Zobrazeno 1 - 10
of 87
pro vyhledávání: '"P H, Howarth"'
Autor:
Valentyna Yasinska, Cristina Gómez, Johan Kolmert, Magnus Ericsson, Anton Pohanka, Anna James, Lars I. Andersson, Maria Sparreman-Mikus, Ana R. Sousa, John H. Riley, Stewart Bates, Per S. Bakke, Nazanin Zounemat Kermani, Massimo Caruso, Pascal Chanez, Stephen J. Fowler, Thomas Geiser, Peter H. Howarth, Ildikó Horváth, Norbert Krug, Paolo Montuschi, Marek Sanak, Annelie Behndig, Dominick E. Shaw, Richard G. Knowles, Barbro Dahlén, Anke-Hilse Maitland-van der Zee, Peter J. Sterk, Ratko Djukanovic, Ian M. Adcock, Kian Fan Chung, Craig E. Wheelock, Sven-Erik Dahlén, Eva Wikström Jonsson, H. Ahmed
Publikováno v:
ERJ Open Research, Vol 9, Iss 5 (2023)
Rationale Patients with severe asthma are dependent upon treatment with high doses of inhaled corticosteroids (ICS) and often also oral corticosteroids (OCS). The extent of endogenous androgenic anabolic steroid (EAAS) suppression in asthma has not p
Externí odkaz:
https://doaj.org/article/a7fc69aad4384962865d87d94aff46ed
Autor:
Christer Janson, Leif Bjermer, Lauri Lehtimäki, Hannu Kankaanranta, Jussi Karjalainen, Alan Altraja, Valentyna Yasinska, Bernt Aarli, Madeleine Rådinger, Johan Hellgren, Magnus Lofdahl, Peter H Howarth, Celeste Porsbjerg
Publikováno v:
European Clinical Respiratory Journal, Vol 9, Iss 1 (2022)
Eosinophils have a broad range of functions, both homeostatic and pathological, mediated through an array of cell surface receptors and specific secretory granules that promote interactions with their microenvironment. Eosinophil development, differe
Externí odkaz:
https://doaj.org/article/cafaba4b62ec41c0be49070ccc7baacd
Autor:
Ian D. Pavord, Roland Buhl, Monica Kraft, Charlene M. Prazma, Robert G. Price, Peter H. Howarth, Steven W. Yancey
Publikováno v:
ERJ Open Research, Vol 8, Iss 2 (2022)
Externí odkaz:
https://doaj.org/article/76317a21f29a45408905b93037f416d6
Autor:
Uruj Hoda, Stelios Pavlidis, Aruna T. Bansal, Kentaro Takahashi, Sile Hu, Francois Ng Kee Kwong, Christos Rossios, Kai Sun, Pankaj Bhavsar, Matthew Loza, Frederic Baribaud, Pascal Chanez, Stephen J. Fowler, Ildiko Horvath, Paolo Montuschi, Florian Singer, Jacek Musial, Barbro Dahlen, Norbert Krug, Thomas Sandstrom, Dominic E. Shaw, Rene Lutter, Louise J. Fleming, Peter H. Howarth, Massimo Caruso, Ana R. Sousa, Julie Corfield, Charles Auffray, Bertrand De Meulder, Diane Lefaudeux, Sven‐Erik Dahlen, Ratko Djukanovic, Peter J. Sterk, Yike Guo, Ian M. Adcock, Kian Fan Chung, the U‐BIOPRED study group
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 4, Pp n/a-n/a (2022)
Abstract Background Exacerbation‐prone asthma is a feature of severe disease. However, the basis for its persistency remains unclear. Objectives To determine the clinical and transcriptomic features of frequent exacerbators (FEs) and persistent FEs
Externí odkaz:
https://doaj.org/article/472cffbdc9ba4c16ac2d4d6cd89330da
Autor:
Catherine E. Hanratty, John G. Matthews, Joseph R. Arron, David F. Choy, Ian D. Pavord, P. Bradding, Christopher E. Brightling, Rekha Chaudhuri, Douglas C. Cowan, Ratko Djukanovic, Nicola Gallagher, Stephen J. Fowler, Tim C. Hardman, Tim Harrison, Cécile T. Holweg, Peter H. Howarth, James Lordan, Adel H. Mansur, Andrew Menzies-Gow, Sofia Mosesova, Robert M. Niven, Douglas S. Robinson, Dominick E. Shaw, Samantha Walker, Ashley Woodcock, Liam G. Heaney, on behalf of the RASP-UK (Refractory Asthma Stratification Programme) Consortium
