Zobrazeno 1 - 10
of 75
pro vyhledávání: '"P F, Hollenberg"'
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 296(1)
Naturally occurring isothiocyanates, such as benzyl isothiocyanate (BITC), are potent and selective inhibitors of carcinogenesis induced by a variety of chemical carcinogens. These effects appear to be mediated through favorable modification of both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7aa1e90531382da39c732f134d947ee8
https://pubmed.ncbi.nlm.nih.gov/11123381
https://pubmed.ncbi.nlm.nih.gov/11123381
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 28(8)
2-Phenyl-2-(1-piperidinyl)propane (PPP), an analog of phencyclidine, was tested for its ability to inactivate cytochrome P450s (P450s) 2B1 and 2B6. PPP inactivated the 7-(benzyloxy)resorufin O-dealkylation activity of liver microsomes obtained from p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::699890cba2589b5baaac5320b1f77edd
https://pubmed.ncbi.nlm.nih.gov/10901699
https://pubmed.ncbi.nlm.nih.gov/10901699
Autor:
S M, Strobel, G D, Szklarz, Y, He, M, Foroozesh, W L, Alworth, E S, Roberts, P F, Hollenberg, J R, Halpert
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 290(1)
Rabbit cytochromes P-450 (P-450) 2B4 and 2B5 differ by only 12 amino acid residues yet they exhibit unique steroid hydroxylation profiles. Previous studies have led to the identification of active site residues that are determinants of these specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3586e3ded6ab86b4f0f6802242c8d7a6
https://pubmed.ncbi.nlm.nih.gov/10381811
https://pubmed.ncbi.nlm.nih.gov/10381811
Autor:
A P, Armstrong, P F, Hollenberg
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 27(6)
Mechanism-based inactivators serve as probes of enzyme mechanism, function, and structure. Koshland's Reagent II (2-methoxy-5-nitrobenzyl bromide, KR-II) is a potential mechanism-based inactivator of enzymes that perform O-dealkylations. The major ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::acecf85e23f9fcf811ab27448cfd69b8
https://pubmed.ncbi.nlm.nih.gov/10348806
https://pubmed.ncbi.nlm.nih.gov/10348806
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 27(5)
Fifteen xanthates with carbon chains of different lengths or substitutions, including the antiviral compound D609 (O-tricyclo[5.2. 1.0(2,6)]dec-9-yl-dithiocarbonate), were tested for their ability to inactivate cytochromes P-450 (P-450s) 2B1 and 2B6.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5583791547a449d40c99b14e601b3ee8
https://pubmed.ncbi.nlm.nih.gov/10220489
https://pubmed.ncbi.nlm.nih.gov/10220489
Publikováno v:
Chemical research in toxicology. 11(10)
Several naturally occurring and synthethic isothiocyanates were evaluated for their ability to inactivate the major ethanol-inducible hepatic cytochrome P450 2E1. Of the compounds tested, tert-butylisothiocyanate (tBITC) was found to be the most sele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5cfc024011c6bd440a091c3e8bf68b59
https://pubmed.ncbi.nlm.nih.gov/9778311
https://pubmed.ncbi.nlm.nih.gov/9778311
Autor:
P, Schmiedlin-Ren, D J, Edwards, M E, Fitzsimmons, K, He, K S, Lown, P M, Woster, A, Rahman, K E, Thummel, J M, Fisher, P F, Hollenberg, P B, Watkins
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 25(11)
Grapefruit juice increases the oral availability of a variety of CYP3A4 substrates. It has been shown that recurrent grapefruit juice ingestion results in a loss of CYP3A4 from the small bowel epithelium. We now show that the reduction in intestinal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bbfda32fea2885ffa0f73700904057d9
https://pubmed.ncbi.nlm.nih.gov/9351897
https://pubmed.ncbi.nlm.nih.gov/9351897
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 25(11)
The time-dependent loss of the 7-ethoxy-4-trifluoromethylcoumarin (EFC) O-deethylase activity of rat P450 2B1, rabbit P450 2B4, or dog P450 2B11 by 1-ethynylnaphthalene (1EN), 2-ethynylnaphthalene (2EN), 2-(1-propynyl)naphthalene (2PN), 1-ethynylanth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5d8d6eecf45b97df7e2568178c2dddc4
https://pubmed.ncbi.nlm.nih.gov/9351899
https://pubmed.ncbi.nlm.nih.gov/9351899
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 25(2)
Phencyclidine (PCP) inactivates the 7-ethoxy-4-trifluoromethylcoumarin O-deethylase activity of P4502B1 in a reconstituted system containing NADPH-cytochrome P450 (P450) reductase (reductase) and L-alpha-phosphatidylcholine, dilauroyl in a time-, con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e5228c86fd2c98fac71bcf92af44bb91
https://pubmed.ncbi.nlm.nih.gov/9029055
https://pubmed.ncbi.nlm.nih.gov/9029055
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 24(11)
The monoamine oxidase inhibitor clorgyline was found to inactivate purified reconstituted cytochrome P450 (P450) 2B1 in a time- and concentration-dependent manner (Sharma et al., Drug Metab. Dispos. 24, 669-675, 1996). In an attempt to explain the me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::62f21b354a1272f936f46e236bf4a79a
https://pubmed.ncbi.nlm.nih.gov/8937860
https://pubmed.ncbi.nlm.nih.gov/8937860