Zobrazeno 1 - 10
of 134
pro vyhledávání: '"P G Horgan"'
Autor:
Allan M. Golder, Michael Ferguson, Paul McMillan, David Mansouri, Paul G. Horgan, Campbell S. Roxburgh, Ross D. Dolan, Josh McGovern, Donald C. McMillan
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Low skeletal muscle index/density (SMI/SMD) is prevalent in cancer, adversely prognostic and associated with tumour stage and the systemic inflammatory response (SIR). Age and SMI/SMD has not been widely studied. The present study analyses t
Externí odkaz:
https://doaj.org/article/7738b8cc6df943eaa536a0fe19246477
Autor:
Norman J. Galbraith, Jean A. Quinn, Sara Sf Al-Badran, Kathryn A.F. Pennel, Lily V.S. Hillson, Phimmada Hatthakarnkul, Molly McKenzie, Noori Maka, Lynette Loi, Mikaela Frixou, Colin W. Steele, Campbell S. Roxburgh, Paul G. Horgan, Donald C. McMillan, Joanne Edwards
Publikováno v:
Translational Oncology, Vol 48, Iss , Pp 102064- (2024)
Background: Transforming growth factor β-activated protein kinase-1 (TAK1) plays an important role in MAPK and NFκB pathways and has been associated with colorectal cancer. The aim of this study was to determine how cytoplasmic and juxtanuclear pun
Externí odkaz:
https://doaj.org/article/f77b384652bb4325a5076d3ce2c361b8
Publikováno v:
Biochemistry and Biophysics Reports, Vol 39, Iss , Pp 101810- (2024)
Alpha-synuclein (α-syn) aggregation plays a critical role in the pathogenicity of Parkinson's Disease (PD). This study aims to evaluate the aggregation propensity of α-syn fragment peptides designed using the variability found in humans and animals
Externí odkaz:
https://doaj.org/article/26834cd41672433e9d1c10ef63c1e9d2
Autor:
Katharina Meredith, John G. Horgan
Publikováno v:
Journal for Deradicalization, Vol Spring 2024, Iss 38, Pp 165-210 (2024)
This exploratory study provides foundational knowledge on the post-exit process experienced by former members of violent extremist groups. While disengagement from violent extremism and the transition to mainstream society is known to involve change
Externí odkaz:
https://doaj.org/article/12258f97d6cc4590ae82ea36b7ac2b0f
Autor:
Kathryn A. F. Pennel, Phimmada Hatthakarnkul, Colin S. Wood, Guang-Yu Lian, Sara S. F. Al-Badran, Jean A. Quinn, Assya Legrini, Jitwadee Inthagard, Peter G. Alexander, Hester van Wyk, Ahmad Kurniawan, Umar Hashmi, Michael A. Gillespie, Megan Mills, Aula Ammar, Jennifer Hay, Ditte Andersen, Colin Nixon, Selma Rebus, David K. Chang, Caroline Kelly, Andrea Harkin, Janet Graham, David Church, Ian Tomlinson, Mark Saunders, Tim Iveson, Tamsin R. M. Lannagan, Rene Jackstadt, Noori Maka, Paul G. Horgan, Campbell S. D. Roxburgh, Owen J. Sansom, Donald C. McMillan, Colin W. Steele, Nigel B. Jamieson, James H. Park, Antonia K. Roseweir, Joanne Edwards
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-20 (2024)
Abstract Colorectal cancer (CRC) is a heterogenous malignancy underpinned by dysregulation of cellular signaling pathways. Previous literature has implicated aberrant JAK/STAT3 signal transduction in the development and progression of solid tumors. I
Externí odkaz:
https://doaj.org/article/3b63169b435447a19a5fb490ee037279
Autor:
Josh McGovern, Charles Mackay, Rhiannon Freireich, Allan M. Golder, Ross D. Dolan, Paul G. Horgan, David Holroyd, Nigel B. Jamieson, Donald C. McMillan
Publikováno v:
