Zobrazeno 1 - 10
of 33
pro vyhledávání: '"P F, Vonvoigtlander"'
Publikováno v:
Neuroscience. 73:705-713
Thyroid hormones, which are known to act by genomic mechanisms in peripheral tissues, were found to influence the binding and function of the GABAA receptor complex in brain membranes. Submicromolar concentrations of triiodothyronine and thyroxine st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fed1649af4a2ed618d876dbd8af4c6e8
https://doi.org/10.1016/0306-4522(96)00052-8
https://doi.org/10.1016/0306-4522(96)00052-8
Publikováno v:
British journal of pharmacology. 123(8)
1. Imidazoquinoxaline PNU-97775 and imidazoquinoline PNU-101017 are benzodiazepine site ligands with a second low affinity binding site on GABA(A) receptors, the occupancy of which at high drug concentrations reverses their positive allosteric activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6c164e8de25a2b759bc145bb998f5bc5
https://pubmed.ncbi.nlm.nih.gov/9605552
https://pubmed.ncbi.nlm.nih.gov/9605552
Publikováno v:
British journal of pharmacology. 122(5)
1. We discovered a novel gamma-aminobutyric acidA (GABA(A)) receptor ligand displaying seemingly opposite functionalities, depending on the alpha isoform of the alpha(x)beta2gamma2 subtypes. PNU-107484A enhanced GABA-induced Cl- currents in the alpha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::796ba04d5c2afefeede516ea6be2b533
https://pubmed.ncbi.nlm.nih.gov/9384496
https://pubmed.ncbi.nlm.nih.gov/9384496
Autor:
E D, Hall, P K, Andrus, S L, Smith, T J, Fleck, H M, Scherch, B S, Lutzke, G A, Sawada, J S, Althaus, P F, Vonvoigtlander, G E, Padbury, P G, Larson, J R, Palmer, G L, Bundy
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 281(2)
A novel group of antioxidant compounds, the pyrrolopyrimidines, has been discovered recently. Many of these possess significantly improved oral bioavailability (56-70% in rats), increased efficacy and potency in protecting cultured neurons against ir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cda9d59b6e3e37f452e3b016753fb48c
https://pubmed.ncbi.nlm.nih.gov/9152399
https://pubmed.ncbi.nlm.nih.gov/9152399
Autor:
K M, Merchant, G S, Gill, D W, Harris, R M, Huff, M J, Eaton, K, Lookingland, B S, Lutzke, R B, Mccall, M F, Piercey, P J, Schreur, V H, Sethy, M W, Smith, K A, Svensson, A H, Tang, P F, Vonvoigtlander, R E, Tenbrink
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 279(3)
Dopamine D2-like receptors play an important role in the pharmacotherapy of psychotic disorders. Molecular and cellular techniques have identified distinct gene products (D2-long, D2-short, D3 and D4) displaying the D2 receptor pharmacology. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::259d6fa65fe3dc2859628be188e3cc22
https://pubmed.ncbi.nlm.nih.gov/8968364
https://pubmed.ncbi.nlm.nih.gov/8968364
U-90042, a sedative/hypnotic compound that interacts differentially with the GABAA receptor subtypes
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 275(2)
U-90042 is a structurally novel compound that has comparable affinities for binding to three recombinant subtypes of the gamma-aminobutyric acidA receptor: alpha 1 beta 2 gamma 2, alpha 3 beta 2 gamma 2 and alpha 6 beta 2 gamma 2. The relatively high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a43e8f2afa6b04865817d47d03a86016
https://pubmed.ncbi.nlm.nih.gov/7473164
https://pubmed.ncbi.nlm.nih.gov/7473164
Publikováno v:
Research communications in molecular pathology and pharmacology. 87(3)
Peroxynitrite may be a physiologically relevant endogenous neurotoxin that forms following CNS trauma when excessive levels of NO and .O2 accumulate. Recently, peroxynitrite was found to inactivate the polyclonal antibody to cAMP. A feasibility study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::444b87467c82f8d677b51f55d4e609b2
https://pubmed.ncbi.nlm.nih.gov/7620829
https://pubmed.ncbi.nlm.nih.gov/7620829
Autor:
M F, Piercey, A H, Tang, R A, Lahti, P F, VonVoigtlander, P J, Schreur, R B, McCall, J T, Lum-Ragan, W E, Hoffmann, S R, Franklin, R A, Code
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 268(3)
U-67413B (4-hydroxydipropylaminodihydrophenalene) bound with high affinity to both 5-hydroxytryptamine (HT)1A and D2-dopamine (DA) receptor sites. U-67413B depressed 5-HT and DA cell firing rates and depressed synthesis of both neurotransmitters. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4f2db64e33d1b463083a75390ed65e81
https://pubmed.ncbi.nlm.nih.gov/7908053
https://pubmed.ncbi.nlm.nih.gov/7908053
Publikováno v:
Research communications in chemical pathology and pharmacology. 83(3)
Nitric oxide (NO) is made by NO synthase during the conversion of arginine to citrulline. Researchers have found that they can block the actions of excitotoxins by inhibiting NO synthase. Released from excitable cells during trauma, NO may react with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eb213376554f07e1aaec182c445e65fe
https://pubmed.ncbi.nlm.nih.gov/8008974
https://pubmed.ncbi.nlm.nih.gov/8008974
Publikováno v:
Molecular pharmacology. 44(4)
Previous studies with cloned gamma-aminobutyric acid type A receptors expressed in human embryonic kidney cells have indicated that the alpha 1 beta 2 gamma 2 and alpha 1 gamma 2 (but not alpha 1 beta 2) subtypes have benzodiazepine sites. We found i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::86511fbfc700e257c5a9d94ece221789
https://pubmed.ncbi.nlm.nih.gov/7901754
https://pubmed.ncbi.nlm.nih.gov/7901754