Zobrazeno 1 - 10
of 33
pro vyhledávání: '"P E Slagboom"'
Autor:
L. Kananen, L. Enroth, J. Raitanen, J. Jylhävä, A. Bürkle, M. Moreno-Villanueva, J. Bernhardt, O. Toussaint, B. Grubeck-Loebenstein, M. Malavolta, A. Basso, F. Piacenza, S. Collino, E. S. Gonos, E. Sikora, D. Gradinaru, E. H. J. M. Jansen, M. E. T. Dollé, M. Salmon, W. Stuetz, D. Weber, T. Grune, N. Breusing, A. Simm, M. Capri, C. Franceschi, P. E. Slagboom, D. C. S. Talbot, C. Libert, S. Koskinen, H. Bruunsgaard, ÅM. Hansen, R. Lund, M. Hurme, M. Jylhä
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Self-rated health (SRH) is one of the most frequently used indicators in health and social research. Its robust association with mortality in very different populations implies that it is a comprehensive measure of health status and may even
Externí odkaz:
https://doaj.org/article/ec3100dbf08d46afb0d1b28e54063f69
Publikováno v:
Bioinformatics, 38(15)
Bioinformatics
Bioinformatics, 38(15), 3847-3849. OXFORD UNIV PRESS
Bioinformatics
Bioinformatics, 38(15), 3847-3849. OXFORD UNIV PRESS
Motivation 1H-NMR metabolomics is rapidly becoming a standard resource in large epidemiological studies to acquire metabolic profiles in large numbers of samples in a relatively low-priced and standardized manner. Concomitantly, metabolomics-based mo
Autor:
Shin S-Y., Steffan D. Bos, Margreet Kloppenburg, Andres Metspalu, Ashok Rai, Karen E. Chapman, Tõnu Esko, J M Willkinson, Panagiotis Deloukas, Gudmar Thorleifsson, Nigel K Arden, Ingileif Jonsdottir, Andrew Carr, Kalliope Panoutsopoulou, Fernando Rivadeneira, Michelle Ricketts, F O'Neill, Sarah Metrustry, Massimo Mangino, Ollier Wer., Sarah E. Hunt, N Koller, Sally Doherty, M C Lopes, John Loughlin, Raine Eva., Andrew McCaskie, Bridget Watkins, Lorraine Southam, Gillian A. Wallis, Battley P-K., Vijay K. Yadav, U Stykarsdottir, N Aslam, Evangelos Evangelou, van Meurs Jbj., K Walker, Donald Salter, Mike R. Reed, K. Stefansson, I Carluke, E Arden, K Sherburn, Stuart Ralston, Tim D. Spector, Suzannah Bumpstead, Madhushika Ratnayake, Hannah Blackburn, K S Elliott, H Jonnson, Guangju Zhai, Michael Doherty, M. Wheeler, Thorvaldur Ingvarsson, Ingrid Meulenbelt, J Joseph, Fraser Birrell, D Swift, A.G. Uitterlinden, K Dixon, Ioannidis Jpa., Hanneke J. M. Kerkhof, Aaron G. Day-Williams, E Paling, Simon C. Potter, Ana M. Valdes, P E Slagboom, Richard Keen, Sheryl Mitchell, C Beazley, Eleftheria Zeggini, A Hoffman, Vesna Boraska, Jeanine J. Houwing-Duistermaat, Allan Gordon, N W Rayner
Publikováno v:
Lancet
Zeggini, E, Panoutsopoulou, K, Southam, L, Rayner, N W, Day-Williams, A G, Lopes, M C, Boraska, V, Esko, T, Evangelou, E, Hofman, A, Houwing-Duistermaat, J J, Ingvarsson, T, Jonsdottir, I, Jonsson, H, Kerkhof, H J M, Kloppenburg, M, Bos, S D, Mangino, M, Metrustry, S, Slagboom, P E, Thorleifsson, G, Raine, E V A, Ratnayake, M, Ricketts, M, Beazley, C, Blackburn, H, Bumpstead, S, Elliott, K S, Hunt, S E, Potter, S C, Shin, S-Y, Yadav, V K, Zhai, G, Sherburn, K, Dixon, K, Arden, E, Aslam, N, Battley, P-K, Carluke, I, Doherty, S, Gordon, A, Joseph, J, Keen, R, Koller, N C, Mitchell, S, O'Neill, F, Paling, E, Reed, M R & Salter, D & Ralston, S H 2012, ' Identification of new susceptibility loci for osteoarthritis (arcOGEN) : a genome-wide association study ', The Lancet, vol. 380, no. 9844, pp. 815-823 . https://doi.org/10.1016/S0140-6736(12)60681-3
The Lancet; Vol 380