Tomography, Vol 10, Iss 3, Pp 349-359 (2024)
Introduction: The prognostic value of CT-derived liver volume in terms of cancer outcomes is not clear. The aim of the present study was to examine the relationship between liver area on a single axial CT-slice and the total liver volume in patients
Externí odkaz:
https://doaj.org/article/517953092bdb4749bad6d194579ffdb4
Autor:
Diego Portalanza, Malena Torres, Flavia Rosso, Cristian Felipe Zuluaga, Angelica Durigon, Finbarr G. Horgan, Eduardo Alava, Simone Ferraz
Publikováno v:
Frontiers in Climate, Vol 6 (2024)
Ecuador, a country with distinct coastal (CO), highland (HL), and Amazon (AM) regions that are characterized by unique climatic, ecological, and socio-economic features is highly vulnerable to climate change. This study focuses on these three regions
Externí odkaz:
https://doaj.org/article/859059d8f7014dad919000044bad9cab
Autor:
Jorge Ari Noriega, Joaquín Hortal, Indradatta deCastro-Arrazola, Fernanda Alves-Martins, Jean C. G. Ortega, Luis Mauricio Bini, Nigel R. Andrew, Lucrecia Arellano, Sarah Beynon, Adrian L. V. Davis, Mario E. Favila, Kevin D. Floate, Finbarr G. Horgan, Rosa Menéndez, Tanja Milotic, Beatrice Nervo, Claudia Palestrini, Antonio Rolando, Clarke H. Scholtz, Yakup Senyüz, Thomas Wassmer, Réka Ádam, Cristina de O. Araújo, José Luis Barragan-Ramírez, Gergely Boros, Edgar Camero-Rubio, Melvin Cruz, Eva Cuesta, Miryam Pieri Damborsky, Christian M. Deschodt, Priyadarsanan Dharma Rajan, Bram D’hondt, Alfonso Díaz Rojas, Kemal Dindar, Federico Escobar, Verónica R. Espinoza, José Rafael Ferrer-Paris, Pablo Enrique Gutiérrez Rojas, Zac Hemmings, Benjamín Hernández, Sarah J. Hill, Maurice Hoffmann, Pierre Jay-Robert, Kyle Lewis, Megan Lewis, Cecilia Lozano, Diego Marín-Armijos, Patrícia Menegaz de Farias, Betselene Murcia-Ordoñez, Seena Narayanan Karimbumkara, José Luis Navarrete-Heredia, Candelaria Ortega-Echeverría, José D. Pablo-Cea, William Perrin, Marcelo Bruno Pessoa, Anu Radhakrishnan, Iraj Rahimi, Amalia Teresa Raimundo, Diana Catalina Ramos, Ramón E. Rebolledo, Angela Roggero, Ada Sánchez-Mercado, László Somay, Jutta Stadler, Pejman Tahmasebi, José Darwin Triana Céspedes, Ana M. C. Santos
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Dung removal by macrofauna such as dung beetles is an important process for nutrient cycling in pasturelands. Intensification of farming practices generally reduces species and functional diversity of terrestrial invertebrates, which may neg
Externí odkaz:
https://doaj.org/article/c21370c1df1b44a6b147d1e25a0c34e7
Publikováno v:
Veterinary Quarterly, Vol 43, Iss 1, Pp 1-8 (2023)
AbstractAA amyloidosis, characterized by the misfolding of serum amyloid A (SAA) protein, is the most common amyloid protein disorder across multiple species. SAA is a positive-acute phase protein synthesized by the liver in response to inflammation
Externí odkaz:
https://doaj.org/article/081be04c4b1c4c4d8387b2e68ff7a314
Publikováno v:
Veterinary Quarterly, Vol 43, Iss 1, Pp 1-12 (2023)
AbstractBackground Type 2 diabetes (T2D) is a health concern for both humans and cats, with cases rising over the past decade. Around 70% of patients from either species exhibit pancreatic aggregates of islet amyloid polypeptide (IAPP), a protein tha
Externí odkaz:
https://doaj.org/article/c57fda51c48648fdb1583a23a34ac368