Zobrazeno 1 - 10
of 15
pro vyhledávání: '"P G Waber"'
Publikováno v:
Oncogene. 12(2)
Previous molecular genetic studies revealed that allelic loss of chromosome arm 3p is a frequent event in upper aerodigestive tract squamous cell carcinoma (UADT SCC). Recently, the Von-Hippel Lindau (VHL) tumor suppressor gene was identified at chro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a42014c27698679ac286ee25cb6dfba8
https://pubmed.ncbi.nlm.nih.gov/8570213
https://pubmed.ncbi.nlm.nih.gov/8570213
Publikováno v:
Cancer. 75(6)
In human brain tumors, sensitivity to procarbazine as measured by sensitivity in a xenograft tumor model correlated inversely with amounts of the DNA repair enzyme O6-alkylguanine DNA alkyltransferase (AT).To test the hypothesis that mutations of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::243002198977b15f728e04f9042210b5
https://pubmed.ncbi.nlm.nih.gov/7882284
https://pubmed.ncbi.nlm.nih.gov/7882284
Publikováno v:
Journal of the National Cancer Institute. 86(20)
Little is known about the molecular genetic events that contribute to the pathogenesis of squamous cell carcinoma of the upper aerodigestive tract. Previous molecular genetic studies have been limited to the identification of mutations of the p53 (al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::074fcd8b0a8670798be80e3baae87469
https://pubmed.ncbi.nlm.nih.gov/7932807
https://pubmed.ncbi.nlm.nih.gov/7932807
Publikováno v:
Cancer research. 53(24)
Loss of function of the p53 tumor suppressor gene by point mutation is the most commonly detected genetic alteration in human cancer. There is growing evidence that amplification and overexpression of the MDM2 gene are alternative mechanisms that als
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::95b190922c762780b4d68e762f05de66
https://pubmed.ncbi.nlm.nih.gov/8261417
https://pubmed.ncbi.nlm.nih.gov/8261417
Publikováno v:
Cancer. 72(12)
Alteration of the ras family of oncogenes and of the tumor suppressor genes p53 and RB are the most common genetic events in human tumors. Although there have been no reports of the prevalence of these alterations in Wilms tumors, overexpression of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6e01c21c73446dd8d73406f842495104
https://pubmed.ncbi.nlm.nih.gov/8252491
https://pubmed.ncbi.nlm.nih.gov/8252491
Publikováno v:
Blood. 67:1185-1188
Analysis of restriction site polymorphisms in the beta-globin gene cluster of a Saudi Arabian female with beta zero-thalassemia demonstrated that both of her beta-globin genes were missing a nonpolymorphic AvaII site in exon 2. Examination of the nor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71342897cd17bd8de6969ea96f56cd39
https://doi.org/10.1182/blood.v67.4.1185.1185
https://doi.org/10.1182/blood.v67.4.1185.1185
Autor:
P G Waber, Richard E. Gelinas, Bernard G. Forget, Francis S. Collins, Aris Karaklis, Michael A. Bender, Haig H. Kazazian, George Stamatoyannopoulos, Christos Kattamis, Koula Sofroniadou
Publikováno v:
Blood. 67:551-554
In the Greek A gamma beta + type of hereditary persistence of fetal hemoglobin (HPFH), adult heterozygotes produce about 20% fetal hemoglobin (HbF), which is predominantly of the A gamma chain variety. The affected beta-globin gene cluster produces n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43384bd513af9f66ff760c012d288488
https://doi.org/10.1182/blood.v67.2.551.551
https://doi.org/10.1182/blood.v67.2.551.551
Autor:
HH Jr Kazazian, Stylianos E. Antonarakis, Eric R. Fearon, Paula S. Henthorn, Elio F. Vanin, Frank Grosveld, Stuart H. Orkin, Alan F. Scott, George R. Buchanan, P G Waber, Ji Lee
Publikováno v:
Blood. 61:1269-1274
We have used restriction endonuclease mapping to study a deletion involving the beta-globin gene cluster in a Mexican-American family with gamma delta beta-thalassemia. Analysis of DNA polymorphisms demonstrated deletion of the beta-globin gene from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::125fceb8df027565f17a0259f3ca2a0d
https://doi.org/10.1182/blood.v61.6.1269.1269
https://doi.org/10.1182/blood.v61.6.1269.1269
Publikováno v:
Blood. 68:964-966
To make possible prenatal diagnosis of beta-thalassemia in China and Southeast Asia by direct detection of mutant beta-globin genes, we have determined the spectrum of mutations producing the disorder in this region of the world. Seventy-eight beta-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::034a49a331ecd119fdc667b33e1714b4
https://doi.org/10.1182/blood.v68.4.964.bloodjournal684964
https://doi.org/10.1182/blood.v68.4.964.bloodjournal684964
Autor:
H H, Kazazian, C E, Dowling, P G, Waber, S Z, Huang, W H, Lo, A, Li, J W, Tam, J, Kang, S E, Antonarakis
Publikováno v:
Progress in clinical and biological research. 251
We have studied the spectrum of mutations producing beta-thalassemia (beta-thal) in South China and Southeast Asia in two groups of patients. In randomly selected patients with beta-thal major we characterized 78 beta-thal genes. In patients with bet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c1d4584dff6193e9e32b39dc12f9c8e8
https://pubmed.ncbi.nlm.nih.gov/3432272
https://pubmed.ncbi.nlm.nih.gov/3432272