Zobrazeno 1 - 10
of 189
pro vyhledávání: '"P F, Mannaioni"'
Publikováno v:
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry. 5:335-352
Non-steroidal anti-inflammatory drugs (NSAIDs) are a structurally diverse group of similarly acting compounds that are widely prescribed and used for the management of pain associated with inflammatory conditions. Our present aim is to choose a leadi
Publikováno v:
Inflammation Research. 55:261-273
The double origin of carbon monoxide (CO) as an atmospheric pollutant or as an endogenous gaseous modulator of many pathophysiological processes prompted us to review some aspects of the bad side and of the good side of coin among the pleiotropic eff
Autor:
Simone Pierpaoli, Lucia Giannini, Alfredo Vannacci, Roberto Mazzanti, Cosimo Marzocca, Ornella Fantappiè, P. F. Mannaioni, Emanuela Masini
Publikováno v:
Università degli studi di Firenze-IRIS
Scopus-Elsevier
Scopus-Elsevier
Carbon monoxide (CO) is a signaling gas produced intracellularly by heme oxygenase (HO) enzymes using heme as a substrate. During heme breakdown, HO-1 and HO-2 release CO, biliverdin, and Fe2+. In this study, we investigated the effects of manipulati
Autor:
Giovanni Zagli, P. F. Mannaioni, Daniele Bani, J. F. Ndisang, Michela Solazzo, Emanuela Masini
Publikováno v:
British Journal of Pharmacology. 137:337-344
Relaxin (RLX) is a multifunctional hormone best known for its role in pregnancy and parturition, that has been also shown to influence coronary perfusion and mast cell activation through the generation of endogenous nitric oxide (NO). In this study w
Publikováno v:
Inflammation Research. 51:259-264
Objective and design: To understand whether the pseudo-allergic reactions to amphotericin B (AmB) administration are due to AmB or to the solubilizing vehicles, a study was designed to evaluate the effects of AmB, liposomal AmB, (L-AmB), AmB-deoxycho
Autor:
Dorigo B, A.M. Zorn, W. Dorigo, P. F. Mannaioni, Anna Maria Cameli, Maurizio Trapani, M. Moncini
Publikováno v:
Scopus-Elsevier
The aim of this study is to compare the values of hematologic and hemorheo logic parameters in preclinic alcoholists, i.e. without or with limited liver da mage (moderate steatosis in 38% of the cases), in basal conditions and after alcohol withd
Publikováno v:
British Journal of Pharmacology. 115:629-635
1. Two polydeoxyribonucleotides, produced by the controlled hydrolysis of DNA of mammalian lung (defibrotide and its lower molecular weight fraction, P.O. 085 DV), were studied for their ability to modify the release of nitrite and the coronary flow
Publikováno v:
Agents and Actions. 36:C268-C271
Rat serosal mast cells (MCs) isolated from Wistar albino rats synthesize a nitric oxide (NO)-like factor which inhibits platelet aggregation, stimulates guanylate cyclase and modulates mast cell histamine release. Aging can affect the ability of MCs
Publikováno v:
Agents and Actions. 36:C402-C405
The influence of histamine on human platelet function was studied by measuring the uptake of [3H]-histamine and by evaluating the effect of histamine on Ca2+ influx and on intracellular Ca2+ levels. The uptake of histamine by platelets is significant
Publikováno v:
International Archives of Allergy and Immunology. 99:404-407
Isolated perfused hearts and serosal mast cells (MC) of 2- 6- and 18-month-old spontaneously hypertensive rats (SH) were compared to hearts and MC from Wistar-Kyoto (WKY) rats of the same age for their ability to release nitric oxide (NO). The relati