Publikováno v:
Trials, Vol 19, Iss 1, Pp 1-13 (2018)
Abstract Background Patients with difficult-to-control asthma consume 50–60% of healthcare costs attributed to asthma and cost approximately five-times more than patients with mild stable disease. Recent evidence demonstrates that not all patients
Externí odkaz:
https://doaj.org/article/8b2b5c94718a45699e6b6b269b64f460
Autor:
Rosalia Emma, Aruna T Bansal, Johan Kolmert, Craig E Wheelock, Swen-Erik Dahlen, Matthew J Loza, Bertrand De Meulder, Diane Lefaudeux, Charles Auffray, Barbro Dahlen, Per S Bakke, Pascal Chanez, Stephen J Fowler, Ildiko Horvath, Paolo Montuschi, Norbert Krug, Marek Sanak, Thomas Sandstrom, Dominick E Shaw, Louise J Fleming, Ratko Djukanovic, Peter H Howarth, Florian Singer, Ana R Sousa, Peter J Sterk, Julie Corfield, Ioannis Pandis, Kian F Chung, Ian M Adcock, René Lutter, Lorena Fabbella, Massimo Caruso, U-BIOPRED Study Group
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0203874 (2018)
Oxidative stress is believed to be a major driver of inflammation in smoking asthmatics. The U-BIOPRED project recruited a cohort of Severe Asthma smokers/ex-smokers (SAs/ex) and non-smokers (SAn) with extensive clinical and biomarker information ena
Externí odkaz:
https://doaj.org/article/a176a9f785e1455ab33c06826982b773
Autor:
P. J. Sterk, John H. Riley, Thomas Sandström, Anna Selby, Laurie Pahus, C. Auffray, Ioannis Pandis, Julie Corfield, R. Djukanovic, K. Sun, Massimo Caruso, Jørgen Vestbo, Matthew J. Loza, Andrew J. Simpson, Dominic Burg, I.M. Adcock, S. Bates, Scott Wagers, Ana R. Sousa, J. Corfield, Ariane H. Wagener, René Lutter, Barbro Dahlén, Ratko Djukanovic, G. Praticò, I. Pandis, N. Mores, G. Hedlin, Navin Rao, I. Horváth, Alexander Mazein, B. De Meulder, Richard G. Knowles, John-Olof Thörngren, Wolfgang Seibold, P H Howarth, Victoria M. Goss, Cristina Gómez, Clare S. Murray, Paul Brinkman, Ildiko Horvath, Anthony D. Postle, M. Caruso, Martina Gahlemann, M. Puig Valls, F.K. Chung, P. Montuschi, Dominick E. Shaw, Kai Sun, Aruna T. Bansal, Fahad Alahmadi, Amphun Chaiboonchoe, Graham Roberts, Kian Fan Chung, Yike Guo, H. Ahmed, Thomas Geiser, Klaus Bønnelykke, M. Miralpeix, Simone Hashimoto, Diane Lefaudeux, S.S. Wagers, D. Erzen, B. Thornton, Florian Singer, Louise Fleming, Stephen J. Fowler, Neil Fitch, P. Bakke, Craig E. Wheelock, Nadja Hawwa Vissing, Tim Higenbottam, Jamie Matthews, F. Singer, S.E. Dahlén, Sarah Masefield, Roelinde Middelveld, Jens M. Hohlfeld, Anthony V. D'Amico, Paul Skipp, W.M.C. van Aalderen, Alan J. Knox, Sven-Erik Dahlén, Andrew Bush, A.T. Bansal, Pieter-Paul Hekking, Joost Brandsma, Stewart Bates, L.J. Fleming, Norbert Krug, N. Krug, Magnus Ericsson, J. Riley, P. Powel, Jacek Musiał, Amanda Roberts, Peter J. Sterk, Ian M. Adcock, Pascal Chanez, Cecile T.J. Holweg, F. Baribaud, Stelios Pavlidis, Veit J. Erpenbeck, Z. Weiszhart, C.E. Wheelock, Ralf Sigmund, James P.R. Schofield, Alexander Manta, Andrea Meiser, Susan J. Wilson, Jeanette Bigler, G. Roberts, M. van Geest, Hans Bisgaard, Urs Frey, Michael Boedigheimer, Per Bakke, Chris Compton, Enrica Bucchioni, Paolo Montuschi, David Myles, E.H.D. Bel, Anna James, Elena Formaggio, Anthony Rowe, Dominic E. Shaw, J. Haughney, P. Chanez, A.R. Sousa, S.J. Fowler, K. Fichtner, B. Dahlèn
Publikováno v:
U-BIOPRED Study Group 2021, ' Medication adherence in patients with severe asthma prescribed oral corticosteroids in the U-BIOPRED cohort ', Chest . https://doi.org/10.1016/j.chest.2021.02.023
Alahmadi, Fahad H; Simpson, Andrew J; Gomez, Cristina; Ericsson, Magnus; Thörngren, John-Olof; Wheelock, Craig; Shaw, Dominic E; Fleming, Louise J; Roberts, Graham; Riley, John; Bates, Stewart; Sousa, Ana R; Knowles, Richard; Bansal, Aruna T; Corfield, Julie; Pandis, Ioannis; Sun, Kai; Bakke, Per S; Caruso, Massimo; Chanez, Pascal; ... (2021). Medication Adherence in Patients With Severe Asthma Prescribed Oral Corticosteroids in the U-BIOPRED Cohort. Chest, 160(1), pp. 53-64. Elsevier 10.1016/j.chest.2021.02.023
Chest
Chest, 2021, 160 (1), pp.53-64. ⟨10.1016/j.chest.2021.02.023⟩
Chest, 160(1), 53-64. American College of Chest Physicians
Alahmadi, Fahad H; Simpson, Andrew J; Gomez, Cristina; Ericsson, Magnus; Thörngren, John-Olof; Wheelock, Craig; Shaw, Dominic E; Fleming, Louise J; Roberts, Graham; Riley, John; Bates, Stewart; Sousa, Ana R; Knowles, Richard; Bansal, Aruna T; Corfield, Julie; Pandis, Ioannis; Sun, Kai; Bakke, Per S; Caruso, Massimo; Chanez, Pascal; ... (2021). Medication Adherence in Patients With Severe Asthma Prescribed Oral Corticosteroids in the U-BIOPRED Cohort. Chest, 160(1), pp. 53-64. Elsevier 10.1016/j.chest.2021.02.023
Chest
Chest, 2021, 160 (1), pp.53-64. ⟨10.1016/j.chest.2021.02.023⟩
Chest, 160(1), 53-64. American College of Chest Physicians
Background: Although estimates of suboptimal adherence to oral corticosteroids in asthma range from 30% to 50%, no ideal method for measurement exists; the impact of poor adherence in severe asthma is likely to be particularly high. Research Question
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::468463af63606145dd36257575147b02
http://www.scopus.com/inward/record.url?scp=85109134627&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85109134627&partnerID=8YFLogxK
Autor:
Akul Singhania, Hitasha Rupani, Nivenka Jayasekera, Simon Lumb, Paul Hales, Neil Gozzard, Donna E Davies, Christopher H Woelk, Peter H Howarth
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0168680 (2017)
Management of severe asthma remains a challenge despite treatment with glucocorticosteroid therapy. The majority of studies investigating disease mechanisms in treatment-resistant severe asthma have previously focused on the large central airways, wi
Externí odkaz:
https://doaj.org/article/dfeb7c410dfd43f6b476ae9e263705dc
Autor:
N Zounemat Kermani, G Macis, P S Bakke, M Caruso, P Chanez, R Djukanovic, S J Fowler, Y Guo, I Horvath, P H Howarth, A I Maitland-Van Der Zee, M Malerba, G Roberts, M Sanak, D Shaw, S J Wilson, S Siddiqui, S Dahlen, K F Chung, I M Adcock, P Montuschi, On Behalf Of The U-Biopred Study Group
Publikováno v:
ERS International Congress 2022
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::209abdf58a3dc30e4941413561c41d35
http://hdl.handle.net/10044/1/104553
http://hdl.handle.net/10044/1/104553
Autor:
Ana S. Francisco-Garcia, Eva M. Garrido-Martín, Hitasha Rupani, Laurie C. K. Lau, Rocio T. Martinez-Nunez, Peter H. Howarth, Tilman Sanchez-Elsner
Publikováno v:
Non-Coding RNA, Vol 5, Iss 4, p 51 (2019)
MicroRNAs are known to regulate important pathways in asthma pathology including the IL-6 and IFN pathways. MicroRNAs have been found not only within cells but also within extracellular vesicles such as exosomes. In this study, we particularly focuse
Externí odkaz:
https://doaj.org/article/6e44121955f34799bb921e957446d686