Zobrazeno 1 - 10
of 71
pro vyhledávání: '"P G, Dayton"'
Publikováno v:
Annals of the New York Academy of Sciences. 86:253-262
Autor:
P. G. Dayton, Zafar H Israili
Publikováno v:
Drug metabolism reviews. 33(2)
For about half a century, the binding of drugs to plasma albumin, the "silent receptor," has been recognized as one of the major determinants of drug action, distribution, and disposition. In the last decade, the binding of drugs, especially but not
Publikováno v:
Life Sciences. 14:837-852
An antibody against probenecid was obtained in rabbits immunized with probenecid conjugated to bovine serum albumin. The antibody exhibited a high degree of specificity (competitive assay) as shown by studies with 25 analogs which included isomers, h
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 232:305-314
A sensitive gas chromatographic method for quantitative analysis of ketamine and norketamine in human and animal biological fluids is described. The nitrogen-sensitive detection procedure used is more stable than electron-capture detection and reduce
Publikováno v:
Clinical Pharmacology & Therapeutics. 21:610-619
Triamterene is a pteridine used therapeutically as a diuretic. In order to better understand variations in effect and toxicity of triamterence in individuals, the fate of the drug in man was investigated. Both nonradioactive and 14C-labeled forms of
Publikováno v:
Clinical Chemistry. 23:745-748
We modified the micro-scale spectrophotofluorometric method of Miceli et al. [Biochem. Med. 12, 348 (1975)] for the assay of "apparent" isoniazid (isoniazid plus acid-labile hydrazones) to improve its clinical application. We also adapted the method
Publikováno v:
European Journal of Clinical Pharmacology. 24:825-831
We report for the first time that ketamine (K) is bound as much as 47% to human plasma. It was shown that binding of K to plasma and albumin is dependent on pH; binding is decreased at pH lower than 7.4 and increased at higher pH. This is in concorda
Publikováno v:
The American Journal of Tropical Medicine and Hygiene. 21:322-331
Publikováno v:
Experimental Biology and Medicine. 135:840-843
SummaryDialytic removal of alpha-methyldopa (Aldomet) has been investigated in chronic uremic patients undergoing either hemodialysis or peritoneal dialysis, using 14C tracer techniques. A mean of 60% of the estimated absorbed radioactivity was recov
Publikováno v:
Experimental Biology and Medicine. 129:438-443
SummaryThe action of methandrostenolone on phenylbutazone and its major metabolite, oxyphenbutazone, has been studied in man by determining the half-life and plateau plasma levels of the antirheumatic drugs. The anabolic steroid caused an increase in