Zobrazeno 1 - 10 of 26 pro vyhledávání: '"P F Agris"'
1
Akademický článek
Modification of messenger RNA by 2′-O-methylation regulates gene expression in vivo
Autor: Brittany A. Elliott, Hsiang-Ting Ho, Srivathsan V. Ranganathan, Sweta Vangaveti, Olga Ilkayeva, Hala Abou Assi, Alex K. Choi, Paul F. Agris, Christopher L. Holley
Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
The post-transcriptional modification of mRNAs provides an additional layer to gene expression regulation. Here the authors show that 2′-O-methylation mediated by box C/D snoRNAs and fibrillarin can inhibit the translation of target mRNAs.
Externí odkaz: https://doaj.org/article/b5583f16311b4eff9351aede56bc09e1
Zobrazit plný text záznamu
2
Akademický článek
Silencing of the tRNA Modification Enzyme Cdkal1 Effects Functional Insulin Synthesis in NIT-1 Cells: tRNALys3 Lacking ms2- (ms2t6A37) is Unable to Establish Sufficient Anticodon:Codon Interactions to Decode the Wobble Codon AAG
Autor: Amithi Narendran, Sweta Vangaveti, Srivathsan V. Ranganathan, Emily Eruysal, Miranda Craft, Omar Alrifai, Fu Yee Chua, Kathryn Sarachan, Breann Litwa, Sheetal Ramachandran, Paul F. Agris
Publikováno v: Frontiers in Molecular Biosciences, Vol 7 (2021)
Human Genome Wide Association Studies found a significant risk of Type 2 Diabetes Mellitus (T2DM) in single nucleotide polymorphisms in the cdkal1 gene. The cdkal1 gene is remote from the insulin gene and with the surprising function of a specific tR
Externí odkaz: https://doaj.org/article/7e2efb8a6d744d18a4c00bda6520c179
Zobrazit plný text záznamu
3
Akademický článek
A New Promising Anti-Infective Agent Inhibits Biofilm Growth by Targeting Simultaneously a Conserved RNA Function That Controls Multiple Genes
Autor: Thorsten M. Seyler, Christina Moore, Haein Kim, Sheetal Ramachandran, Paul F. Agris
Publikováno v: Antibiotics, Vol 10, Iss 1, p 41 (2021)
Combating single and multi-drug-resistant infections in the form of biofilms is an immediate challenge. The challenge is to discover innovative targets and develop novel chemistries that combat biofilms and drug-resistant organisms, and thwart emerge
Externí odkaz: https://doaj.org/article/a9de368f256249be95202385f112ce7c
Zobrazit plný text záznamu
4
Akademický článek
Chemical and Conformational Diversity of Modified Nucleosides Affects tRNA Structure and Function
Autor: Ville Y. P. Väre, Emily R. Eruysal, Amithi Narendran, Kathryn L. Sarachan, Paul F. Agris
Publikováno v: Biomolecules, Vol 7, Iss 1, p 29 (2017)
RNAs are central to all gene expression through the control of protein synthesis. Four major nucleosides, adenosine, guanosine, cytidine and uridine, compose RNAs and provide sequence variation, but are limited in contributions to structural variatio
Externí odkaz: https://doaj.org/article/b4e07cdc49054ee98b37189aa434f8f2
Zobrazit plný text záznamu
5
Role of modified nucleosides of yeast tRNA(Phe) in ribosomal binding
Autor: S S, Ashraf, R H, Guenther, G, Ansari, A, Malkiewicz, E, Sochacka, P F, Agris
Publikováno v: Cell biochemistry and biophysics. 33(3)
Naturally occurring nucleoside modifications are an intrinsic feature of transfer RNA (tRNA), and have been implicated in the efficiency, as well as accuracy-of codon recognition. The structural and functional contributions of the modified nucleoside
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e0c854a6a42868c98fa5c683efe2bb29
https://pubmed.ncbi.nlm.nih.gov/11325044
Zobrazit plný text záznamu
6
Unconventional structure of tRNA(Lys)SUU anticodon explains tRNA's role in bacterial and mammalian ribosomal frameshifting and primer selection by HIV-1
Autor: P F, Agris, R, Guenther, P C, Ingram, M M, Basti, J W, Stuart, E, Sochacka, A, Malkiewicz
Publikováno v: RNA (New York, N.Y.). 3(4)
Transfer RNA(Lys)SUU, with a 5-modified-2-thiouridine at wobble position 34, facilitates -1 frameshifts for correct translation of the Escherichia coli DNA polymerase gamma subunit and retroviral polymerases. Peptidyl-tRNA(Lys)SUU prematurely termina
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2048cca751f80dfbf89742a5aa744c1c
https://pubmed.ncbi.nlm.nih.gov/9085848
Zobrazit plný text záznamu
7
Ribosomal binding of modified tRNA anticodons related to thermal stability
Autor: S S, Ashraf, R, Guenther, W, Ye, Y, Lee, A, Malkiewicz, P F, Agris
Publikováno v: Nucleic acids symposium series. (36)
The physicochemical contributions of modified nucleosides to tRNA functions are not well understood. In order to determine the contributions of specific modifications to tRNA stability as well as to ribosomal binding, ten variously modified yeast tRN
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::14d3739e9fa733bae3ed421b6adfa460
https://pubmed.ncbi.nlm.nih.gov/9478206
Zobrazit plný text záznamu
10
Importance of modified nucleosides to the structure and function of tRNAs
Autor: P F, Agris, A, Malkiewicz, R, Guenther, M, Basti, R, Sengupta, J, Stuart
Publikováno v: Nucleic acids symposium series. (33)
Although a few modifications are found in DNA, 93 modified nucleosides have been found in the various RNAs. For the most part, the chemistry and structure that modified nucleosides, individually and in combination, uniquely contribute to DNA or RNA f
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8ecfe734435a9b9e278051d3e1e2f45f
https://pubmed.ncbi.nlm.nih.gov/8643387
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje