Zobrazeno 1 - 10
of 14
pro vyhledávání: '"P H, Ratz"'
Autor:
Yi Huang, Corey A. Smith, Grace Chen, Bharti Sharma, Amy S. Miner, Robert W. Barbee, Paul H. Ratz
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
Although recent studies reveal that activation of the metabolic and Ca2+ sensor AMPK strongly inhibits smooth muscle contraction, there is a paucity of information about the potential linkage between pharmacological AMPK activation and vascular smoot
Externí odkaz:
https://doaj.org/article/b95e150281f543989a9593629187dfd4
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
Metabolic stress diminishes smooth muscle contractile strength by a poorly defined mechanism. To test the hypothesis that metabolic stress activates a compensatory cell signaling program to reversibly downregulate contraction, arterial rings and blad
Externí odkaz:
https://doaj.org/article/b333876a1c184fd2b52f0eb22378d8a2
Autor:
Yi Huang, Paul H. Ratz, Amy S. Miner, Victoria A. Locke, Grace Chen, Yang Chen, Robert W. Barbee
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
Background: Many strategies have been utilized to treat traumatic shock via improved oxygen delivery (DO2), while fewer have been used to in an attempt to reduce oxygen demand (VO2). The cellular energy sensor 5′ adenosine monophosphate-activated p
Externí odkaz:
https://doaj.org/article/c2f6ca62ac734f8ebc7e36955214920d
Publikováno v:
Methods in molecular medicine. 51
The blood vessels that contribute most to precapillary resistance are known as resistance arteries, consisting of arterioles and small arteries with diameters of less than 500 μm (1). These vessels regulate the vascular resistance, and thus the bloo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::972b0c89b604839f8a5af285445931dc
https://pubmed.ncbi.nlm.nih.gov/21331737
https://pubmed.ncbi.nlm.nih.gov/21331737
Publikováno v:
Journal of vascular research. 37(6)
Previous studies demonstrated that maintenance of steady-state myogenic tone requires Ca(2+)-dependent myosin phosphorylation. The present studies furthered these observations by examining temporal relationships among Ca(2+), myosin phosphorylation a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d981e1b25a435738cf15522b9f2e6b7f
https://pubmed.ncbi.nlm.nih.gov/11146410
https://pubmed.ncbi.nlm.nih.gov/11146410
Publikováno v:
The Journal of urology. 162(5)
Recent evidence suggests that sex steroids may produce rapid inhibition of voltage operated Ca2+ channels (VOCCs). Detrusor smooth muscle is highly dependent upon Ca2+ influx for receptor-activated contractions. Thus, we examined the relative effecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::37504737d99a0d728756fc4e4081622a
https://pubmed.ncbi.nlm.nih.gov/10524942
https://pubmed.ncbi.nlm.nih.gov/10524942
Publikováno v:
Journal of vascular research. 33(6)
alpha 1-Adrenoceptor agonists not only contract rabbit femoral arteries, but also desensitize them so that the strength of subsequent contractions induced by 110 mM KCl is reduced. To determine the mechanisms by which this postreceptor desensitizatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::439c096ec5c71d4430efbb44d32f9635
https://pubmed.ncbi.nlm.nih.gov/8998198
https://pubmed.ncbi.nlm.nih.gov/8998198
Autor:
P H, Ratz, P F, Blackmore
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 254(2)
The effect of fluoride (NaF; 10 mM sodium fluoride plus deferoxamine to chelate contaminating aluminum) and fluoride plus aluminum fluorides (AlF; 10 mM sodium fluoride plus 20 microM aluminum chloride) on activation of rabbit femoral arteries was in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6f336e3965584b89dd0ccbc7464d8521
https://pubmed.ncbi.nlm.nih.gov/2166793
https://pubmed.ncbi.nlm.nih.gov/2166793
Autor:
P H, Ratz
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 252(1)
Smooth muscle contractile agents cause large increases in crossbridge phosphorylation (Mp) and cycling rates resulting in the rapid development of stress (force/muscle cross-sectional area). Despite temporal declines in Mp and cycling during continue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d33b73ebe4263cc10e2abc3f5c810e52
https://pubmed.ncbi.nlm.nih.gov/2299593
https://pubmed.ncbi.nlm.nih.gov/2299593
Autor:
P H Ratz, R A Murphy
Publikováno v:
Circulation Research. 60:410-421
Contractile agonists can mobilize Ca2+ from both intracellular and extracellular stores in smooth muscle. This study addresses the role of Ca2+ mobilization as it relates to the complex manner by which Ca2+ regulates the contractile system in smooth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c5286dffa6358ee31a7e1b00a486e4
https://doi.org/10.1161/01.res.60.3.410
https://doi.org/10.1161/01.res.60.3.410