Zobrazeno 1 - 10
of 56
pro vyhledávání: '"P F, Cowman"'
Autor:
Madeline G. Dans, Coralie Boulet, Gabrielle M. Watson, William Nguyen, Jerzy M. Dziekan, Cindy Evelyn, Kitsanapong Reaksudsan, Somya Mehra, Zahra Razook, Niall D. Geoghegan, Michael J. Mlodzianoski, Christopher Dean Goodman, Dawson B. Ling, Thorey K. Jonsdottir, Joshua Tong, Mufuliat Toyin Famodimu, Mojca Kristan, Harry Pollard, Lindsay B. Stewart, Luke Brandner-Garrod, Colin J. Sutherland, Michael J. Delves, Geoffrey I. McFadden, Alyssa E. Barry, Brendan S. Crabb, Tania F. de Koning-Ward, Kelly L. Rogers, Alan F. Cowman, Wai-Hong Tham, Brad E. Sleebs, Paul R. Gilson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract With resistance to most antimalarials increasing, it is imperative that new drugs are developed. We previously identified an aryl acetamide compound, MMV006833 (M-833), that inhibited the ring-stage development of newly invaded merozoites. H
Externí odkaz:
https://doaj.org/article/ff89181888414cdebed058704ff392b1
Publikováno v:
Ecology and Evolution, Vol 14, Iss 8, Pp n/a-n/a (2024)
Abstract The targeted capture of ultraconserved elements (UCEs) has substantially increased the amount of genetic data available for phylogenomic reconstructions. These capture datasets frequently contain mitochondrial DNA as a by‐product, often in
Externí odkaz:
https://doaj.org/article/9e3ec36ddfe140c8ad851ceb9f3e3f44
Autor:
Iain R. Caldwell, Jean-Paul A. Hobbs, Brian W. Bowen, Peter F. Cowman, Joseph D. DiBattista, Jon L. Whitney, Pauliina A. Ahti, Roy Belderok, Sean Canfield, Richard R. Coleman, Matthew Iacchei, Erika C. Johnston, Ingrid Knapp, Eileen M. Nalley, Timo M. Staeudle, Áki Jarl Láruson
Publikováno v:
Cell Reports Sustainability, Vol 1, Iss 5, Pp 100082- (2024)
Summary: Efforts to conserve biodiversity have been hampered by long-standing biases, including a disproportionate focus on particular taxa and ecosystems with minimal attention to underlying genetic diversity. We assessed whether these biases have p
Externí odkaz:
https://doaj.org/article/2ea80dbce82f4b41b343fe3111989b3a
Autor:
Madeline G. Dans, Coralie Boulet, Gabrielle M. Watson, William Nguyen, Jerzy M. Dziekan, Cindy Evelyn, Kitsanapong Reaksudsan, Somya Mehra, Zahra Razook, Niall D. Geoghegan, Michael J. Mlodzianoski, Christopher Dean Goodman, Dawson B. Ling, Thorey K. Jonsdottir, Joshua Tong, Mufuliat Toyin Famodimu, Mojca Kristan, Harry Pollard, Lindsay B. Stewart, Luke Brandner-Garrod, Colin J. Sutherland, Michael J. Delves, Geoffrey I. McFadden, Alyssa E. Barry, Brendan S. Crabb, Tania F. de Koning-Ward, Kelly L. Rogers, Alan F. Cowman, Wai-Hong Tham, Brad E. Sleebs, Paul R. Gilson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/36bf3afec36e4aac961dcc7fb75d1e5e
Publikováno v:
Ecology and Evolution, Vol 14, Iss 3, Pp n/a-n/a (2024)
Abstract Understanding the numerous roles that colouration serves in the natural world has remained a central focus in many evolutionary and ecological studies. However, to accurately characterise and then compare colours or patterns among individual
Externí odkaz:
https://doaj.org/article/65ae619ab90a49619f8a51f2a0e72543
Autor:
