Zobrazeno 1 - 10
of 122
pro vyhledávání: '"P Grailhe"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract In vivo fluorescent imaging represents a potent means for real-time probe quantification, facilitating insights into disease pathophysiology and therapeutic responses. Nonetheless, accurate signal quantification remains challenging due to in
Externí odkaz:
https://doaj.org/article/5090790d1995473fba36a9611fcdc0e0
Autor:
Stephane Illiano, Bruno Poirier, Claire Minoletti, Olivier Pasquier, Laurence Riva, Xavier Chenede, Isabelle Menguy, Michel Guillotel, Philippe Prigent, Stéphane Le Claire, Florence Gillot, Gilbert Thill, François Lo Presti, Alain Corbier, Jean-Christophe Le Bail, Patrick Grailhe, Edith Monteagudo, Raffaele Ingenito, Elisabetta Bianchi, Christophe Philippo, Olivier Duclos, Sergio Mallart, Ross Bathgate, Philip Janiak
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Despite beneficial effects in acute heart failure, the full therapeutic potential of recombinant relaxin-2 has been hampered by its short half-life and the need for intravenous administration limiting its use to intensive care units. A multi
Externí odkaz:
https://doaj.org/article/9680bc4f067244f5859525deb060514b
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Bioluminescence resonance energy transfer (BRET) saturation is a method of studying protein–protein interaction (PPI) upon quantification of the dependence of the BRET signal on the acceptor/donor (A:D) expression ratio. In this study, usi
Externí odkaz:
https://doaj.org/article/ff33b828cc32409194b9af61c58a9767
Autor:
Nasia Antoniou, Kanella Prodromidou, Georgia Kouroupi, Ioanna Boumpoureka, Martina Samiotaki, George Panayotou, Maria Xilouri, Ismini Kloukina, Leonidas Stefanis, Regis Grailhe, Era Taoufik, Rebecca Matsas
Publikováno v:
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-18 (2022)
Abstract Combining high throughput screening approaches with induced pluripotent stem cell (iPSC)-based disease modeling represents a promising unbiased strategy to identify therapies for neurodegenerative disorders. Here we applied high content imag
Externí odkaz:
https://doaj.org/article/cea8d1232e85465989ceec532c924bc4
Publikováno v:
FEBS Open Bio, Vol 10, Iss 10, Pp 2010-2020 (2020)
Sphingosine‐1 phosphate receptor‐1 (S1P1) activation maintains endothelial barrier integrity, whereas S1P1 desensitization induces peripheral blood lymphopenia. The latter is exploited in the approval and/or late‐stage development of receptor
Externí odkaz:
https://doaj.org/article/e022a51d0677491c9f42e7504f1fb2ef
Autor:
Seonhee Kim, Florence Larrous, Hugo Varet, Rachel Legendre, Lena Feige, Guillaume Dumas, Rebecca Matsas, Georgia Kouroupi, Regis Grailhe, Hervé Bourhy
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Rabies is a zoonotic disease caused by rabies virus (RABV). As rabies advances, patients develop a variety of severe neurological symptoms that inevitably lead to coma and death. Unlike other neurotropic viruses that can induce symptoms of a similar
Externí odkaz:
https://doaj.org/article/a2e35cdb9eea4115b287e61bb2cb68e7
Autor:
Sungsu Lim, Dohee Kim, Shinyeong Ju, Seulgi Shin, Il-joo Cho, Sung-Hye Park, Regis Grailhe, Cheolju Lee, Yun Kyung Kim
Publikováno v:
Experimental and Molecular Medicine, Vol 50, Iss 4, Pp 1-11 (2018)
Brain tumors: Protein prompt for brain degeneration A protein secreted by aggressive brain tumors triggers the degeneration of neurons in surrounding brain tissues. The most aggressive brain tumors are formed by glioblastoma cells, which secrete mole
Externí odkaz:
https://doaj.org/article/f68afc42ed3a4a71b9d51ecb096bae46
Autor:
Benoit Besson, Seonhee Kim, Taehee Kim, Yoonae Ko, Sangchul Lee, Florence Larrous, Jihwan Song, David Shum, Regis Grailhe, Hervé Bourhy
Publikováno v:
mSphere, Vol 4, Iss 3 (2019)
ABSTRACT Throughout the rabies virus (RABV) infectious cycle, host-virus interactions define its capacity to replicate, escape the immune response, and spread. As phosphorylation is a key regulatory mechanism involved in most cellular processes, kina
Externí odkaz:
https://doaj.org/article/160599d909b84cd9b8cf564030d9e9b1
Akademický článek
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Autor:
Benoit Besson, Florian Sonthonnax, Magalie Duchateau, Youcef Ben Khalifa, Florence Larrous, Hyeju Eun, Véronique Hourdel, Mariette Matondo, Julia Chamot-Rooke, Regis Grailhe, Hervé Bourhy
Publikováno v:
PLoS Pathogens, Vol 13, Iss 10, p e1006697 (2017)
At the crossroad between the NF-κB and the MAPK pathways, the ternary complex composed of p105, ABIN2 and TPL2 is essential for the host cell response to pathogens. The matrix protein (M) of field isolates of rabies virus was previously shown to dis
Externí odkaz:
https://doaj.org/article/6c9bd4d60c9b4f46a05a38dfd774dc6a