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pro vyhledávání: '"P H, Duquette"'
Publikováno v:
Chemischer Informationsdienst. 15
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 9(5)
Autor:
P H, Duquette, J L, Holtzman
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 10(3)
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 11(5)
We have modified our radiometric assay for ethylmorphine N-demethylase to examine the metabolism of codeine. We find that the current assay gives excellent separation of metabolites with a zero time activity of 0.08%. The N- and O-demethylations are
Autor:
P H, Duquette, J L, Holtzman
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 211(1)
A sensitive and convenient radioassay for the in vitro determination of ethylmorphine N-demethylase and O-de-ethylase activity has been developed. Ethylmorphine[6-3H] was prepared by reduction of the corresponding morphinone in nearly quantitative yi