Zeggini, E, Panoutsopoulou, K, Southam, L, Rayner, N W, Day-Williams, A G, Lopes, M C, Boraska, V, Esko, T, Evangelou, E, Hofman, A, Houwing-Duistermaat, J J, Ingvarsson, T, Jonsdottir, I, Jonsson, H, Kerkhof, H J M, Kloppenburg, M, Bos, S D, Mangino, M, Metrustry, S, Slagboom, P E, Thorleifsson, G, Raine, E V A, Ratnayake, M, Ricketts, M, Beazley, C, Blackburn, H, Bumpstead, S, Elliott, K S, Hunt, S E, Potter, S C, Shin, S-Y, Yadav, V K, Zhai, G, Sherburn, K, Dixon, K, Arden, E, Aslam, N, Battley, P-K, Carluke, I, Doherty, S, Gordon, A, Joseph, J, Keen, R, Koller, N C, Mitchell, S, O'Neill, F, Paling, E, Reed, M R & Salter, D & Ralston, S H 2012, ' Identification of new susceptibility loci for osteoarthritis (arcOGEN) : a genome-wide association study ', The Lancet, vol. 380, no. 9844, pp. 815-823 . https://doi.org/10.1016/S0140-6736(12)60681-3
The Lancet; Vol 380
BACKGROUND: Osteoarthritis is the most common form of arthritis worldwide and is a major cause of pain and disability in elderly people. The health economic burden of osteoarthritis is increasing commensurate with obesity prevalence and longevity. Os
Publikováno v:
Twin Research (2000). 3:134-141
This study reports on zygosity determination in twins of childhood age. Parents responded to questionnaire items dealing with twin similarity in physical characteristics and frequency of mistaking one twin for another by parents, relatives and strang
Autor:
D. E. Grobbee, A. Hofman, Peter J. Koudstaal, Cornelis Kluft, P. E. Slagboom, Monique M.B. Breteler, Michiel L. Bots, F van Kooten, Piet Meijer, Frits Haverkate
Publikováno v:
Haemostasis, 28, 209-215. Karger
We performed a cross-sectional case-control study among 295 subjects with dementia and 406 control subjects drawn from participants of the Rotterdam Study, a population-based cohort study among subjects aged 55 years or over, and from participants of
Autor:
R, Noordam, D A, Gunn, C C, Tomlin, A B, Maier, T, Griffiths, S D, Catt, S, Ogden, P E, Slagboom, R G J, Westendorp, C E M, Griffiths, D, van Heemst, A J M, de Craen
Publikováno v:
The British journal of dermatology. 168(3)
Insulin-like growth factor (IGF)-1 is a growth factor that can influence fibroblast functioning, with effects including the inhibition of collagenases and the induction of collagen expression.To assess whether serum IGF-1, IGF-binding protein (IGFBP)
Publikováno v:
Annals of human genetics. 74(6)
When conducting genetic studies for complex traits, large samples are commonly required to detect new genetic factors. A possible strategy to decrease the sample size is to reduce heterogeneity using available information. In this paper we propose a
Autor:
S. Das, Michael N. Weedon, Torben Hansen, J. V. van Vliet-Ostaptchouk, J. M. Dekker, Giel Nijpels, Alex S. F. Doney, André G. Uitterlinden, Johannes A Maassen, M. J. Groenewoud, E. C. van Hove, Erwin Reiling, T.W. van Haeften, Richa Saxena, Leif Groop, Marten H. Hofker, Johannes A. Romijn, P. E. Slagboom, Andrew D. Morris, Oluf Pedersen, Jan W. A. Smit, P. A. Arp, Colin N. A. Palmer, Mark I. McCarthy, Leen M 't Hart, Bahram Jafar-Mohammadi, Timothy M. Frayling, Candace Guiducci, Andrew T. Hattersley, David Altshuler, E. van 't Riet
Publikováno v:
Diabetologia, 53(1), 103-10
Diabetologia, 53(1), 103-110
Diabetologia, 53(1), 103-110. Springer Verlag
Diabetologia; Vol 53
Reiling, E, Jafar-Mohammadi, B, van 't Riet, E, Weedon, M N, van Vliet-Ostaptchouk, J V, Hansen, T, Saxena, R, van Haeften, T W, Arp, P A, Das, S, Nijpels, G, Groenewoud, M J, van Hove, E C, Uitterlinden, A G, Smit, J W A, Morris, A D, Doney, A S F, Palmer, C N A, Guiducci, C, Hattersley, A T, Frayling, T M, Pedersen, O, Slagboom, P E, Altshuler, D M, Groop, L, Romijn, J A, Maassen, J A, Hofker, M H, Dekker, J M, McCarthy, M I & Hart, L M 2010, ' Genetic association analysis of LARS2 with type 2 diabetes ', Diabetologia, vol. 53, no. 1, pp. 103-110 . https://doi.org/10.1007/s00125-009-1557-7
Diabetologia, 53(1), 103-110. SPRINGER
Diabetologia
Diabetologia, 53(1), 103-110. Springer-Verlag
