Zobrazeno 1 - 10
of 20
pro vyhledávání: '"P G, Dinning"'
Autor:
Bao Nan Chen, Adam G. Humenick, Timothy James Hibberd, Wai Ping Yew, David A. Wattchow, Phil G. Dinning, Marcello Costa, Nick J. Spencer, Simon J. H. Brookes
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2024)
Background and AimsViscerofugal neurons (VFNs) have cell bodies in the myenteric plexus and axons that project to sympathetic prevertebral ganglia. In animals they activate sympathetic motility reflexes and may modulate glucose metabolism and feeding
Externí odkaz:
https://doaj.org/article/0e7bc69334a1490bab30d7d4799ba1c4
Autor:
David Gunn, Rabia Topan, Ron Fried, Ivana Holloway, Richard Brindle, Suzanne Hartley, Lorna Barnard, Maura Corsetti, S Mark Scott, Adam Farmer, Ayesha Akbar, Maria Eugenicos, Nigel Trudgill, Kapil Kapur, John McLaughlin, David S Sanders, Arvind Ramadas, Peter Whorwell, Lesley Houghton, Phil G Dinning, Qasim Aziz, Alexander C Ford, Amanda Farrin, Robin Spiller
Publikováno v:
Efficacy and Mechanism Evaluation, Vol 10, Iss 09 (2023)
Background Irritable bowel syndrome with diarrhoea is characterised by frequent, loose or watery stools with associated urgency, resulting in marked reduction of quality of life. Ondansetron, a 5-hydroxytryptamine-3 receptor antagonist, has been show
Externí odkaz:
https://doaj.org/article/8e3c4c5bb58043b1b6ee827497831e62
Autor:
Bao Nan Chen, Adam Humenick, Wai Ping Yew, Rochelle A. Peterson, Lukasz Wiklendt, Phil G. Dinning, Nick J. Spencer, David A. Wattchow, Marcello Costa, Simon J.H. Brookes
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 16, Iss 4, Pp 573-605 (2023)
Background and Aims: Gut functions including motility, secretion, and blood flow are largely controlled by the enteric nervous system. Characterizing the different classes of enteric neurons in the human gut is an important step to understand how its
Externí odkaz:
https://doaj.org/article/3f46d0f11e5646c6821584fe647c2d87
Autor:
Timothy J. Hibberd, Stewart Ramsay, Phaedra Spencer-Merris, Phil G. Dinning, Vladimir P. Zagorodnyuk, Nick J. Spencer
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
A rhythmic expression of clock genes occurs within the cells of multiple organs and tissues throughout the body, termed “peripheral clocks.” Peripheral clocks are subject to entrainment by a multitude of factors, many of which are directly or ind
Externí odkaz:
https://doaj.org/article/5a05bf5e54064f1daff22bf9ce02d50a
Autor:
David J. Smolilo, Timothy J. Hibberd, Marcello Costa, Phil G. Dinning, Lauren J. Keightley, Dayan De Fontgalland, David A. Wattchow, Nick J. Spencer
Publikováno v:
Physiological Reports, Vol 11, Iss 1, Pp n/a-n/a (2023)
Abstract The speed of pellet propulsion through the isolated guinea pig distal colon in vitro significantly exceeds in vivo measurements, suggesting a role for inhibitory mechanisms from sources outside the gut. The aim of this study was to investiga
Externí odkaz:
https://doaj.org/article/7fa41f86df4b480d9207a16285caa0a9
Autor:
Michaela E. Johnson, Adam Humenick, Rochelle A. Peterson, Marcello Costa, David A. Wattchow, Tiong Cheng Sia, Phil G. Dinning, Simon J. H. Brookes
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
BackgroundIn the human large bowel, sacral parasympathetic nerves arise from S2 to S4, project to the pelvic plexus (“hypogastric plexus”) and have post-ganglionic axons entering the large bowel near the rectosigmoid junction. They then run long
Externí odkaz:
https://doaj.org/article/56d9c261bdf348d2aa73bb3f44148801
Autor:
Dominic R. Parker, Lukasz Wiklendt, Adam Humenick, Bao Nan Chen, Tiong Cheng Sia, David A. Wattchow, Phil G. Dinning, Simon J. H. Brookes
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
BackgroundThe sympathetic nervous system inhibits human colonic motility largely by effects on enteric neurons. Noradrenergic axons, which branch extensively in the myenteric plexus, are integral to this modulatory role, but whether they contact spec
Externí odkaz:
https://doaj.org/article/f5f8f6fb9b654217af2433629e3da1c4
Publikováno v:
Investigative and Clinical Urology, Vol 61, Iss 5, Pp 528-537 (2020)
Purpose: To confirm feasibility of recording pressure along the length of the urethra using a multi-sensor fibre-optic pressure catheter; to identify the spatial and temporal features of changes in pressure along the urethra at sites related to speci
Externí odkaz:
https://doaj.org/article/9feaca545a1640f1967b6184e3cf88ff
Autor:
Cameron I. Wells, Sameer Bhat, Nira Paskaranandavadivel, Anthony Y. Lin, Ryash Vather, Chris Varghese, James A. Penfold, David Rowbotham, Phil G. Dinning, Ian P. Bissett, Greg O’Grady
Publikováno v:
Physiological Reports, Vol 9, Iss 22, Pp n/a-n/a (2021)
Abstract Background Cyclic motor patterns (CMPs) are the most common motor pattern in the distal colon. This study used high‐resolution (HR) colonic manometry to quantify trends in distal colonic motor activity before elective colonic surgery, dete
Externí odkaz:
https://doaj.org/article/42581fc5bfdd49f795f3d4731eb267ca
Autor:
David Gunn, Ron Fried, Rabia Lalani, Amanda Farrin, Ivana Holloway, Tom Morris, Catherine Olivier, Rachael Kearns, Maura Corsetti, Mark Scott, Adam Farmer, Anton Emmanuel, Peter Whorwell, Yan Yiannakou, David Sanders, John Mclaughlin, Kapil Kapur, Maria Eugenicos, Ayesha Akbar, Nigel Trudgill, Lesley Houghton, Phil G. Dinning, Alexander C. Ford, Qasim Aziz, Robin Spiller
Publikováno v:
Trials, Vol 20, Iss 1, Pp 1-12 (2019)
Abstract Background Irritable bowel syndrome with diarrhoea (IBS-D) affects up to 4% of the general population. Symptoms include frequent, loose, or watery stools with associated urgency, resulting in marked reduction of quality of life and loss of w
Externí odkaz:
https://doaj.org/article/666fe80d7c1f434ab737aefe79301cbd