Zobrazeno 1 - 10
of 13
pro vyhledávání: '"P G Coin"'
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 16:283-292
Enhanced proliferation of fibroblasts is a primary characteristic of lung fibrosis. Macrophage-secreted platelet-derived growth factor (PDGF) is a potent mitogen and chemoattractant for lung fibroblasts. The magnitude of the fibroblast PDGF response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::245bd4bbfa94d24e1c75abf221ee3fdb
https://doi.org/10.1165/ajrcmb.16.3.9070613
https://doi.org/10.1165/ajrcmb.16.3.9070613
Autor:
James C. Bonner, Alvaro Osornio-Vargas, P. M. Lindroos, P. G. Coin, N. A. Hernandez-Rodriguez, A. Badgett
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 271:L93-L99
Alteration of the platelet-derived growth factor (PDGF) receptor system could be important in enhancing the mitogenic and chemotactic potential of lung fibroblasts during pulmonary fibrogenesis. We previously reported that interleukin-1 beta (IL-1 be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85f6c9caaef5aface187089d4172c0a2
https://doi.org/10.1152/ajplung.1996.271.1.l93
https://doi.org/10.1152/ajplung.1996.271.1.l93
Publikováno v:
The Journal of Immunology. 156:4797-4806
Differential expression of PDGF receptor alpha and beta subunits controls the response of mesenchymal cells to the three PDGF isoforms (AA, AB, and BB). Cultured rat lung myofibroblasts (RLMF) possess abundant PDGF receptor-beta (PDGF-Rbeta) and litt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49f6dc40c5f7792cc060ca456e1e0c6c
https://doi.org/10.4049/jimmunol.156.12.4797
https://doi.org/10.4049/jimmunol.156.12.4797
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 13:455-465
Fibroblasts are the primary proliferating cell type in pulmonary fibrosis. We previously showed that inorganic, fibrogenic particles alter the platelet-derived growth factor (PDGF) receptor system on rat lung fibroblasts (Bonner, J. C., et al. 1993,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d928495447e1ce2cf0b252466f64260e
https://doi.org/10.1165/ajrcmb.13.4.7546776
https://doi.org/10.1165/ajrcmb.13.4.7546776
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 12:162-170
We have investigated the mitogenic and chemotactic role of platelet-derived growth factor (PDGF) in pulmonary fibrogenesis induced by chrysotile asbestos. Since fibroblasts phagocytize asbestos in the lung interstitium, we have sought to learn whethe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08575c203220c01c3d4d21a0ce568ea7
https://doi.org/10.1165/ajrcmb.12.2.7865215
https://doi.org/10.1165/ajrcmb.12.2.7865215
Publikováno v:
Environmental Research. 58:97-116
We investigated the pulmonary deposition, clearance, and translocation of chrysotile asbestos in the context of our previously developed model of asbestosis in the rat. Adult male rats were exposed for 3 hr to an aerosol of chrysotile asbestos. Subgr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88e459317faa9d8ce7327c6b270c0f30
https://doi.org/10.1016/s0013-9351(05)80207-5
https://doi.org/10.1016/s0013-9351(05)80207-5
Autor:
P G Coin, Victor L. Roggli
Publikováno v:
Pathology of Asbestos-Associated Diseases ISBN: 0387200908
The term asbestos refers to a group of mineral fibers that share the properties of thermal and chemical resistance, flexibility, and high tensile strength. The word derives from the Greek sasbestos, signifying “unquenchable” or “indestructible.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7ec9760440b281518b4b5bf047155ee
https://doi.org/10.1007/0-387-21819-x_1
https://doi.org/10.1007/0-387-21819-x_1
Publikováno v:
The American journal of physiology. 271(6 Pt 1)
Bronchial smooth muscle cell (SMC) hyperplasia is a key feature in the pathology of asthma. Platelet-derived growth factor (PDGF) isoforms are SMC mitogens. We investigated the effect of basic fibroblast growth factor (bFGF), transforming growth fact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce43ec1637e6d6a858f854c28b5125e9
https://pubmed.ncbi.nlm.nih.gov/8997257
https://pubmed.ncbi.nlm.nih.gov/8997257
Publikováno v:
American journal of respiratory and critical care medicine. 154(5)
Previously, this laboratory developed a model of asbestos-induced pulmonary fibrogenesis in rats and mice after a brief (1 to 3-h) inhalation exposure. However, typical human environmental exposures would be repeated, although at lower concentrations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2e0799576d19b536dc4913014d08a58
https://pubmed.ncbi.nlm.nih.gov/8912773
https://pubmed.ncbi.nlm.nih.gov/8912773
Autor:
Arnold R. Brody, P G Coin, A L Goodell, Annette Badgett, Alvaro Osornio-Vargas, James C. Bonner, N. A. Hernandez-Rodriguez
Publikováno v:
Scopus-Elsevier
Platelet-derived growth factor (PDGF) isoforms are chemoattractants and mitogens for cells of mesenchymal origin that could be important mediators of pulmonary fibrogenesis. We have previously reported that particle-activated alveolar macrophages sec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53634205ac47ad4fb2a04fa588817077
https://pubmed.ncbi.nlm.nih.gov/7811469
https://pubmed.ncbi.nlm.nih.gov/7811469