Zobrazeno 1 - 10
of 13
pro vyhledávání: '"P H, O'Farrell"'
Autor:
Chun-Yi Cho, Patrick H. O’Farrell
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Binding of transcription factors (TFs) promotes the subsequent recruitment of coactivators and preinitiation complexes to initiate eukaryotic transcription, but this time course is usually not visualized. It is commonly assumed that recruite
Externí odkaz:
https://doaj.org/article/bc36d92fb1644f4d8846d4c05411c353
Publikováno v:
PLoS Biology, Vol 18, Iss 10, p e3000891 (2020)
Externally deposited eggs begin development with an immense cytoplasm and a single overwhelmed nucleus. Rapid mitotic cycles restore normality as the ratio of nuclei to cytoplasm (N/C) increases. A threshold N/C has been widely proposed to activate z
Externí odkaz:
https://doaj.org/article/5bf733b42e744183bf4451ede272fc4f
Publikováno v:
Disease Models & Mechanisms, Vol 10, Iss 12, Pp 1381-1389 (2017)
For hundreds of years, biologists have studied accessible organisms such as garden peas, sea urchins collected at low tide, newt eggs, and flies circling rotten fruit. These organisms help us to understand the world around us, attracting and inspirin
Externí odkaz:
https://doaj.org/article/8cb9b4eaaa5d430a995436f5e44beb81
Autor:
Charles A Seller, Patrick H O'Farrell
Publikováno v:
PLoS Biology, Vol 16, Iss 5, p e2005687 (2018)
In preparation for dramatic morphogenetic events of gastrulation, rapid embryonic cell cycles slow at the mid-blastula transition (MBT). In Drosophila melanogaster embryos, down-regulation of cyclin-dependent kinase 1 (Cdk1) activity initiates this s
Externí odkaz:
https://doaj.org/article/ed0533bafc6944e0bbb04bef6305c135
Autor:
Hansong Ma, Patrick H O'Farrell
Publikováno v:
eLife, Vol 4 (2015)
Homologous recombination is widespread and catalyzes evolution. Nonetheless, its existence in animal mitochondrial DNA is questioned. We designed selections for recombination between co-resident mitochondrial genomes in various heteroplasmic Drosophi
Externí odkaz:
https://doaj.org/article/07369606c61046c988aba76e4153a663
Publikováno v:
PLoS Biology, Vol 4, Iss 1, p e4 (2006)
Phagocytosis is a highly conserved aspect of innate immunity. We used Drosophila melanogaster S2 cells as a model system to study the phagocytosis of Candida albicans, the major fungal pathogen of humans, by screening an RNAi library representing 7,2
Externí odkaz:
https://doaj.org/article/9eb4411e59924036bc4130f32f3a378c
Autor:
Edan Foley, Patrick H O'Farrell
Publikováno v:
PLoS Biology, Vol 2, Iss 8, p E203 (2004)
The innate immune system is ancient and highly conserved. It is the first line of defense and the only recognizable immune system in the vast majority of metazoans. Signaling events that convert pathogen detection into a defense response are central
Externí odkaz:
https://doaj.org/article/9f5bea5bb7ba4cac965b1274e5e12cec
Autor:
R J, Duronio, P H, O'Farrell
Publikováno v:
Development. 120:1503-1515
We have defined a coordinate program of transcription of S-phase genes (DNA polymerase α, PCNA and the two ribonucleotide reductase subunits) that can be induced by the G1 cyclin, cyclin E. In Drosophila embryos, this program drives an intricate spa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d95b1080a4f2b9283a23a46b2caff12
https://doi.org/10.1242/dev.120.6.1503
https://doi.org/10.1242/dev.120.6.1503
Autor:
C H, Girdham, P H, O'Farrell
Publikováno v:
Methods in cell biology. 44
Photoactivatable lineage tracers represent a major advance for clonal analysis in the early embryo and the study of cell movements. Any cell in the blastoderm can be marked, and the nuclear localization of the signal allows excellent resolution in id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4bb772b3dd864b45bf9668b27e4ae9b9
https://pubmed.ncbi.nlm.nih.gov/7535883
https://pubmed.ncbi.nlm.nih.gov/7535883
Publikováno v:
Journal of Cell Science; October 2001, Vol. 114 Issue: 19 p3445-54, 10p