Reiling, E, Jafar-Mohammadi, B, van 't Riet, E, Weedon, M N, van Vliet-Ostaptchouk, J V, Hansen, T, Saxena, R, van Haeften, T W, Das, S, Arp, P A, Nijpels, G, Groenewoud, M J, van Hove, E C, Uitterlinden, A G, Smit, J W A, Morris, A D, Doney, A S F, Palmer, C N A, Guiducci, C, Hattersley, A T, Frayling, T M, Pedersen, O, Slagboom, P E, Altshuler, D M, Groop, L, Romijn, J A, Maassen, J A, Hofker, M H, Dekker, J M, McCarthy, M I & 't Hart, L M 2010, ' Genetic association analysis of LARS2 with type 2 diabetes ', Diabetologia, vol. 53, no. 1, pp. 103-10 . https://doi.org/10.1007/s00125-009-1557-7
Diabetologia, 53(1), 103-110
Diabetologia, 53(1), 103-110. Springer Verlag
Diabetologia; Vol 53
Reiling, E, Jafar-Mohammadi, B, van 't Riet, E, Weedon, M N, van Vliet-Ostaptchouk, J V, Hansen, T, Saxena, R, van Haeften, T W, Arp, P A, Das, S, Nijpels, G, Groenewoud, M J, van Hove, E C, Uitterlinden, A G, Smit, J W A, Morris, A D, Doney, A S F, Palmer, C N A, Guiducci, C, Hattersley, A T, Frayling, T M, Pedersen, O, Slagboom, P E, Altshuler, D M, Groop, L, Romijn, J A, Maassen, J A, Hofker, M H, Dekker, J M, McCarthy, M I & Hart, L M 2010, ' Genetic association analysis of LARS2 with type 2 diabetes ', Diabetologia, vol. 53, no. 1, pp. 103-110 . https://doi.org/10.1007/s00125-009-1557-7
Diabetologia, 53(1), 103-110. SPRINGER
Diabetologia
Diabetologia, 53(1), 103-110. Springer-Verlag
Reiling, E, Jafar-Mohammadi, B, van 't Riet, E, Weedon, M N, van Vliet-Ostaptchouk, J V, Hansen, T, Saxena, R, van Haeften, T W, Das, S, Arp, P A, Nijpels, G, Groenewoud, M J, van Hove, E C, Uitterlinden, A G, Smit, J W A, Morris, A D, Doney, A S F, Palmer, C N A, Guiducci, C, Hattersley, A T, Frayling, T M, Pedersen, O, Slagboom, P E, Altshuler, D M, Groop, L, Romijn, J A, Maassen, J A, Hofker, M H, Dekker, J M, McCarthy, M I & 't Hart, L M 2010, ' Genetic association analysis of LARS2 with type 2 diabetes ', Diabetologia, vol. 53, no. 1, pp. 103-10 . https://doi.org/10.1007/s00125-009-1557-7
Aims/hypothesis LARS2 has been previously identified as a potential type 2 diabetes susceptibility gene through the low-frequency H324Q (rs71645922) variant (minor allele frequency [MAF] 3.0%). However, this association did not achieve genome-wide le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55b833de640cd2fd72a5853ad70f6fc0
https://hdl.handle.net/1887/119043
https://hdl.handle.net/1887/119043
Autor:
Meike Bartels, Dorret I. Boomsma, P. E. Slagboom, Conor V. Dolan, Ingrid Meulenbelt, E. F. van Furth, Irene Rebollo-Mesa, C.E.M. van Beijsterveldt, M. C. T. Slof-Op 't Landt
Publikováno v:
ResearcherID
Assessment, 16(4), 415-423. SAGE Publications Inc.
Slof-Op 't Landt, M C T, Furth, E F V, Rebollo-Mesa, I, Bartels, M, van Beijsterveldt, C E M, Slagboom, P E, Boomsma, D I, Meulenbelt, I & Dolan, C V 2009, ' Sex Differences in Sum Scores May Be Hard to Interpret: The Importance of Measurement Invariance ', Assessment, vol. 16, no. 4, pp. 415-423 . https://doi.org/10.1177/1073191109344827
Assessment, 16(4), 415-423. SAGE Publications Inc.
Slof-Op 't Landt, M C T, Furth, E F V, Rebollo-Mesa, I, Bartels, M, van Beijsterveldt, C E M, Slagboom, P E, Boomsma, D I, Meulenbelt, I & Dolan, C V 2009, ' Sex Differences in Sum Scores May Be Hard to Interpret: The Importance of Measurement Invariance ', Assessment, vol. 16, no. 4, pp. 415-423 . https://doi.org/10.1177/1073191109344827
In most assessment instruments, distinct items are designed to measure a trait, and the sum score of these items serves as an approximation of an individual's trait score. In interpreting group differences with respect to sum scores, the instrument s
Publikováno v:
Aging Clinical and Experimental Research. 3:141-146
Methylation patterns of MHC (major histocompatibility complex) class I and vKi-ras (viral Kirsten-ras) homologous sequences in normal and adenomatous rat pituitary glands were studied as a function of age by Southern hybridization analysis using the