Zobrazeno 1 - 10
of 21
pro vyhledávání: '"P F Life"'
Autor:
P. J. T. Koshy, K. Hudson, Andrew D. Rowan, W. D. Shingleton, B. A. Degnan, P. F. Life, A. B. Vernallis, J. R. Spaull, Tim E. Cawston, John K. Heath
Publikováno v:
Arthritis & Rheumatism. 44:1620-1632
Objective To determine whether other glycoprotein 130 (gp130) binding cytokines can mimic the effects of oncostatin M (OSM) in acting synergistically with interleukin-1α (IL-1α) to induce cartilage collagen breakdown and collagenase expression, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd4df44f84b382285dcfd183c0c37b28
https://doi.org/10.1002/1529-0131(200107)44:7<1620::aid-art285>3.0.co
https://doi.org/10.1002/1529-0131(200107)44:7<1620::aid-art285>3.0.co
Autor:
Mike Salmon, Janet M. Lord, Dagmar Scheel-Toellner, Leonie S. Taams, Arne N. Akbar, Tina Sanyal, P. F. Life, Darrell Pilling, Giovanna Lombardi, Pádraic J. Dunne
Publikováno v:
Europe PubMed Central
Anergic T cells have immunoregulatory activity and can survive for extended periods in vivo. It is unclear how anergic T cells escape from deletion, because both anergy and apoptosis can occur after TCR ligation. Stimulation of human CD4+ T cell clon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e1b68cc64aca589eefd67e52d64f9d7
https://doi.org/10.4049/jimmunol.165.7.3782
https://doi.org/10.4049/jimmunol.165.7.3782
Autor:
A Dalgleish, K Singh, A M Deakin, R J Leicester, J H Ellis, C J Finlayson, W F A Miles, P F Life, J S Crowe
Publikováno v:
Clinical and Experimental Immunology. 118:197-204
SUMMARYLoss of the T cell receptor-associated CD3 ζ chain has been proposed as a possible mechanism of the acquired immunosuppression in both tumour-bearing hosts, and in symptomatic patients with HIV infection. However, other reports suggest that t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c9873949f1aa772a4a2e278255aa2a6
https://doi.org/10.1046/j.1365-2249.1999.01044.x
https://doi.org/10.1046/j.1365-2249.1999.01044.x
Autor:
P. J. T. Koshy, Graham P. Riley, J. R. Spaull, P. F. Life, C. A. Summers, V. A. Curry, Tim E. Cawston, Andrew D. Rowan, Ian M. Clark, Mary B. Goldring, W. D. Shingleton
Publikováno v:
Arthritis & Rheumatism. 41:1760-1771
Objective. To study the interaction of interleukin-la (IL-la) and oncostatin M (OSM) in promoting cartilage collagen destruction. Methods. Bovine, porcine, and human cartilage and human chondrocytes were studied in culture. The levels of collagenase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b85383a20d183fe72a7d046b3e7ce918
https://doi.org/10.1002/1529-0131(199810)41:10<1760::aid-art8>3.0.co
https://doi.org/10.1002/1529-0131(199810)41:10<1760::aid-art8>3.0.co
Autor:
K B Bacon, L Flores-Romo, P F Life, D D Taub, B A Premack, S J Arkinstall, T N Wells, T J Schall, C A Power
Publikováno v:
The Journal of Immunology. 154:3654-3666
We have characterized the IL-8-induced signal transduction processes in T lymphocytes. A basal level of IL-8 receptor expression was shown on mixed PBL, as identified by using phycoerythrin (PE)-coupled IL-8, and this expression was increased followi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::732bd9b2635fdfa055d61fea16eae409
https://doi.org/10.4049/jimmunol.154.8.3654
https://doi.org/10.4049/jimmunol.154.8.3654
Publikováno v:
Arthritis & Rheumatism. 34:1151-1157
Synovial fluid (SF) mononuclear cells from patients with reactive arthritis (ReA) proliferate in vitro when challenged with ReA-associated bacteria, the maximal response being for the organism causing the triggering infection. We report the results o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccb90c6f678441598327cdabcec668b8
https://doi.org/10.1002/art.1780340911
https://doi.org/10.1002/art.1780340911
Publikováno v:
Annals of the rheumatic diseases. 61(8)
Objective: To investigate whether interleukin 17 (IL17), derived specifically from T cells, can promote type II collagen release from cartilage. The ability of IL17 to synergise with other proinflammatory mediators to induce collagen release from car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a688c4af87889591288e5e8756934025
https://pubmed.ncbi.nlm.nih.gov/12117676
https://pubmed.ncbi.nlm.nih.gov/12117676
Publikováno v:
Arthritis and rheumatism. 44(11)
Oncostatin M (OSM) is a member of the interleukin-6 cytokine family, with well-documented effects on cell growth and differentiation. OSM also has proinflammatory and cartilage degradative properties. The aim of this study was to investigate the sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::55a6342a238df67dc80ace63ae34f968
https://pubmed.ncbi.nlm.nih.gov/11710726
https://pubmed.ncbi.nlm.nih.gov/11710726
Autor:
A D, Rowan, P J, Koshy, W D, Shingleton, B A, Degnan, J K, Heath, A B, Vernallis, J R, Spaull, P F, Life, K, Hudson, T E, Cawston
Publikováno v:
Arthritis and rheumatism. 44(7)
To determine whether other glycoprotein 130 (gp130) binding cytokines can mimic the effects of oncostatin M (OSM) in acting synergistically with interleukin-1alpha (IL-1alpha) to induce cartilage collagen breakdown and collagenase expression, and to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c5eecae77f2c1c2de274098e25f8612d
https://pubmed.ncbi.nlm.nih.gov/11465713
https://pubmed.ncbi.nlm.nih.gov/11465713
Autor:
T E, Cawston, V A, Curry, C A, Summers, I M, Clark, G P, Riley, P F, Life, J R, Spaull, M B, Goldring, P J, Koshy, A D, Rowan, W D, Shingleton
Publikováno v:
Arthritis and rheumatism. 41(10)
To study the interaction of interleukin-1alpha (IL-1alpha) and oncostatin M (OSM) in promoting cartilage collagen destruction.Bovine, porcine, and human cartilage and human chondrocytes were studied in culture. The levels of collagenase (matrix metal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::98b6623a6ee0244b4f3854cc3d70b60e
https://pubmed.ncbi.nlm.nih.gov/9778217
https://pubmed.ncbi.nlm.nih.gov/9778217