Healthy and diseased corticospinal motor neurons are selectively transduced upon direct AAV2-2 injection into the motor cortex

Autor: Yongling Zhu, Steven H. DeVries, P H Özdinler, Macdonell J. Stanford, William W. Hauswirth, Michael William Tu, Martha C. Bohn, Javier H. Jara

Publikováno v: Gene Therapy

Direct gene delivery to the neurons of interest, without affecting other neuron populations in the cerebral cortex, represent a challenge owing to the heterogeneity and cellular complexity of the brain. Genetic modulation of corticospinal motor neuro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e788ed1a3acc8aba99635c788686ce0
https://doi.org/10.1038/gt.2015.112

Clickable, Thermally Responsive Hydrogels Enabled by Recombinant Spider Silk Protein and Spy Chemistry for Sustained Neurotrophin Delivery.

Autor: Li Y; Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China., Yang C; Division of Life Science, State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China., Fang S; Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China., Zhou Y; Division of Life Science, State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China., Li M; Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China., Liu Z; Division of Life Science, State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China., Zhang X; Division of Life Science, State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China., Duan L; Department of Biomedical Engineering, The Chinese University of Hong Kong, Sha Tin, Hong Kong SAR, China., Liu K; Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China.; Division of Life Science, State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China.; Biomedical Research Institute, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen, 518036, China.; Guangdong Provincial Key Laboratory of Brain Science, Disease and Drug Development, HKUST Shenzhen Research Institute, Shenzhen-Hong Kong Institute of Brain Science, Shenzhen, Guangdong, 518057, China., Sun F; Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China.; Biomedical Research Institute, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen, 518036, China.; Greater Bay Biomedical InnoCenter, Shenzhen Bay Laboratory, Shenzhen, 518036, China.; HKUST Shenzhen Research Institute, Shenzhen, 518057, China.

Publikováno v: Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2024 Dec 08, pp. e2413957. Date of Electronic Publication: 2024 Dec 08.

Systemic Brain Delivery of Antisense Oligonucleotides across the Blood–Brain Barrier with a Glucose‐Coated Polymeric Nanocarrier.

Autor: Min, Hyun Su¹ (AUTHOR), Kim, Hyun Jin² (AUTHOR), Naito, Mitsuru² (AUTHOR), Ogura, Satomi¹ (AUTHOR), Toh, Kazuko³ (AUTHOR), Hayashi, Kotaro³ (AUTHOR), Kim, Beob Soo¹ (AUTHOR), Fukushima, Shigeto³ (AUTHOR), Anraku, Yasutaka^3,4 (AUTHOR), Miyata, Kanjiro¹ (AUTHOR) miyata@bmw.t.u-tokyo.ac.jp, Kataoka, Kazunori^3,5 (AUTHOR) kataoka@ifi.u-tokyo.ac.jp

Publikováno v: Angewandte Chemie. 5/18/2020, Vol. 132 Issue 21, p8250-8257. 8p.

Antisense therapy in a rat model of Alexander disease reverses GFAP pathology, white matter deficits, and motor impairment.

Autor: Hagemann, Tracy L., Powers, Berit, Lin, Ni-Hsuan, Mohamed, Ahmed F., Dague, Katerina L., Hannah, Seth C., Bachmann, Gemma, Mazur, Curt, Rigo, Frank, Olsen, Abby L., Feany, Mel B., Perng, Ming-Der, Berman, Robert F., Messing, Albee

Publikováno v: Science Translational Medicine; 11/17/2021, Vol. 13 Issue 620, p1-16, 16p

Directed Axonal Outgrowth Using a Propagating Gradient of IGF-1.

Autor: Lee, Wonjae, Frank, Curtis W., Park, Jon

Publikováno v: Advanced Materials; Aug2014, Vol. 26 Issue 29, p4936-4940, 5p