Zobrazeno 1 - 10
of 86
pro vyhledávání: '"P F Zipfel"'
Autor:
Karin Heidenreich, Deepti Goel, P. S. Priyamvada, Sagar Kulkarni, Vipul Chakurkar, Dinesh Khullar, Ravi Singh, Charan Bale, Peter F. Zipfel
Publikováno v:
Frontiers in Nephrology, Vol 4 (2024)
C3 glomerulopathy (C3G) is an ultra-rare complement-mediated kidney disease caused by to the deregulation of the alternative pathway (AP) of proximal complement. Consequently, all effector loops of the complement are active and can lead to pathologie
Externí odkaz:
https://doaj.org/article/b8df9dbc8a8e4fb69f815ce532d9d682
Autor:
Todor Tschongov, Swagata Konwar, Andreas Busch, Christian Sievert, Andrea Hartmann, Marina Noris, Sara Gastoldi, Sistiana Aiello, Andreas Schaaf, Jens Panse, Peter F. Zipfel, Paulina Dabrowska-Schlepp, Karsten Häffner
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Most drugs that target the complement system are designed to inhibit the complement pathway at either the proximal or terminal levels. The use of a natural complement regulator such as factor H (FH) could provide a superior treatment option by restor
Externí odkaz:
https://doaj.org/article/316e4e983cf84c93b83284c77b9c1ed8
Autor:
Iman Rabeeah, Elizabeth Billington, Béatrice Nal, Jean-Remy Sadeyen, Ansar A. Pathan, Munir Iqbal, Nigel J. Temperton, Peter F. Zipfel, Christine Skerka, Uday Kishore, Holly Shelton
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The complement system is an innate immune mechanism against microbial infections. It involves a cascade of effector molecules that is activated via classical, lectin and alternative pathways. Consequently, many pathogens bind to or incorporate in the
Externí odkaz:
https://doaj.org/article/8881a6fce7e34af3bf188ad7f814d058
Autor:
Larissa Seifert, Gunther Zahner, Catherine Meyer-Schwesinger, Naemi Hickstein, Silke Dehde, Sonia Wulf, Sarah M. S. Köllner, Renke Lucas, Dominik Kylies, Sarah Froembling, Stephanie Zielinski, Oliver Kretz, Anna Borodovsky, Sergey Biniaminov, Yanyan Wang, Hong Cheng, Friedrich Koch-Nolte, Peter F. Zipfel, Helmut Hopfer, Victor G. Puelles, Ulf Panzer, Tobias B. Huber, Thorsten Wiech, Nicola M. Tomas
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
It is generally thought that complement activation in human membranous nephropathy (MN) occurs predominantly via the lectin or alternative pathway. Here, the authors show that the classical pathway is the dominant form of complement activation in MN
Externí odkaz:
https://doaj.org/article/c71d3e45f83243fc953b6a19b9d58113
Autor:
Miriana Battista, Bianca Hoffmann, Yann Bachelot, Lioba Zimmermann, Laura Teuber, Aurélie Jost, Susanne Linde, Martin Westermann, Mario M. Müller, Hortense Slevogt, Sven Hammerschmidt, Marc Thilo Figge, Cláudia Vilhena, Peter F. Zipfel
Publikováno v:
mSphere, Vol 8, Iss 4 (2023)
ABSTRACT Streptococcus pneumoniae-induced hemolytic uremic syndrome (Sp-HUS) is a kidney disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury. This disease is frequently underdiagnosed and its pathophy
Externí odkaz:
https://doaj.org/article/287729874db041a79fe9e2085861f5e7
Autor:
Thi-Huong Nguyen, Li-Yu Chen, Nida Zaman Khan, Annerose Lindenbauer, Van-Chien Bui, Peter F. Zipfel, Doris Heinrich
Publikováno v:
Biomolecules, Vol 14, Iss 3, p 245 (2024)
Pathogenic platelet factor 4 (PF4) antibodies contributed to the abnormal coagulation profiles in COVID-19 and vaccinated patients. However, the mechanism of what triggers the body to produce these antibodies has not yet been clarified. Similar patte
Externí odkaz:
https://doaj.org/article/873f051a8c3447da842f270f84ddf12e
Autor:
Catharina Busch, Saskia Rau, Andjela Sekulic, Luce Perie, Christian Huber, Miranda Gehrke, Antonia M. Joussen, Peter F. Zipfel, Gerhild Wildner, Christine Skerka, Olaf Strauß
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
PurposePolymorphisms in complement genes are risk-associated for age-related macular degeneration (AMD). Functional analysis revealed a common deficiency to control the alternative complement pathway by risk-associated gene polymorphisms. Thus, we in
Externí odkaz:
https://doaj.org/article/4a86c97d171b4bc89484371f79ff0d29
Autor:
Anahita Shahraz, Yuchen Lin, Joshua Mbroh, Jonas Winkler, Huan Liao, Marie Lackmann, Annemarie Bungartz, Peter F. Zipfel, Christine Skerka, Harald Neumann
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Sialic acids as the terminal caps of the cellular glycocalyx play an essential role in self-recognition and were shown to modulate complement processes via interaction between α2,3-linked sialic acids and complement factor H. Previously, it
Externí odkaz:
https://doaj.org/article/5e18edd0668c4872b5d67eae4e59fb39
Autor:
Natalia Ruiz-Molina, Juliana Parsons, Madeleine Müller, Sebastian N. W. Hoernstein, Lennard L. Bohlender, Steffen Pumple, Peter F. Zipfel, Karsten Häffner, Ralf Reski, Eva L. Decker
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
Ruiz-Molina et al. design a synthetic protein, MFHR13, as a multi-target complement regulator. They demonstrate that it protects sheep erythrocytes from complement attack exhibiting 26 and 4-fold the regulatory activity of eculizumab and human Factor
Externí odkaz:
https://doaj.org/article/0d939a14797d46a4b48d77263b3814c8
Autor:
Sarah Irmscher, Svante L. H. Zipfel, Luke D. Halder, Lia Ivanov, Andres Gonzalez-Delgado, Christoph Waldeyer, Moritz Seiffert, Fabian J. Brunner, Monika von der Heide, Ina Löschmann, Sonia Wulf, Darina Czamara, Nikolina Papac-Milicevic, Olaf Strauß, Stefan Lorkowski, Hermann Reichenspurner, Michael V. Holers, Nirmal K. Banda, Tania Zeller, Elisabeth B. Binder, Christoph J. Binder, Thorsten Wiech, Peter F. Zipfel, Christine Skerka
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Atherosclerotic cardiovascular disease (ACVD) is a lipid-driven inflammatory disease and one of the leading causes of death worldwide. Lipid deposits in the arterial wall lead to the formation of plaques that involve lipid oxidation, cellula
Externí odkaz:
https://doaj.org/article/f4fef222f3624b56b6f873bb7fc7bb7a