Myo T. Naung, Elijah Martin, Wilson Wong, Zahra Razook, Digjaya Utama, Andrew J. Guy, Shannon Takala Harrison, Alan F. Cowman, Enmoore Lin, Benson Kiniboro, Moses Laman, Ivo Mueller, Alyssa E. Barry
Publikováno v:
Frontiers in Parasitology, Vol 2 (2023)
Plasmodium falciparum Reticulocyte Binding Protein Homologue (RH5), a leading malaria vaccine candidate, is essential for erythrocyte invasion by the parasite, interacting with the human host receptor, basigin. RH5 has a small number of polymorphisms
Externí odkaz:
https://doaj.org/article/9c0eded36cbd4ed89c86f1699d2705be
Autor:
Tony Triglia, Stephen W. Scally, Benjamin A. Seager, Michał Pasternak, Laura F. Dagley, Alan F. Cowman
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Plasmodium falciparum causes the most severe form of malaria in humans. The protozoan parasite develops within erythrocytes to mature schizonts, that contain more than 16 merozoites, which egress and invade fresh erythrocytes. The aspartic p
Externí odkaz:
https://doaj.org/article/26c55b01bd7d4a168188f7b3c4ab9d70
Autor:
Stephanie I Studniberg, Lisa J Ioannidis, Retno A S Utami, Leily Trianty, Yang Liao, Waruni Abeysekera, Connie S N Li‐Wai‐Suen, Halina M Pietrzak, Julie Healer, Agatha M Puspitasari, Dwi Apriyanti, Farah Coutrier, Jeanne R Poespoprodjo, Enny Kenangalem, Benediktus Andries, Pak Prayoga, Novita Sariyanti, Gordon K Smyth, Alan F Cowman, Ric N Price, Rintis Noviyanti, Wei Shi, Alexandra L Garnham, Diana S Hansen
Publikováno v:
Molecular Systems Biology, Vol 18, Iss 4, Pp 1-25 (2022)
Abstract Clinical immunity to P. falciparum malaria is non‐sterilizing, with adults often experiencing asymptomatic infection. Historically, asymptomatic malaria has been viewed as beneficial and required to help maintain clinical immunity. Emergin
Externí odkaz:
https://doaj.org/article/9505b794f7c44aa7b62ddf1faadc14f6
Autor:
Michał Pasternak, Julie M. J. Verhoef, Wilson Wong, Tony Triglia, Michael J. Mlodzianoski, Niall Geoghegan, Cindy Evelyn, Ahmad Z. Wardak, Kelly Rogers, Alan F. Cowman
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
While RhopH3 is necessary for host invasion by Plasmodium falciparum parasites, the complete RhopH complex involved in parasite nutrient uptake only incorporates into the host membrane after merozoite invasion.
Externí odkaz:
https://doaj.org/article/043058543a6744b5836c772dec1a5597
Autor:
Rebecca Webster, Silvana Sekuloski, Anand Odedra, Stephen Woolley, Helen Jennings, Fiona Amante, Katharine R. Trenholme, Julie Healer, Alan F. Cowman, Emily M. Eriksson, Priyanka Sathe, Jocelyn Penington, Adam J. Blanch, Matthew W. A. Dixon, Leann Tilley, Michael F. Duffy, Alister Craig, Janet Storm, Jo-Anne Chan, Krystal Evans, Anthony T. Papenfuss, Louis Schofield, Paul Griffin, Bridget E. Barber, Dean Andrew, Michelle J. Boyle, Fabian de Labastida Rivera, Christian Engwerda, James S. McCarthy
Publikováno v:
BMC Medicine, Vol 19, Iss 1, Pp 1-13 (2021)
Abstract Background There is a clear need for novel approaches to malaria vaccine development. We aimed to develop a genetically attenuated blood-stage vaccine and test its safety, infectivity, and immunogenicity in healthy volunteers. Our approach w
Externí odkaz:
https://doaj.org/article/74cfc9b904474091b17850c1e5910004