Zobrazeno 1 - 10
of 1 304
pro vyhledávání: '"P G, Rees"'
Group 3 medulloblastoma transcriptional networks collapse under domain specific EP300/CBP inhibition
Autor:
Noha A. M. Shendy, Melissa Bikowitz, Logan H. Sigua, Yang Zhang, Audrey Mercier, Yousef Khashana, Stephanie Nance, Qi Liu, Ian M. Delahunty, Sarah Robinson, Vanshita Goel, Matthew G. Rees, Melissa A. Ronan, Tingjian Wang, Mustafa Kocak, Jennifer A. Roth, Yingzhe Wang, Burgess B. Freeman, Brent A. Orr, Brian J. Abraham, Martine F. Roussel, Ernst Schonbrunn, Jun Qi, Adam D. Durbin
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Chemical discovery efforts commonly target individual protein domains. Many proteins, including the EP300/CBP histone acetyltransferases (HATs), contain several targetable domains. EP300/CBP are critical gene-regulatory targets in cancer, wi
Externí odkaz:
https://doaj.org/article/398968e4bfb8412fb2122ae3a754c4c5
Autor:
Venu Thatikonda, Verena Supper, Johannes Wachter, Onur Kaya, Anju Kombara, Ceren Bilgilier, Madhwesh C. Ravichandran, Jesse J. Lipp, Rahul Sharma, Lukas Badertscher, Andrew S. Boghossian, Matthew G. Rees, Melissa M. Ronan, Jennifer A. Roth, Sarah Grosche, Ralph A. Neumüller, Barbara Mair, Federico Mauri, Alexandra Popa
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114175- (2024)
Summary: Transcription factors (TFs) are important mediators of aberrant transcriptional programs in cancer cells. In this study, we focus on TF activity (TFa) as a biomarker for cell-line-selective anti-proliferative effects, in that high TFa predic
Externí odkaz:
https://doaj.org/article/cf2194b70a344373b2d1a869bceef1a4
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
IntroductionSkull density ratio (SDR) is the ratio between the mean Hounsfield units of marrow and cortical bone, impacting energy transmission through the skull. Low SDR has been used as an exclusion criterion in major trials of magnetic resonance-g
Externí odkaz:
https://doaj.org/article/6185dd940d00490d9998f1e73e45a46b
Neurosurgery targets in the thalamus can be challenging to identify during transcranial MRI-guided focused ultrasound (MRgFUS) thermal ablation due to poor image quality. They also neighbor structures that can result in side effects if damaged. Here
Externí odkaz:
http://arxiv.org/abs/2005.11183
Publikováno v:
Brain Stimulation, Vol 16, Iss 3, Pp 806-814 (2023)
Background: MR-guided focused ultrasound is a promising intervention for treatment-resistant mental illness, and merits contextualized ethical exploration in relation to more extensive ethical literature regarding other psychosurgical and neuromodula
Externí odkaz:
https://doaj.org/article/b79a4037b6e3483b880a032c579ccfb2
Autor:
Wei Qiu, Qi Sun, Yi Yang, Chirag Patel, Meng Sun, Yue Liu, Kyle Halliwill, Sarah Kim, Rebecca Mathew, Jennifer M Frost, Jennifer A Roth, Domenick Kennedy, Robert T Manguso, Kathleen B Yates, Hakimeh Ebrahimi-Nik, Christina K Baumgartner, Arvin Iracheta-Vellve, Keith M Hamel, Kira Olander, Thomas GR Davis, Kathleen A McGuire, Geoff T Halvorsen, Omar I Avila, Ashwin V Kammula, Audrey J Muscato, Prasanthi Geda, Kelly Klinge, Zhaoming Xiong, Ryan Duggan, Liang Mu, Mitchell D Yeary, James C Patti, Tyler M Balon, Carey Backus, Angeline Chen, Kenton Longenecker, Joseph Klahn, Cara Hrusch, Navasona Krishnan, Charles W Hutchins, Jacqueline Aguado, Marinka Bulic, Payal Tiwari, Kayla J Colvin, Cun Lan Chuong, Ian C Kohnle, Matthew G Rees, Andrew Boghossian, Melissa Ronan, Meng-Ju Wu, Debattama R Sen, Gabriel K Griffin, Nabeel El-Bardeesy, Patricia Trusk, Joshua H Decker, Stacey Fossey, Marcia N Paddock, Elliot P Farney, Clay Beauregard, Philip R Kym
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 2 (2023)
Externí odkaz:
https://doaj.org/article/11356ff1bf1f4b63ab1324cafa253315
Autor:
Fangyun Tian, Laura D. Lewis, David W. Zhou, Gustavo A. Balanza, Angelique C. Paulk, Rina Zelmann, Noam Peled, Daniel Soper, Laura A. Santa Cruz Mercado, Robert A. Peterfreund, Linda S. Aglio, Emad N. Eskandar, G. Rees Cosgrove, Ziv M. Williams, R. Mark Richardson, Emery N. Brown, Oluwaseun Akeju, Sydney S. Cash, Patrick L. Purdon
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
The neural mechanisms underpinning ketamine’s dissociative and antidepressant effects remain poorly understood. Here, the authors analyzed ketamine-induced brain dynamics with intracranial recordings in humans and found that ketamine engages differ
Externí odkaz:
https://doaj.org/article/da8d61cabb16496a94d360fce79c2d24
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