,Ludwig-Maximilians-University Munich, Munich, Germany., Mohr S; Else Kröner-Fresenius-Zentrum für Ernährungsmedizin (EKFZ), Paediatric Nutritional Medicine, Technische Universität München (TUM), Freising, Germany., Te Morsche RHM; Department of Gastroenterology and Hepatology, Radboud umc, Nijmegen, The Netherlands., Motyka M; Else Kröner-Fresenius-Zentrum für Ernährungsmedizin (EKFZ), Paediatric Nutritional Medicine, Technische Universität München (TUM), Freising, Germany., Mueller S; Department of Internal Medicine, Salem Medical Centre and Centre for Alcohol Research, University of Heidelberg, Heidelberg, Germany., Müller T; Department of Pediatrics I, Medical University, Innsbruck, Austria., Nöthen MM; Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.; Institute of Human Genetics, University of Bonn, Bonn, Germany., Pedrazzoli S; Department of Medical and Surgical Sciences, IV Surgical Clinic, University of Padua, Padua, Italy., Pereira SP; Division of Medicine, UCL Institute for Liver and Digestive Health, University College London, London, UK., Peters A; Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany., Pfützer R; Clinic for Internal Medicine, Hospital Döbeln, Döbeln, Germany., Real FX; CIBERONC, Spain.; Epithelial Carcinogenesis Group, Molecular Pathology Programme, Centro Nacional de Investigaciones Oncológicas, Madrid, Spain.; Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain., Rebours V; Pôle des Maladies de l'Appareil Digestif, Service de Gastroentérologie-Pancréatologie, Hôpital Beaujon, AP-HP, Clichy, France., Ridinger M; Department of Psychiatry, University of Regensburg, Regensburg, Germany., Rietschel M; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany., Rösmann E; Else Kröner-Fresenius-Zentrum für Ernährungsmedizin (EKFZ), Paediatric Nutritional Medicine, Technische Universität München (TUM), Freising, Germany., Saftoiu A; Department of Internal Medicine and Gastroenterology, University of Medicine and Pharmacy, Craiova, Romania., Schneider A; Department of Gastroenterology, Hepatology, Infectious Diseases, Medical Faculty of Mannheim University of Heidelberg, Mannheim, Germany., Schulz HU; Department of Surgery, Otto-von-Guericke University Magdeburg, Magdeburg, Germany., Soranzo N; The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Soyka M; Psychiatric Hospital, University of Munich, Munich, Germany., Simon P; Department of Internal Medicine A, Ernst-Moritz-Arndt University, Greifswald, Germany., Skipworth J; Department of Surgery and Interventional Science, University College London, London, UK., Stickel F; Department of Gastroenterology and Hepatology, University Hospital of Zürich, Zürich, Switzerland., Strauch K; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany., Stumvoll M; Leipzig University Medical Center, IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany.; Department of Internal Medicine, Neurology and Dermatology, Division of Endocrinology, University of Leipzig, Leipzig, Germany., Testoni PA; Division of Gastroenterology and Gastrointestinal Endoscopy, Vita Salute San Raffaele University - San Raffaele Scientific Institute, Milan, Italy., Tönjes A; Department of Internal Medicine, Neurology and Dermatology, Division of Endocrinology, University of Leipzig, Leipzig, Germany., Werner L; Else Kröner-Fresenius-Zentrum für Ernährungsmedizin (EKFZ), Paediatric Nutritional Medicine, Technische Universität München (TUM), Freising, Germany., Werner J; Department of General, Visceral, and Transplant Surgery, Ludwig Maximilian University, Munich, Germany., Wodarz N; Department of Psychiatry, University of Regensburg, Regensburg, Germany., Ziegler M; Else Kröner-Fresenius-Zentrum für Ernährungsmedizin (EKFZ), Paediatric Nutritional Medicine, Technische Universität München (TUM), Freising, Germany., Masamune A; Division of Gastroenterology, Tohoku University Graduate School of Medicine, SendaiMiyagi, Japan., Mössner J; Department of Internal Medicine, Neurology and Dermatology, Division of Gastroenterology, University of Leipzig, Leipzig, Germany., Férec C; Institut National de la Santé et de la Recherche Médicale (INSERM) U1078; Etablissement Français du Sang (EFS) - Bretagne; Faculté de Médecine et des Sciences de la Santé, Université de Bretagne Occidentale; Laboratoire de Génétique Moléculaire et d'Histocompatibilité, Centre Hospitalier Régional Universitaire (CHRU) Brest, Hôpital Morvan, Brest, France., Michl P; Department of Internal Medicine I, Martin Luther University, Halle, Germany., P H Drenth J; Department of Gastroenterology and Hepatology, Radboud umc, Nijmegen, The Netherlands., Witt H; Else Kröner-Fresenius-Zentrum für Ernährungsmedizin (EKFZ), Paediatric Nutritional Medicine, Technische Universität München (TUM), Freising, Germany., Scholz M; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.; LIFE- Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany., Sahin-Tóth M; Department of Molecular and Cell Biology, Center for Exocrine Disorders, Boston University Henry M. Goldman School of Dental Medicine, Boston, Massachusetts, USA.

Publikováno v: Gut [Gut] 2018 Oct; Vol. 67 (10), pp. 1855-1863. Date of Electronic Publication: 2017 Jul 28.