Zobrazeno 1 - 10
of 29
pro vyhledávání: '"P H, Rabbitts"'
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract The transcription factor complex, consisting of LMO2, TAL1 or LYL1, and GATA2, plays an important role in capillary sprouting by regulating VEGFR2, DLL4, and angiopoietin 2 in tip cells. Overexpression of the basic helix-loop-helix transcrip
Externí odkaz:
https://doaj.org/article/4b8dfdc91bf24abbb634c6378bb8698a
Autor:
T. H. Rabbitts
Publikováno v:
Antibodies, Vol 12, Iss 1, p 24 (2023)
The application of antibodies in cells was first shown in the early 1990s, and subsequently, the field of intracellular antibodies has expanded to encompass antibody fragments and their use in target validation and as engineered molecules that can be
Externí odkaz:
https://doaj.org/article/7e2f6376499e416a90523cb8fbe48e97
Autor:
Nicolas Bery, Sandrine Legg, Judit Debreczeni, Jason Breed, Kevin Embrey, Christopher Stubbs, Paulina Kolasinska-Zwierz, Nathalie Barrett, Rose Marwood, Jo Watson, Jon Tart, Ross Overman, Ami Miller, Christopher Phillips, Ralph Minter, Terence H. Rabbitts
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Mutant RAS family members occur in a wide range of tumour types, and there is a great interest in identifying isoform-specific inhibitors. Here, the authors characterise two designed ankyrin repeat proteins (DARPins) that specifically inhibit the KRA
Externí odkaz:
https://doaj.org/article/d60832bba2a448e1bd87fa3edb2b14fd
Autor:
Camilo E. Quevedo, Abimael Cruz-Migoni, Nicolas Bery, Ami Miller, Tomoyuki Tanaka, Donna Petch, Carole J. R. Bataille, Lydia Y. W. Lee, Phillip S. Fallon, Hanna Tulmin, Matthias T. Ehebauer, Narcis Fernandez-Fuentes, Angela J. Russell, Stephen B. Carr, Simon E. V. Phillips, Terence H. Rabbitts
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Intracellular antibodies can inhibit disease-relevant protein interactions, but inefficient cellular uptake limits their utility. Using a RAS-targeting intracellular antibody as a screening tool, the authors here identify small molecules that inhibit
Externí odkaz:
https://doaj.org/article/67c80be1d0a14b3aa0feecf6b7e3b832
Autor:
Nicolas Bery, Abimael Cruz-Migoni, Carole JR Bataille, Camilo E Quevedo, Hanna Tulmin, Ami Miller, Angela Russell, Simon EV Phillips, Stephen B Carr, Terence H Rabbitts
Publikováno v:
eLife, Vol 7 (2018)
Externí odkaz:
https://doaj.org/article/0028094ef6084440acfe4482bdeb55d9
Autor:
Nicolas Bery, Abimael Cruz-Migoni, Carole JR Bataille, Camilo E Quevedo, Hanna Tulmin, Ami Miller, Angela Russell, Simon EV Phillips, Stephen B Carr, Terence H Rabbitts
Publikováno v:
eLife, Vol 7 (2018)
The RAS family of proteins is amongst the most highly mutated in human cancers and has so far eluded drug therapy. Currently, much effort is being made to discover mutant RAS inhibitors and in vitro screening for RAS-binding drugs must be followed by
Externí odkaz:
https://doaj.org/article/6d8a1e8ab8724fc883df0eb1fdb7cab0
Autor:
Laura Keller, Nicolas Bery, Claudine Tardy, Laetitia Ligat, Gilles Favre, Terence H. Rabbitts, Aurélien Olichon
Publikováno v:
Antibodies, Vol 8, Iss 1, p 8 (2019)
RHO (Ras HOmologous) GTPases are molecular switches that activate, in their state bound to Guanosine triphosphate (GTP), key signaling pathways, which involve actin cytoskeleton dynamics. Previously, we selected the nanobody RH12, from a synthetic ph
Externí odkaz:
https://doaj.org/article/a599c94784c342ad9b7e7b39647d0052
Publikováno v:
Antibodies, Vol 2, Iss 2, Pp 306-320 (2013)
Many human diseases are caused by mutant or abnormal protein functions that are largely confined to the inside of cells, rather than being displayed on the abnormal cell surface. Furthermore, many of the functional consequences of aberrant proteins,
Externí odkaz:
https://doaj.org/article/6aad488f5d2e4f50bbaa9e99f2600b15
Autor:
Jennifer Chambers, Terence H. Rabbitts
Publikováno v:
Open Biology, Vol 5, Iss 6 (2015)
LMO2 was first discovered through proximity to frequently occurring chromosomal translocations in T cell acute lymphoblastic leukaemia (T-ALL). Subsequent studies on its role in tumours and in normal settings have highlighted LMO2 as an archetypical
Externí odkaz:
https://doaj.org/article/e6c36b6da2764e209da516961449c93c
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64546 (2013)
Metagenomics, the study of microbial genomes within diverse environments, is a rapidly developing field. The identification of microbial sequences within a host organism enables the study of human intestinal, respiratory, and skin microbiota, and has
Externí odkaz:
https://doaj.org/article/6074257214fc4752b35a09f62e4e3748