Zobrazeno 1 - 10
of 211
pro vyhledávání: '"P G, Lewis"'
Variant-proof high affinity ACE2 antagonist limits SARS-CoV-2 replication in upper and lower airways
Autor:
Matthew Gagne, Barbara J. Flynn, Christopher Cole Honeycutt, Dillon R. Flebbe, Shayne F. Andrew, Samantha J. Provost, Lauren McCormick, Alex Van Ry, Elizabeth McCarthy, John-Paul M. Todd, Saran Bao, I-Ting Teng, Shir Marciano, Yinon Rudich, Chunlin Li, Shilpi Jain, Bushra Wali, Laurent Pessaint, Alan Dodson, Anthony Cook, Mark G. Lewis, Hanne Andersen, Jiří Zahradník, Mehul S. Suthar, Martha C. Nason, Kathryn E. Foulds, Peter D. Kwong, Mario Roederer, Gideon Schreiber, Robert A. Seder, Daniel C. Douek
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract SARS-CoV-2 has the capacity to evolve mutations that escape vaccine- and infection-acquired immunity and antiviral drugs. A variant-agnostic therapeutic agent that protects against severe disease without putting selective pressure on the vir
Externí odkaz:
https://doaj.org/article/398a2dfd9ac6483f881f1a81f6f17840
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Depression is the leading cause of disability worldwide, exerting a profound negative impact on quality of life in those who experience it. Depression is associated with disruptions to several closely related neural and cognitive processes,
Externí odkaz:
https://doaj.org/article/01efcb42aa4a4d0994af5499670aff5f
Autor:
Jasmin Galper, Giorgia Mori, Gordon McDonald, Diba Ahmadi Rastegar, Russell Pickford, Simon J. G. Lewis, Glenda M. Halliday, Woojin S. Kim, Nicolas Dzamko
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-9 (2024)
Abstract Identifying biological factors which contribute to the clinical progression of heterogeneous motor and non-motor phenotypes in Parkinson’s disease may help to better understand the disease process. Several lipid-related genetic risk factor
Externí odkaz:
https://doaj.org/article/d5f223abd06a454fa2a51735d65b6a53
Autor:
Philip A Wheeler, Nicholas S West, Richard Powis, Rhydian Maggs, Michael Chu, Rachel A Pearson, Nick Willis, Bartlomiej Kurec, Katie L. Reed, David G. Lewis, John Staffurth, Emiliano Spezi, Anthony E. Millin
Publikováno v:
Radiation Oncology, Vol 19, Iss 1, Pp 1-11 (2024)
Abstract Background Current automated planning solutions are calibrated using trial and error or machine learning on historical datasets. Neither method allows for the intuitive exploration of differing trade-off options during calibration, which may
Externí odkaz:
https://doaj.org/article/e896d6b30ee2484b927251cdf6a63ef2
Autor:
Jeremy R. Smith, Christine D. Sislak, Pedro Fernandez Mendoza, Laurin Carmichael, Alisha G. Lewis, Anqi Chen, Glycine Z. Jiang, Patrick A. Gibney
Publikováno v:
Applied Microbiology, Vol 4, Iss 1, Pp 453-469 (2024)
Plasmid shuttle vectors are a common tool used to study yeast physiology. The majority of yeast plasmids have been optimized for Saccharomyces cerevisiae lab strain compatibility, relying on auxotrophic complementation as their selective property. We
Externí odkaz:
https://doaj.org/article/70b32ec0bf7c4077a8770a29391608a6
Publikováno v:
Frontiers in Environmental Archaeology, Vol 3 (2024)
Fire is a key disturbance process that shapes the structure and function of montane temperate rainforest in the Pacific Northwest (PNW). Recent research is revealing more frequent historical fire activity in the western central Cascades than expected
Externí odkaz:
https://doaj.org/article/9f1c138c046c434894a42ccd9e8a0605
Autor:
Tippawan Liabsuetrakul, Soo Downe, Ioannis Gallos, Fernando Althabe, Olufemi T Oladapo, Alexandre Dumont, Arri Coomarasamy, Inês Nunes, Edgardo Abalos, Pisake Lumbiganon, Zahida P Qureshi, María Fernanda Escobar, Sue Fawcus, Elliott K Main, John Varallo, G Justus Hofmeyr, Judith Maua, Catherine Deneux-Tharaux, Andrew D Weeks, Caroline Homer, Brendan Carvalho, Sabaratnam Arulkumaran, Mariana Widmer, Veronica Pingray, Fadhlun M Alwy Al-Beity, Ashraf Fawzy Nabhan, Claudio Sosa, Caitlin R Williams, Alejandro Blumenfeld, Cherrie Evans, Hadiza S Galadanci, Diem-Tuyet Thi Hoang, Ayodele G Lewis, Francis G Muriithi, Vanesa Ortega, Thuan N Q Phan, Suellen Miller
Publikováno v:
BMJ Open, Vol 14, Iss 5 (2024)
Objective There are no globally agreed on strategies on early detection and first response management of postpartum haemorrhage (PPH) during and after caesarean birth. Our study aimed to develop an international expert’s consensus on evidence-based
Externí odkaz:
https://doaj.org/article/e7ee6454eba440898a3819dad0cfa8c0
Publikováno v:
Sensors, Vol 24, Iss 18, p 6019 (2024)
Peatlands across the world are vital carbon stores. However, human activities have caused the degradation of many sites, increasing their greenhouse gas emissions and vulnerability to wildfires. Comprehensive monitoring of peatlands is essential for
Externí odkaz:
https://doaj.org/article/803002049cce4586be99c647b801e593
Publikováno v:
Health Science Reports, Vol 7, Iss 3, Pp n/a-n/a (2024)
Abstract Background and Aims The United States of America and Sweden both contain a public and private component to their healthcare systems. While both countries spend a similar amount per capita on public healthcare expenditures, the United States
Externí odkaz:
https://doaj.org/article/0f017582ca0149138dc1687dd4d9c537
Autor:
Bhawna Sharma, Elena Bekerman, Hoa Truong, Johnny Lee, Maria Gamez-Guerrero, Archana Boopathy, Rohit Mital, Katell Bidet Huang, Sarah Ahmadi-Erber, Raphaela Wimmer, Sophie Schulha, Henning Lauterbach, Klaus Orlinger, Silpa Suthram, Mark G. Lewis, Wade Blair, Tariro Makadzange, Romas Geleziunas, Jeffrey P. Murry, Sarah Schmidt
Publikováno v:
Vaccines, Vol 12, Iss 7, p 735 (2024)
Arenavirus-based vectors are being investigated as therapeutic vaccine candidates with the potential to elicit robust CD8 T-cell responses. We compared the immunogenicity of replicating (artPICV and artLCMV) and non-replicating (rPICV and rLCMV) aren
Externí odkaz:
https://doaj.org/article/12cd484f588c476caa2e1468f51b5006