Zobrazeno 1 - 10
of 88
pro vyhledávání: '"P H, Bolton"'
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e96218 (2014)
Structural information on the complexes of drug like molecules with quadruplex DNAs can aid the development of therapeutics and research tools that selectively target specific quadruplex DNAs. Screening can identify candidate molecules that require a
Externí odkaz:
https://doaj.org/article/f7d19b4a39174efab4aef59d079343e4
Autor:
C. A. Hart, Cheng Hock Toh, I. T. Gilmore, R. U. Khan, C. Y. W. Tong, P. H. Bolton-Maggs, S. Bloom, Nicholas J. Beeching
Publikováno v:
Journal of Medical Virology. 52:35-41
A number of different approaches have been used for genotyping hepatitis C virus (HCV). Two simplified methods were evaluated, both of which used polymerase chain reaction (PCR) to amplify products from the 5' non-coding region of HCV: non-isotopic r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2863c09787c27f30a1750447896536d5
https://doi.org/10.1002/(sici)1096-9071(199705)52:1<35::aid-jmv7>3.0.co
https://doi.org/10.1002/(sici)1096-9071(199705)52:1<35::aid-jmv7>3.0.co
Publikováno v:
Haemophilia : the official journal of the World Federation of Hemophilia. 6(2)
A 12-year-old boy presented with a traumatic hyphaema that failed to settle with the standard treatment. Subsequent investigation showed that despite a normal APTT, he had a low factor VIII:C. Treatment with DDAVP precipitated further bleeding despit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a9aeebd416f2eac48882f4058e44d95d
https://pubmed.ncbi.nlm.nih.gov/10781201
https://pubmed.ncbi.nlm.nih.gov/10781201
Autor:
P H, Bolton-Maggs
Publikováno v:
Haemophilia : the official journal of the World Federation of Hemophilia. 5(3)
Factor XI deficiency affects both sexes. Some bleeding problems are specific to women, and have been overlooked in the past. Women with factor XI deficiency are prone to menorrhagia and to bleeding complications after childbirth. These may occur in w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1fb4d607404a093542f2cfeaa2aa91fd
https://pubmed.ncbi.nlm.nih.gov/10444281
https://pubmed.ncbi.nlm.nih.gov/10444281
Autor:
V M, Marathias, P H, Bolton
Publikováno v:
Biochemistry. 38(14)
There are DNA sequences which adopt the same quadruplex structural type in the presence of sodium as in the presence of sodium and potassium. There are also sequences that appear to have a requirement for the presence of potassium for the adoption of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::05ba0e7e54f7e481fa4740758ac746f8
https://pubmed.ncbi.nlm.nih.gov/10194354
https://pubmed.ncbi.nlm.nih.gov/10194354
Autor:
R D, Beger, P H, Bolton
Publikováno v:
Journal of biomolecular NMR. 10(2)
The chemical shifts of the backbone atoms of proteins can be used to obtain restraints that can be incorporated into structure determination methods. Each chemical shift can be used to define a restraint and these restraints can be simultaneously use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6c4d502db0cda20b9bcb5b318f0c6add
https://pubmed.ncbi.nlm.nih.gov/9369014
https://pubmed.ncbi.nlm.nih.gov/9369014
Publikováno v:
The Journal of biological chemistry. 272(34)
Bacteriophage PBS2 uracil-DNA glycosylase inhibitor (Ugi) protein inactivates uracil-DNA glycosylase (Ung) by acting as a DNA mimic to bind Ung in an irreversible complex. Seven mutant Ugi proteins (E20I, E27A, E28L, E30L, E31L, D61G, and E78V) were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::df8d4d0f6f7ea87547100b3752f12d3b
https://pubmed.ncbi.nlm.nih.gov/9261156
https://pubmed.ncbi.nlm.nih.gov/9261156
Autor:
R U, Khan, C Y, Tong, S, Bloom, I T, Gilmore, C H, Toh, P H, Bolton-Maggs, N J, Beeching, C A, Hart
Publikováno v:
Journal of medical virology. 52(1)
A number of different approaches have been used for genotyping hepatitis C virus (HCV). Two simplified methods were evaluated, both of which used polymerase chain reaction (PCR) to amplify products from the 5' non-coding region of HCV: non-isotopic r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::68cf098429268809b4f6fd4751bfcd8c
https://pubmed.ncbi.nlm.nih.gov/9131456
https://pubmed.ncbi.nlm.nih.gov/9131456
Autor:
P H, Bolton-Maggs
Publikováno v:
Bailliere's clinical haematology. 9(2)
That factor XI has a role in normal blood coagulation is evidenced by the fact that patients with deficiency are prone to excessive bleeding after haemostatic challenge. The role of factor XI in physiological processes has become clearer since the di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b17603fd7e2c44e78492bf036f156b11
https://pubmed.ncbi.nlm.nih.gov/8800510
https://pubmed.ncbi.nlm.nih.gov/8800510
Definition of the bleeding tendency in factor XI-deficient kindreds--a clinical and laboratory study
Publikováno v:
Thrombosis and haemostasis. 73(2)
Individuals with severe factor XI deficiency are prone to excessive bleeding after injury or surgery, but the existence of a haemorrhagic tendency in partial factor XI deficiency is controversial. In this study, 172 members of 30 kindreds (20 non-Jew
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3027c125a596ad3129851fbc0563b80d
https://pubmed.ncbi.nlm.nih.gov/7792729
https://pubmed.ncbi.nlm.nih.gov/7792729